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FDA provides complete approval to enroll patients in its pivotal clinical trial to evaluate "MC-1" (a naturally occurring metabolite of pyridoxine) for treatment of a rare pediatric disease called pyridox(am)ine 5′-phosphate oxidase deficiency.


Lead Product(s): Pyridoxal Phosphate

Therapeutic Area: Rare Diseases and Disorders Product Name: MC-1

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 23, 2023

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The Agreement grants an exclusive right to Medicure to market and sell the Product in the United States of America, Canada and the European Union.


Lead Product(s): Undisclosed

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Undisclosed

Highest Development Status: UndisclosedProduct Type: Large molecule

Recipient: Reliance Life Sciences Private Limited

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement October 05, 2020

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Notably, a non-randomized, case-controlled, investigator sponsored proof of concept study evaluating AGGRASTAT® in combination with standard of care in patients with severe COVID-19 and hypercoagulability found that enhanced platelet inhibition improves hypoxemia.


Lead Product(s): Tirofiban,Clopidogrel,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Aggrastat

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 24, 2020

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The FABOLUS-FASTER trial was designed to assess different regimens of intravenous platelet inhibitors, notably AGGRASTAT® (tirofiban hydrochloride) injection (an IV GP IIb/IIIa inhibitor) and cangrelor (an IV P2Y12 inhibitor) in the early phase of primary PCI.


Lead Product(s): Tirofiban,Prasugrel

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Aggrastat

Highest Development Status: Phase IVProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 15, 2020

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