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Tevimbra (tislelizumab), now FDA approved, is a humanized IgG4 anti-PD-1 monoclonal antibody specifically designed to minimize binding to Fc-gamma receptors on macrophages, helping to aid the body’s immune cells to detect and fight with locally advanced, or metastatic ESCC.
Lead Product(s): Tislelizumab
Therapeutic Area: Oncology Product Name: Tevimbra
Highest Development Status: ApprovedProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 14, 2024
Details:
BeiGene has granted accelerated approval to Brukinsa (zanubrutinib), BTK Inhibitor for the treatment of adult patients with relapsed or refractory follicular lymphoma, in combination with the anti-CD20 monoclonal antibody obinutuzumab.
Lead Product(s): Zanubrutinib,Obinutuzumab
Therapeutic Area: Oncology Product Name: Brukinsa
Highest Development Status: ApprovedProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 07, 2024
Details:
Brukinsa (zanubrutinib) is a small molecule inhibitor of BTK designed to deliver complete and sustained inhibition of the BTK protein. It is being evaluated for the treatment of relapsed/refractory chronic lymphocytic leukemia.
Lead Product(s): Zanubrutinib
Therapeutic Area: Oncology Product Name: Brukinsa
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 29, 2024
Details:
Tevimbra (tislelizumab) is a uniquely designed humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is being evaluated for the treatment of first-line gastric or gastroesophageal junction cancers.
Lead Product(s): Tislelizumab,Carboplatin,Fluoropyrimidine
Therapeutic Area: Oncology Product Name: Tevimbra
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 27, 2024
Details:
Tevimbra (tislelizumab) is a uniquely designed humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is being evaluated for the treatment of advanced squamous NSCLC.
Lead Product(s): Tislelizumab,Paclitaxel,Carboplatin
Therapeutic Area: Oncology Product Name: Tevimbra
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 26, 2024
Details:
Under the agreement, BeiGene will acquire an exclusive global license to an Investigational New Drug application-ready, ETX-197, an oral cyclin-dependent kinase 2 (CDK2) inhibitor.
Lead Product(s): ETX-197
Therapeutic Area: Oncology Product Name: ETX-197
Highest Development Status: IND EnablingProduct Type: Small molecule
Recipient: Ensem Therapeutics
Deal Size: $1,330.0 million Upfront Cash: Undisclosed
Deal Type: Licensing Agreement November 21, 2023
Details:
Brukinsa (zanubrutinib) is a small molecule inhibitor of BTK. It is now approved by European Commision for the treatment of relapsed or refractory follicular lymphoma.
Lead Product(s): Zanubrutinib,Obinutuzumab
Therapeutic Area: Oncology Product Name: Brukinsa
Highest Development Status: ApprovedProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 17, 2023
Details:
Brukinsa (zanubrutinib) is a small-molecule inhibitor of BTK that is receives positive recommendation from NICE in U.K. for adult patients with chronic lymphocytic leukemia.
Lead Product(s): Zanubrutinib
Therapeutic Area: Oncology Product Name: Brukinsa
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 20, 2023
Details:
Brukinsa (zanubrutinib), a bruton’s tyrosine kinase inhibitor (BTKi), is being developed in combination with obinutuzumab for the treatment of adult patients with R/R follicular lymphoma (FL). If approved, brukinsa will be the first and only BTKi approved for FL.
Lead Product(s): Zanubrutinib,Obinutuzumab
Therapeutic Area: Oncology Product Name: Brukinsa
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 13, 2023
Details:
Tevimbra (tislelizumab) is a humanized IgG4 anti-PD-1 monoclonal antibody specifically designed to minimize binding to Fc-gamma (Fcγ) receptors on macrophages, helping to aid the body’s immune cells to detect and fight with locally advanced, or metastatic ESCC.
Lead Product(s): Tislelizumab
Therapeutic Area: Oncology Product Name: Tevimbra
Highest Development Status: ApprovedProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 19, 2023
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