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    Chemistry

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    Also known as: Vitamin a acetate, Retinol acetate, 127-47-9, Retinol, acetate, All-trans-retinyl acetate, Crystalets
    Molecular Formula
    C22H32O2
    Molecular Weight
    328.5  g/mol
    InChI Key
    QGNJRVVDBSJHIZ-QHLGVNSISA-N
    FDA UNII
    3LE3D9D6OY
    Vitamin A Acetate
    Retinyl Acetate is a naturally-occurring fatty acid ester form of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Retinyl acetate binds to and activates retinoid receptors, inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation in some cancer cell types and exhibits immunomodulatory properties. (NCI04)
    1 2D Structure

    Vitamin A Acetate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
    2.1.2 InChI
    InChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
    2.1.3 InChI Key
    QGNJRVVDBSJHIZ-QHLGVNSISA-N
    2.1.4 Canonical SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCOC(=O)C)C)C
    2.1.5 Isomeric SMILES
    CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/COC(=O)C)/C)/C
    2.2 Other Identifiers
    2.2.1 UNII
    3LE3D9D6OY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 9-cis-retinyl Acetate

    2. All-trans-retinyl Acetate

    3. Dagravit A Forte

    4. Dif Vitamin A Masivo

    5. Qlt091001

    6. Retinit

    7. Retinol Acetate

    8. Retinol Acetate, (9,13-cis)-isomer

    9. Vitamin A Acetate

    10. Vitamin A Dispersa

    11. Vitamin-a-saar

    2.3.2 Depositor-Supplied Synonyms

    1. Vitamin A Acetate

    2. Retinol Acetate

    3. 127-47-9

    4. Retinol, Acetate

    5. All-trans-retinyl Acetate

    6. Crystalets

    7. Vitamin A1 Acetate

    8. All-trans-retinol Acetate

    9. Vitamin A Alcohol Acetate

    10. Davitan A 650

    11. Vitamin A Ester

    12. All-trans-vitamin A Acetate

    13. Retinol, Acetate, All-trans-

    14. O~15~-acetylretinol

    15. Nsc 122045

    16. Trans-retinyl Acetate

    17. [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] Acetate

    18. Ro 1-5275

    19. Retinol Acetate [jan]

    20. Trans-vitamin A Acetate

    21. Myvak (van)

    22. Myvax (van)

    23. 3le3d9d6oy

    24. All-trans-retinylacetate

    25. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl Acetate

    26. Chebi:32095

    27. Vitamin A Acetate (van)

    28. Acetic Acid, Retinyl Ester

    29. Nsc-122045

    30. Nsc-122760

    31. Ncgc00090756-09

    32. Retinol Acetate/all-trans-retinyl Acetate

    33. Dsstox_cid_1240

    34. Dsstox_rid_76032

    35. Dsstox_gsid_21240

    36. Vitaminaacetate

    37. Vitamin A Acetate (tritiated)

    38. Vitamin A, Acetate

    39. Retinol, Acetate, Labeled With Tritium

    40. O(15)-acetylretinol

    41. 9-cis Retinol Acetate

    42. Retinyl Acetate, All-trans-

    43. Cas-127-47-9

    44. Ccris 1907

    45. Trans-retinol Acetate

    46. Sr-05000001431

    47. Einecs 204-844-2

    48. Unii-3le3d9d6oy

    49. Brn 1915439

    50. Retinyl-acetate

    51. Wln: L6utj A1 B1u1y1 & U2u1y1 & U2ov1 C1 C1

    52. Vitamin A Acetat

    53. 34356-31-5

    54. Acetic Acid Retinyl

    55. Mfcd00019413

    56. Oristar Ra

    57. (13z)-retinol Acetate

    58. Spectrum5_001195

    59. Spectrum5_002001

    60. Retinol Acetate (jp17)

    61. Retinyl (retinol) Acetate

    62. Ec 204-844-2

    63. Retinol, O~15~-acetyl-

    64. Bspbio_002833

    65. Spectrum1503051

    66. Retinyl Acetate [inci]

    67. C22h32o2 (retinol Acetate)

    68. Chembl486193

    69. Vitamin A Acetate [mi]

    70. Dtxsid6021240

    71. Chebi:94695

    72. Hms501k04

    73. Retinol Acetate [who-dd]

    74. Retinyl Acetate [usp-rs]

    75. Vitamin A Acetate [vandf]

    76. Hms1922a19

    77. Hms2089g20

    78. Pharmakon1600-01503051

    79. Amy13865

    80. Hy-n0679

    81. Zinc3874857

    82. Retinyl Acetate, Analytical Standard

    83. Tox21_113549

    84. Tox21_201423

    85. Tox21_302737

    86. Bdbm50442911

    87. Ccg-39564

    88. Lmpr01090012

    89. Nsc122045

    90. Nsc122760

    91. Nsc758220

    92. S4083

    93. Akos015914999

    94. Tox21_113549_1

    95. Cs-8187

    96. Nsc-758220

    97. Idi1_000522

    98. Ncgc00090756-01

    99. Ncgc00090756-02

    100. Ncgc00090756-03

    101. Ncgc00090756-05

    102. Ncgc00090756-06

    103. Ncgc00090756-07

    104. Ncgc00090756-08

    105. Ncgc00090756-10

    106. Ncgc00090756-11

    107. Ncgc00090756-12

    108. Ncgc00256509-01

    109. Ncgc00258974-01

    110. Vitamin A (as Acetate) [vandf]

    111. 64536-04-5

    112. Ac-19999

    113. All-(e)-retinol Acetate [who-ip]

    114. Sbi-0051756.p002

    115. Vitamin A Acetate 1.5 M.i.u./g

    116. Ro-1-5275

    117. A16783

    118. D01621

    119. H12041

    120. Vitamin A Acetate 10 Microg/ml In Acetonitrile

    121. Ab00052305-02

    122. Ab00052305_03

    123. Vitamin A Acetate In Gelatin, 500,000 I.u./g

    124. Q7316808

    125. Sr-05000001431-1

    126. Sr-05000001431-3

    127. W-108382

    128. Brd-k65331431-001-01-3

    129. Vitamin A (acetate), Meets Usp Testing Specifications

    130. Vitamin A (as Acetate & Beta Carotene) [vandf]

    131. Retinol Acetate, European Pharmacopoeia (ep) Reference Standard

    132. Retinyl Acetate, Synthetic, Crystalline Solid Or Supercooled Liquid

    133. Retinyl Acetate, United States Pharmacopeia (usp) Reference Standard

    134. Retinyl Acetate, Concentrate (~50% (w/w) In Peanut Oil), ~1500 U/mg

    135. Retinyl Acetate, Solid Or Viscous Liquid, Bioreagent, Synthetic, Suitable For Cell Culture

    136. Retinyl Acetate, Synthetic, Matrix Dispersion, 475,000-650,000 Usp Units/g

    137. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenyl Acetate

    138. 3,7-dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol Acetate, (all Trans)-

    139. Retinyl Acetate (vitamin A Acetate), Pharmaceutical Secondary Standard; Certified Reference Material

    140. Retinyl Acetate Solution, 100 Mug/ml In Ethanol (with 0.1% (w/v) Bht), Ampule Of 1 Ml, Certified Reference Material

    141. Retinyl Acetate Solution, 100 Mug/ml In Ethanol (with 0.1% (w/v) Bht; Degassed), Certified Reference Material

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 328.5 g/mol
    Molecular Formula C22H32O2
    XLogP36.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count7
    Exact Mass328.240230259 g/mol
    Monoisotopic Mass328.240230259 g/mol
    Topological Polar Surface Area26.3 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity596
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count4
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anticarcinogenic Agents

    Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)

    Adjuvants, Immunologic

    Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

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    27-Jan-2022
    30-Jul-2025
    KGS
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    ABOUT THIS PAGE

    Looking for 127-47-9 / Vitamin A Acetate API manufacturers, exporters & distributors?

    Vitamin A Acetate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Vitamin A Acetate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vitamin A Acetate manufacturer or Vitamin A Acetate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vitamin A Acetate manufacturer or Vitamin A Acetate supplier.

    PharmaCompass also assists you with knowing the Vitamin A Acetate API Price utilized in the formulation of products. Vitamin A Acetate API Price is not always fixed or binding as the Vitamin A Acetate Price is obtained through a variety of data sources. The Vitamin A Acetate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Vitamin A Acetate

    Synonyms

    Retinol acetate, 127-47-9, Retinol, acetate, All-trans-retinyl acetate, Crystalets, Vitamin a1 acetate

    Cas Number

    127-47-9

    Unique Ingredient Identifier (UNII)

    3LE3D9D6OY

    About Vitamin A Acetate

    Retinyl Acetate is a naturally-occurring fatty acid ester form of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Retinyl acetate binds to and activates retinoid receptors, inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation in some cancer cell types and exhibits immunomodulatory properties. (NCI04)

    Vitamin A Acetate Manufacturers

    A Vitamin A Acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vitamin A Acetate, including repackagers and relabelers. The FDA regulates Vitamin A Acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vitamin A Acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Vitamin A Acetate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Vitamin A Acetate Suppliers

    A Vitamin A Acetate supplier is an individual or a company that provides Vitamin A Acetate active pharmaceutical ingredient (API) or Vitamin A Acetate finished formulations upon request. The Vitamin A Acetate suppliers may include Vitamin A Acetate API manufacturers, exporters, distributors and traders.

    click here to find a list of Vitamin A Acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Vitamin A Acetate USDMF

    A Vitamin A Acetate DMF (Drug Master File) is a document detailing the whole manufacturing process of Vitamin A Acetate active pharmaceutical ingredient (API) in detail. Different forms of Vitamin A Acetate DMFs exist exist since differing nations have different regulations, such as Vitamin A Acetate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Vitamin A Acetate DMF submitted to regulatory agencies in the US is known as a USDMF. Vitamin A Acetate USDMF includes data on Vitamin A Acetate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Vitamin A Acetate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Vitamin A Acetate suppliers with USDMF on PharmaCompass.

    Vitamin A Acetate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Vitamin A Acetate Drug Master File in Japan (Vitamin A Acetate JDMF) empowers Vitamin A Acetate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Vitamin A Acetate JDMF during the approval evaluation for pharmaceutical products. At the time of Vitamin A Acetate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Vitamin A Acetate suppliers with JDMF on PharmaCompass.

    Vitamin A Acetate CEP

    A Vitamin A Acetate CEP of the European Pharmacopoeia monograph is often referred to as a Vitamin A Acetate Certificate of Suitability (COS). The purpose of a Vitamin A Acetate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Vitamin A Acetate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Vitamin A Acetate to their clients by showing that a Vitamin A Acetate CEP has been issued for it. The manufacturer submits a Vitamin A Acetate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Vitamin A Acetate CEP holder for the record. Additionally, the data presented in the Vitamin A Acetate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Vitamin A Acetate DMF.

    A Vitamin A Acetate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Vitamin A Acetate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Vitamin A Acetate suppliers with CEP (COS) on PharmaCompass.

    Vitamin A Acetate GMP

    Vitamin A Acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Vitamin A Acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vitamin A Acetate GMP manufacturer or Vitamin A Acetate GMP API supplier for your needs.

    Vitamin A Acetate CoA

    A Vitamin A Acetate CoA (Certificate of Analysis) is a formal document that attests to Vitamin A Acetate's compliance with Vitamin A Acetate specifications and serves as a tool for batch-level quality control.

    Vitamin A Acetate CoA mostly includes findings from lab analyses of a specific batch. For each Vitamin A Acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Vitamin A Acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (Vitamin A Acetate EP), Vitamin A Acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vitamin A Acetate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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