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Details:

Under the agreement, PharmaEssentia will obtain the global exclusive rights to research, develop, manufacture and commercialize a myeloid immune checkpoint antibody candidate.


Lead Product(s): Myeloid Immune Checkpoint Antibody

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Recipient: WuXi Biologics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement October 03, 2023

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Under the agreement, Pint-Pharma will be obtaining and maintaining all marketing authorizations and commercializing BESREMi (ropeginterferon alfa-2b-njft), the first approved mono-pegylated proline interferon for polycythemia vera, a rare blood cancer, in Latin America.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: Besremi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Pint Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement June 02, 2023

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BESREMi (ropeginterferon alfa-2b-njft) binds to IFNAR initiates a downstream signaling cascade through the activation of kinases, in particular JAK1 and TYK2 and activator of transcription (STAT) proteins. It is indicated for the polycythemia vera.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: BESREMi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 23, 2023

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The collaboration will leverage Nona’s proprietary Harbour Mice® fully human antibody transgenic mice platform for the discovery of fully human monoclonal antibodies in classical two light and two heavy chain (H2L2) format, and heavy chain only (HCAb) formats.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Recipient: Nona Biosciences

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration May 12, 2023

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BESREMi (ropeginterferon alfa-2b-njft) binds to IFNAR initiates a downstream signaling cascade through the activation of kinases, in particular JAK1 and TYK2 and activator of transcription (STAT) proteins. It is being investigated for polycythemia vera.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: BESREMi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 03, 2023

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The net proceeds from the offering will be used to to support growth plans and pipeline development, including Besremi (ropeginterferon alfa-2b-njft), an innovative monopegylated, long-acting interferon for the treatment of polycythemia vera (PV) in adults.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: Besremi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Undisclosed

Deal Size: $462.7 million Upfront Cash: Undisclosed

Deal Type: Public Offering April 21, 2023

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Details:

BESREMi (ropeginterferon alfa-2b-njft) binds to IFNAR initiates a downstream signaling cascade through the activation of kinases, in particular JAK1 and TYK2 and activator of transcription (STAT) proteins.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: BESREMi

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 23, 2023

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Details:

BESREMi (ropeginterferon alfa-2b-njft) binds to IFNAR initiates a downstream signaling cascade through the activation of kinases, in particular JAK1 and TYK2 and activator of transcription (STAT) proteins.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: BESREMi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 02, 2023

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Details:

BESREMi (ropeginterferon alfa-2b-njft), is an innovative monopegylated, long-acting interferon. With its unique pegylation technology, BESREMi has a long duration of activity in the body and is aimed to be administered once every two weeks.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: Besremi

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 12, 2022

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Details:

P1101 (ropeginterferon alfa-2b-njft) is unique monopegylated, long-acting interferon to treat adults with polycythemia vera. Given well-established safety and efficacy profile demonstrated in prior studies, treatment may represent useful alternative to approved options for ET.


Lead Product(s): Ropeginterferon-Alfa-2b

Therapeutic Area: Oncology Product Name: P1101

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 08, 2022

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