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Chemistry

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Also known as: Azd2014, 1009298-59-2, Azd-2014, Vistusertib [inn], Azd 2014, 3-[2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-n-methylbenzamide
Molecular Formula
C25H30N6O3
Molecular Weight
462.5  g/mol
InChI Key
JUSFANSTBFGBAF-IRXDYDNUSA-N
FDA UNII
0BSC3P4H5X

Vistusertib
Vistusertib is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. Vistusertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.
1 2D Structure

Vistusertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide
2.1.2 InChI
InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
2.1.3 InChI Key
JUSFANSTBFGBAF-IRXDYDNUSA-N
2.1.4 Canonical SMILES
CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOCC5C
2.1.5 Isomeric SMILES
C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C
2.2 Other Identifiers
2.2.1 UNII
0BSC3P4H5X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(5,6-e)pyrimidin-7-yl)-n-methylbenzamide

2. Azd-2014

3. Azd2014

2.3.2 Depositor-Supplied Synonyms

1. Azd2014

2. 1009298-59-2

3. Azd-2014

4. Vistusertib [inn]

5. Azd 2014

6. 3-[2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-n-methylbenzamide

7. Vistusertib (azd-2014)

8. Vistusertib [usan]

9. Vistusertib (azd2014)

10. 0bsc3p4h5x

11. Chembl2336325

12. 3-(2,4-bis((s)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-n-methylbenzamide

13. 3-[2,4-bis[(3s)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-n-methylbenzamide

14. Benzamide, 3-(2,4-bis((3s)-3-methyl-4-morpholinyl)pyrido(2,3-d)pyrimidin-7-yl)-n-methyl-

15. 3-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(5,6-e)pyrimidin-7-yl)-n-methylbenzamide

16. Unii-0bsc3p4h5x

17. Cc-551

18. Benzamide, 3-[2,4-bis[(3s)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-n-methyl-

19. 3-[2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido-[5,6-e]pyrimidin-7-yl]-n-methylbenzamide

20. Vistusertib (jan/inn)

21. Vistusertib [jan]

22. Vistusertib [usan:inn]

23. Vistusertib [who-dd]

24. Mls006011011

25. Schembl290672

26. Gtpl7699

27. Dtxsid20143584

28. Ex-a155

29. Amy24188

30. Bcp05748

31. Bdbm50429701

32. Mfcd22628784

33. Nsc767189

34. Nsc780879

35. Nsc787289

36. Nsc799345

37. S2783

38. Zinc59258964

39. Akos024464879

40. Bcp9000362

41. Ccg-269370

42. Cs-0701

43. Db11925

44. Nsc-767189

45. Nsc-780879

46. Nsc-787289

47. Nsc-799345

48. Ncgc00346698-04

49. Ncgc00346698-11

50. Ncgc00346698-12

51. Ac-28425

52. As-16302

53. Hy-15247

54. Smr004702809

55. Sw219704-1

56. D10887

57. J-000268

58. Q27089147

59. 3-[2,4-bis-[(3s)-3-methyl-4-morpholinyl]-pyrido[2,3-d]pyrimidin-7-yl]-n-methylbenzamide

60. 3-(2,4-bis((3s)-3-methyl-4-morpholinyl)pyrido(2,3-d)pyrimidin-7-yl)-n-methylbenzamide

2.4 Create Date
2009-05-18
3 Chemical and Physical Properties
Molecular Weight 462.5 g/mol
Molecular Formula C25H30N6O3
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass462.23793884 g/mol
Monoisotopic Mass462.23793884 g/mol
Topological Polar Surface Area92.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity698
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1009298-59-2 / Vistusertib API manufacturers, exporters & distributors?

Vistusertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vistusertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vistusertib manufacturer or Vistusertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vistusertib manufacturer or Vistusertib supplier.

PharmaCompass also assists you with knowing the Vistusertib API Price utilized in the formulation of products. Vistusertib API Price is not always fixed or binding as the Vistusertib Price is obtained through a variety of data sources. The Vistusertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vistusertib

Synonyms

Azd2014, 1009298-59-2, Azd-2014, Vistusertib [inn], Azd 2014, 3-[2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-n-methylbenzamide

Cas Number

1009298-59-2

Unique Ingredient Identifier (UNII)

0BSC3P4H5X

About Vistusertib

Vistusertib is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. Vistusertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.

Vistusertib Manufacturers

A Vistusertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vistusertib, including repackagers and relabelers. The FDA regulates Vistusertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vistusertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vistusertib Suppliers

A Vistusertib supplier is an individual or a company that provides Vistusertib active pharmaceutical ingredient (API) or Vistusertib finished formulations upon request. The Vistusertib suppliers may include Vistusertib API manufacturers, exporters, distributors and traders.

Vistusertib GMP

Vistusertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vistusertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vistusertib GMP manufacturer or Vistusertib GMP API supplier for your needs.

Vistusertib CoA

A Vistusertib CoA (Certificate of Analysis) is a formal document that attests to Vistusertib's compliance with Vistusertib specifications and serves as a tool for batch-level quality control.

Vistusertib CoA mostly includes findings from lab analyses of a specific batch. For each Vistusertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vistusertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Vistusertib EP), Vistusertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vistusertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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