Vincristine Sulfate

Synopsis, Chemistry

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2 Drug(s) in Development

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51 Dossiers, 20 FDA Orange Book, 13 Europe, 2 Canada, 2 Australia, 5 South Africa, 9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 12 SPI Pharma, 3 Roquette, 2 Microlex e.U, 2 Gangwal Healthcare, 2 Gangwal Chemicals, 2 Kerry, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Rochem International Inc, 1 Sigachi Industries, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Ingredion Pharma Solutions, 1 DKSH, 1 Pfanstiehl, 1 BASF

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18 Fillers, Diluents & Binders, 10 Direct Compression, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 4 Co-Processed Excipients, 3 Parenteral, 3 Granulation, 3 Disintegrants & Superdisintegrants, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

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9 US Medicaid Prescriptions, 10 Finished Drug Prices

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6 APIs, 11 DOSSIERS // FDF

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Also known as: 2068-78-2, Kyocristine, Vincristine sulphate, Vincrisul, Leurocristine sulfate, Oncovin

Molecular Formula

C₄₆H₅₈N₄O₁₄S

Molecular Weight

923.0 g/mol

InChI Key

AQTQHPDCURKLKT-JKDPCDLQSA-N

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

1 2D Structure

Vincristine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

2.1.2 InChI

InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

2.1.3 InChI Key

AQTQHPDCURKLKT-JKDPCDLQSA-N

2.1.4 Canonical SMILES

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Cellcristin

2. Citomid

3. Farmistin

4. Leurocristine

5. Oncovin

6. Oncovine

7. Onkocristin

8. Pfs, Vincasar

9. Sulfate, Vincristine

10. Vincasar

11. Vincasar Pfs

12. Vincristin Bristol

13. Vincristin Medac

14. Vincristine

15. Vincrisul

16. Vintec

2.2.2 Depositor-Supplied Synonyms

1. 2068-78-2

2. Kyocristine

3. Vincristine Sulphate

4. Vincrisul

5. Leurocristine Sulfate

6. Oncovin

7. Onkovin

8. Marqibo

9. 22-oxovincaleukoblastine Sulfate

10. Vcr Sulfate

11. Rel-vincristine Sulfate

12. Nsc 67574

13. Lilly 37231

14. Nsc67574

15. Nsc-67574

16. Leurocristine, Sulfate (1:1) (salt)

17. Alkaloid Extracted From Vinca Rosea Linn

18. Novopharm

19. Chebi:79401

20. 1217704-93-2

21. Mls002702994

22. Lilly-37231

23. Vincristini Sulfas

24. Oncovin (lilly)

25. Vincasar (tn)

26. Marqibo (tn)

27. Oncovin (tn)

28. Vincrex (tn)

29. Vincristine, Sulfate

30. Leurocristine, Sulfate

31. Vincristine Sulphate Salt

32. Vincristine Sulfate Liposome

33. Schembl3710

34. Leurocristine Sulfate (1:1)

35. Chembl501867

36. Dtxsid8044331

37. Vincristine Sulfate (jp17/usp)

38. Hms3414l13

39. Hms3678l11

40. Mfcd08706469

41. Akos015895862

42. V0129

43. Lcr

44. Vcr

45. D02197

46. 068v782

47. A936684

48. Methyl (3ar,3a1r,4r,5s,5ar,10br)-4-acetoxy-3a-ethyl-9-((3s,5s,7s,9s)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2h-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1h-indolizino[8,1-cd]carbazole-5-carboxylate Sulfate

2.3 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₄₆H₅₈N₄O₁₄S
Molecular Weight	923.0 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	10
Exact Mass	922.36702371 g/mol
Monoisotopic Mass	922.36702371 g/mol
Topological Polar Surface Area	254 Å²
Heavy Atom Count	65
Formal Charge	0
Complexity	1830
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Marqibo kit
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable, liposomal
Route	Intravenous
Strength	5mg/5ml (1mg/ml)
Market Status	Prescription
Company	Talon Therap

2 of 4
Drug Name	Vincristine sulfate pfs
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Hospira; Teva Pharms Usa

3 of 4
Drug Name	Marqibo kit
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable, liposomal
Route	Intravenous
Strength	5mg/5ml (1mg/ml)
Market Status	Prescription
Company	Talon Therap

4 of 4
Drug Name	Vincristine sulfate pfs
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Hospira; Teva Pharms Usa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Vinca Alkaloids [CS]; Vinca Alkaloid [EPC]

Find Vincristine Sulfate manufacturers, exporters & distributors on PharmaCompass

Vincristine Sulfate

Vincristine Sulfate

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

22 API Suppliers

11 USDMF

5 CEP/COS

1 JDMF

3 EU WC

4 NDC API

9 Listed Suppliers

DEVELOPMENTS

2 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Imports

DOSSIERs // Finished Dosage Formulations

51 Dossiers

20 FDA Orange Book

13 Europe

2 Canada

2 Australia

5 South Africa

9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers

12 SPI Pharma

3 Roquette

2 Microlex e.U

2 Gangwal Healthcare

2 Gangwal Chemicals

2 Kerry

1 Shijiazhuang Huaxu Pharmaceutical

1 Rochem International Inc

1 Sigachi Industries

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Ingredion Pharma Solutions

1 DKSH

1 Pfanstiehl

1 BASF

EXCIPIENTS BY APPLICATIONS

18 Fillers, Diluents & Binders

10 Direct Compression

10 Chewable & Orodispersible Aids

9 Taste Masking

4 Co-Processed Excipients

3 Parenteral

3 Granulation

3 Disintegrants & Superdisintegrants

1 API Stability Enhancers

1 Thickeners and Stabilizers

GLOBAL SALES INFORMATION

9 US Medicaid Prescriptions

10 Finished Drug Prices

MARKET PLACE

6 APIs

11 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

3 EDQM Standards

2 USP Standards

2 JP Standards

2 Other Ref. Standards

DIGITAL CONTENT

13 News

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

SERVICES

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