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Under the agreement, Amneal will have exclusive rights to market and distribute ONGENTYS (opicapone), a highly-selective COMT inhibitor, which is approved by USFDA as an add-on treatment to carbidopa/levodopa in patients with Parkinson’s disease experiencing Off episodes.


Lead Product(s): Opicapone

Therapeutic Area: Neurology Product Name: Ongentys

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Amneal Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement December 07, 2023

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BIA 28-6156 is an allosteric activator of the enzyme beta-glucocerebrosidase (GCase) for the treatment of patients with Parkinson's disease (PD) who have a mutation in the glucocerebrosidase 1 (GBA1) gene (GBA-PD).


Lead Product(s): BIA 28-6156

Therapeutic Area: Neurology Product Name: BIA 28-6156

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 25, 2023

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Under the terms of the agreement, BIAL will be responsible for regulatory approvals and submissions, including interactions with the European Medicines Agency (EMA) for APL-130277, which is currently in Phase 3 clinical development in Europe.


Lead Product(s): Apomorphine Hydrochloride

Therapeutic Area: Neurology Product Name: Kynmobi

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Sunovion Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement September 02, 2021

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BIAL takes the lead for the marketing and distribution of Zebinix® (eslicarbazepine acetate) in Europe. Eslicarbazepine acetate is a once-daily anti-epileptic used to treat epilepsy patients with focal seizures (partial-onset seizures).


Lead Product(s): Eslicarbazepine Acetate

Therapeutic Area: Neurology Product Name: Zebinix

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Eisai

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Termination February 17, 2021

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The new agreement provides both companies with a long-term partnership that will ensure continued supply for patients across the globe. Opicapone (Ongentys) is approved in Europe, USA, South Korea, Taiwan, Australia and Japan.


Lead Product(s): Opicapone

Therapeutic Area: Neurology Product Name: Ongentys

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Recipharm AB

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement October 01, 2020

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