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Chemistry

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Also known as: 698394-73-9, Traficet-en, Ccx282-b, Gsk1605786, Gsk-1605786, 4-(2-((4-(tert-butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide
Molecular Formula
C22H21ClN2O4S
Molecular Weight
444.9  g/mol
InChI Key
JRWROCIMSDXGOZ-UHFFFAOYSA-N
FDA UNII
MWI54OUA12

Vercirnon
Vercirnon is a novel, orally active anti-inflammatory agent that targets a chemokine receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of IBD. It is under investigation in clinical trial NCT01611805 (Japanese Phase I of GSK1605786).
1 2D Structure

Vercirnon

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-tert-butyl-N-[4-chloro-2-(1-oxidopyridin-1-ium-4-carbonyl)phenyl]benzenesulfonamide
2.1.2 InChI
InChI=1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3
2.1.3 InChI Key
JRWROCIMSDXGOZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)Cl)C(=O)C3=CC=[N+](C=C3)[O-]
2.2 Other Identifiers
2.2.1 UNII
MWI54OUA12
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ccx282-b

2. Gsk1605786a

3. Traficet-en

2.3.2 Depositor-Supplied Synonyms

1. 698394-73-9

2. Traficet-en

3. Ccx282-b

4. Gsk1605786

5. Gsk-1605786

6. 4-(2-((4-(tert-butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide

7. 4-tert-butyl-n-[4-chloro-2-(1-oxidopyridin-1-ium-4-carbonyl)phenyl]benzenesulfonamide

8. Benzenesulfonamide, N-(4-chloro-2-((1-oxido-4-pyridinyl)carbonyl)phenyl)-4-(1,1-dimethylethyl)-

9. Benzenesulfonamide, N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-

10. Vercirnon [inn]

11. Vercirnon [usan]

12. Vercirnon [who-dd]

13. Mwi54oua12

14. Schembl342225

15. Gtpl9046

16. Chembl2178578

17. Ccx-282-b

18. Dtxsid50220135

19. Gsk'786

20. Ycb39473

21. Bdbm50398334

22. Zinc38562120

23. Cs-4963

24. Db15250

25. Ncgc00485483-01

26. Da-22939

27. Gsk-1605786;ccx282-b

28. Hy-15724

29. Ft-0735140

30. A914682

31. Q27089138

32. 4-(2-(4-tert-butylphenylsulfonamido)-5-chlorobenzoyl)pyridine 1-oxide

33. 4-tert-butyl-n-[4-chloro-2-(1-oxidoisonicotinoyl)phenyl]benzenesulfonamide

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 444.9 g/mol
Molecular Formula C22H21ClN2O4S
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass444.0910560 g/mol
Monoisotopic Mass444.0910560 g/mol
Topological Polar Surface Area97.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Vercirnon, a small molecule, orally-available drug, is intended to control the inappropriate immune system response underlying IBD by blocking the activity of the CCR9 chemokine receptor. In adults, CCR9 is a highly specific receptor expressed by T cells that migrate selectively to the digestive tract. The trafficking of T cells to the small and large intestine causes persistent inflammation that may result in Crohn's disease or ulcerative colitis - the two principal forms of IBD.


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Looking for 698394-73-9 / Vercirnon API manufacturers, exporters & distributors?

Vercirnon manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vercirnon API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vercirnon manufacturer or Vercirnon supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vercirnon manufacturer or Vercirnon supplier.

PharmaCompass also assists you with knowing the Vercirnon API Price utilized in the formulation of products. Vercirnon API Price is not always fixed or binding as the Vercirnon Price is obtained through a variety of data sources. The Vercirnon Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vercirnon

Synonyms

698394-73-9, Traficet-en, Ccx282-b, Gsk1605786, Gsk-1605786, 4-(2-((4-(tert-butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide

Cas Number

698394-73-9

Unique Ingredient Identifier (UNII)

MWI54OUA12

About Vercirnon

Vercirnon is a novel, orally active anti-inflammatory agent that targets a chemokine receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of IBD. It is under investigation in clinical trial NCT01611805 (Japanese Phase I of GSK1605786).

Vercirnon Manufacturers

A Vercirnon manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vercirnon, including repackagers and relabelers. The FDA regulates Vercirnon manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vercirnon API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vercirnon Suppliers

A Vercirnon supplier is an individual or a company that provides Vercirnon active pharmaceutical ingredient (API) or Vercirnon finished formulations upon request. The Vercirnon suppliers may include Vercirnon API manufacturers, exporters, distributors and traders.

Vercirnon GMP

Vercirnon Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vercirnon GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vercirnon GMP manufacturer or Vercirnon GMP API supplier for your needs.

Vercirnon CoA

A Vercirnon CoA (Certificate of Analysis) is a formal document that attests to Vercirnon's compliance with Vercirnon specifications and serves as a tool for batch-level quality control.

Vercirnon CoA mostly includes findings from lab analyses of a specific batch. For each Vercirnon CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vercirnon may be tested according to a variety of international standards, such as European Pharmacopoeia (Vercirnon EP), Vercirnon JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vercirnon USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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