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Helsinn Advanced Synthesis
Switzerland Flag
Country
Country
Switzerland
Address
Address
Via Industria 246710 Biasca – Switzerland
Telephone
Telephone
+41 (0) 91 873.94.00

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Akynzeo is a combination of netupitant, a selective antagonist of human substance P/neurokinin 1 (NK-1) receptors and palonosetron, a 5-HT3 receptor antagonist with a strong binding affinity for this receptor. It is indicated for nausea due to cancer chemotherapy.


Lead Product(s): Netupitant,Palonosetron

Therapeutic Area: Gastroenterology Product Name: Akynzeo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 03, 2023

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Akynzeo (netupitant) is a 5-HT3 and NK1 receptor antagonist fixed combination approved in Europe in adults for the prevention of acute and delayed nausea and vomiting associated with cisplatin-based highly emetogenic chemotherapy and moderately emetogenic chemotherapy.


Lead Product(s): Netupitant,Palonosetron

Therapeutic Area: Gastroenterology Product Name: Akynzeo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Immedica Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement January 24, 2023

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Adlumiz (anamorelin) is a selective, novel, orally active ghrelin receptor agonist. Upon binding to its receptor, ghrelin stimulates multiple pathways in the positive regulation of body weight, muscle mass, appetite and metabolism.


Lead Product(s): Anamorelin

Therapeutic Area: Nutrition and Weight Loss Product Name: Adlumiz

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Oberland Capital Management

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Financing January 10, 2023

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AKYNZEO (Netupitant) is the first and only 5-HT3 and NK1 receptor antagonist fixed combination approved in adults for the prevention of acute and delayed nausea and vomiting associated with cisplatin based highly emetogenic chemotherapy and moderately emetogenic chemotherapy.


Lead Product(s): Netupitant,Palonosetron

Therapeutic Area: Gastroenterology Product Name: Akynzeo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 04, 2023

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Akynzeo is the first and only 5-HT3 and NK1 receptor antagonist fixed combination approved in adults for the prevention of acute and delayed nausea and vomiting associated with highly and moderately emetogenic chemotherapy.


Lead Product(s): Netupitant,Palonosetron

Therapeutic Area: Gastroenterology Product Name: Akynzeo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 29, 2022

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VALCHLOR® (mechlorethamine) gel 0.016% is indicated for the topical treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL) in patients who have received prior skin-directed therapy.


Lead Product(s): Mechlorethamine

Therapeutic Area: Oncology Product Name: Ledaga

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 18, 2022

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LEDAGA® (chlormethine) gel is an alkylating drug indicated for the topical treatment of MF-CTCL in adult patients. LEDAGA® is a gel which is applied topically once a day.


Lead Product(s): Mechlorethamine

Therapeutic Area: Oncology Product Name: Ledaga

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 21, 2022

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Under the agreement, the registeration, distribution, promotion, market and sell LEDAGA® (chlormethine gel) in Australia, Asia and the Middle East* as a topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma (“MF-CTCL”) in adults.


Lead Product(s): Mechlorethamine

Therapeutic Area: Oncology Product Name: Ledaga

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Juniper Biologics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement September 01, 2022

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Vepafestinib (also known as TAS0953/HM06 is an investigational, potent, orally administered, and highly selective RET inhibitor1,4. In preclinical studies, vepafestinib has shown activity against RET solvent front (G810) and gatekeeper (V804) mutations.


Lead Product(s): Vepafestinib

Therapeutic Area: Oncology Product Name: TAS0953

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 08, 2022

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Vepafestinib (TAS0953/HM06) is an investigational, potent, orally administered, highly selective RET inhibitor, is pharmacologically distinct, exhibits a distinct binding mode to RET, and has shown evidence of enhanced brain penetrability characteristics in preclinical model.


Lead Product(s): Vepafestinib

Therapeutic Area: Oncology Product Name: TAS0953

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Taiho Pharmaceutical

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 02, 2022

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