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Vyvgart (efgartigimod alfa) is a USFDA approved neonatal Fc receptor blocker, which is being evaluated for the treatment of adult patients with primary sjogren’s disease.


Lead Product(s): Efgartigimod Alfa

Therapeutic Area: Immunology Product Name: Vyvgart

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 27, 2024

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VYVGART (efgartigimod alfa) is a USFDA approved neonatal Fc receptor blocker, which is approved for the treatment of adult patients with primary immune thrombocytopenia.


Lead Product(s): Efgartigimod Alfa

Therapeutic Area: Immunology Product Name: Vyvgart

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 26, 2024

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Vyvgart Hytrulo is a subcutaneous combination of efgartigimod alfa, a human IgG1 antibody fragment, & recombinant human hyaluronidase PH20 (rHuPH20). It is being evaluated for the treatment of chronic inflammatory demyelinating polyneuropathy.


Lead Product(s): Efgartigimod,rHuPH20

Therapeutic Area: Neurology Product Name: Vyvgart Hytrulo

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 20, 2024

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Vyvdura (efgartigimod alfa and hyaluronidase-qvfc) is a human IgG1 antibody fragment marketed for intravenous use. It is approved for the treatment of Generalized myasthenia gravis (gMG).


Lead Product(s): Efgartigimod Alfa,Hyaluronidase-qvfc

Therapeutic Area: Immunology Product Name: Vyvdura

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 18, 2024

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Efgartigimod SC (efgartigimod alfa and hyaluronidase-qvfc) subcutaneous injection is being evaluated in phase 3 clinical trials for the treatment of pemphigus vulgaris (PV) and pemphigus foliaceus (PF).


Lead Product(s): Efgartigimod Alfa,Hyaluronidase

Therapeutic Area: Immunology Product Name: Efgartigimod SC

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 19, 2023

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VYVGART Hytrulo, a subcutaneous combination of efgartigimod alfa, a human IgG1 antibody fragment, and recombinant human hyaluronidase PH20, Halozyme’s ENHANZE® drug delivery technolog, is being developed for in adults with primary immune thrombocytopenia (ITP).


Lead Product(s): Efgartigimod Alfa,Hyaluronidase

Therapeutic Area: Immunology Product Name: Vyvgart Hytrulo

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 28, 2023

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Vyvgart (efgartigimod alfa-fcab) is a human IgG1 antibody fragment formulated with recombinant human hyaluronidase PH20 (rHuPH20). It is approved for the treatment of for generalized myasthenia gravis.


Lead Product(s): Efgartigimod

Therapeutic Area: Immunology Product Name: Vyvgart

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 16, 2023

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LEO 138559 (temtokibart) is an investigational monoclonal antibody that targets the IL-22RA1 receptor subunit, currently in Phase 2 development for the potential treatment of moderate-to-severe atopic dermatitis.


Lead Product(s): Temtokibart

Therapeutic Area: Dermatology Product Name: LEO 138559

Highest Development Status: Phase IIProduct Type: Large molecule

Recipient: Leo Pharma

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 11, 2023

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Vyvgart (efgartigimod alfa and hyaluronidase-qvfc) injection is formulated with ENHANZE for subcutaneous (SC) use for the treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive.


Lead Product(s): Efgartigimod

Therapeutic Area: Immunology Product Name: Vyvgart

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 15, 2023

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The net proceeds will be used to accelerate company's commercial investment to propel Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) and Vyvgart (efgartigimod alfa fcab) as a leading therapy globally.


Lead Product(s): Efgartigimod Alfa,Hyaluronidase-qvfc

Therapeutic Area: Immunology Product Name: Vyvgart Hytrulo

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: J.P. Morgan

Deal Size: $1,270.0 million Upfront Cash: Undisclosed

Deal Type: Public Offering July 24, 2023

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