Find Zorifertinib manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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FINISHED DOSAGE FORMULATIONS

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: Azd3759, 1626387-80-1, Zorifertinib, Azd-3759, Azd 3759, Chembl3623290
Molecular Formula
C22H23ClFN5O3
Molecular Weight
459.9  g/mol
InChI Key
MXDSJQHFFDGFDK-CYBMUJFWSA-N
FDA UNII
67SX9H68W2

Zorifertinib
Zorifertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, zorifertinib binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
1 2D Structure

Zorifertinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate
2.1.2 InChI
InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
2.1.3 InChI Key
MXDSJQHFFDGFDK-CYBMUJFWSA-N
2.1.4 Canonical SMILES
CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
2.1.5 Isomeric SMILES
C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
2.2 Other Identifiers
2.2.1 UNII
67SX9H68W2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

2. Azd3759

2.3.2 Depositor-Supplied Synonyms

1. Azd3759

2. 1626387-80-1

3. Zorifertinib

4. Azd-3759

5. Azd 3759

6. Chembl3623290

7. 67sx9h68w2

8. 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl (2r)-2,4-dimethylpiperazine-1-carboxylate

9. (2r)-2,4-dimethyl-1-piperazinecarboxylic Acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl Ester

10. [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2r)-2,4-dimethylpiperazine-1-carboxylate

11. 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2r)-2,4-dimethylpiperazine-1-carboxylate

12. Zorifertinib [inn]

13. Unii-67sx9h68w2

14. Zorifertinib [who-dd]

15. Schembl16010006

16. Gtpl10456

17. Ex-a720

18. Amy10302

19. Bdbm50123453

20. Mfcd29058564

21. Nsc788121

22. Nsc800978

23. S7971

24. Akos027327321

25. Zinc221149242

26. Ccg-269329

27. Cs-5029

28. Db14795

29. Nsc-788121

30. Nsc-800978

31. Compound 1m [pmid: 26313252]

32. Ncgc00483922-01

33. Ncgc00483922-02

34. Ac-29957

35. As-74755

36. Hy-18750

37. A882818

38. (2r)-2,4-dimethyl-1-piperazinecarboxylic Acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl Ester

39. (2r)-2,4-dimethylpiperazine-1-carboxylic Acid (4-(2-fluoro-3-chloroanilino)-7-methoxyquinazoline-6-yl) Ester

40. (r)-4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

41. 1-piperazinecarboxylic Acid, 2,4-dimethyl-, 4-((3-chloro-2-fluorophenyl)amino)-7-methoxy-6-quinazolinyl Ester, (2r)-

2.4 Create Date
2014-09-29
3 Chemical and Physical Properties
Molecular Weight 459.9 g/mol
Molecular Formula C22H23ClFN5O3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass459.1473455 g/mol
Monoisotopic Mass459.1473455 g/mol
Topological Polar Surface Area79.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1626387-80-1 / Zorifertinib API manufacturers, exporters & distributors?

Zorifertinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Zorifertinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zorifertinib manufacturer or Zorifertinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zorifertinib manufacturer or Zorifertinib supplier.

PharmaCompass also assists you with knowing the Zorifertinib API Price utilized in the formulation of products. Zorifertinib API Price is not always fixed or binding as the Zorifertinib Price is obtained through a variety of data sources. The Zorifertinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Zorifertinib

Synonyms

Azd3759, 1626387-80-1, Azd-3759, Azd 3759, Chembl3623290, 67sx9h68w2

Cas Number

1626387-80-1

Unique Ingredient Identifier (UNII)

67SX9H68W2

About Zorifertinib

Zorifertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, zorifertinib binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Zorifertinib Manufacturers

A Zorifertinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zorifertinib, including repackagers and relabelers. The FDA regulates Zorifertinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zorifertinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zorifertinib Suppliers

A Zorifertinib supplier is an individual or a company that provides Zorifertinib active pharmaceutical ingredient (API) or Zorifertinib finished formulations upon request. The Zorifertinib suppliers may include Zorifertinib API manufacturers, exporters, distributors and traders.

Zorifertinib GMP

Zorifertinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zorifertinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zorifertinib GMP manufacturer or Zorifertinib GMP API supplier for your needs.

Zorifertinib CoA

A Zorifertinib CoA (Certificate of Analysis) is a formal document that attests to Zorifertinib's compliance with Zorifertinib specifications and serves as a tool for batch-level quality control.

Zorifertinib CoA mostly includes findings from lab analyses of a specific batch. For each Zorifertinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zorifertinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Zorifertinib EP), Zorifertinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zorifertinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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