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Venlafaxine Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

85 API Suppliers, 42 USDMF, 43 CEP/COS, 2 JDMF, 25 EU WC, 6 KDMF, 19 NDC API, 28 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

1 Suppliers

1 Suppliers

DOSSIERs // Finished Dosage Formulations

450 Dossiers, 174 FDA Orange Book, 196 Europe, 51 Canada, 7 South Africa, 22 Listed Dossiers

DRUG PRODUCT COMPOSITION

CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE
CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE
CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

RELATED EXCIPIENT COMPANIES

Suppliers, 39 Kerry, 39 BASF, 25 Roquette, 19 SPI Pharma, 17 Seppic, 16 Corel Pharma Chem, 15 Microlex e.U, 13 Gangwal Chemicals, 12 Sigachi Industries, 12 Gangwal Healthcare, 11 Ideal Cures Pvt Ltd, 11 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 Nanjing Well Pharmaceutical, 9 Boai NKY Pharmaceuticals Ltd, 7 DFE Pharma, 7 Actylis, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 6 Lonza Capsugel, 5 Prachin Chemical, 5 Pharmatrans-Sanaq, 5 Ingredion Pharma Solutions, 4 Ulanqab Kema New Material, 4 Kima Chemical, 4 Vasa Pharmachem, 4 ACG Worldwide, 3 The Dow Chemical Company, 3 Jai Radhe Sales, 3 DKSH, 3 Rochem International Inc, 3 Alcedo Pharmachem, 2 Nomisma Healthcare, 2 Seqens, 2 Finar, 2 Vertellus, 2 Clariant, 2 Evonik, 2 Qualicaps, 2 Pfanstiehl, 1 Nanjing Bold Chemical, 1 Minakem, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Aeon Procare, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Shanghai Welltone Material Technology Co., Ltd, 1 NEWEDGE Overseas, 1 Pharm-RX Chemical, 1 Chynops Pharma

EXCIPIENTS BY APPLICATIONS

95 Fillers, Diluents & Binders, 70 Coating Systems & Additives, 46 Direct Compression, 46 Disintegrants & Superdisintegrants, 45 Controlled & Modified Release, 37 Solubilizers, 33 Thickeners and Stabilizers, 32 Granulation, 28 Taste Masking, 25 Topical, 24 Lubricants & Glidants, 22 Film Formers & Plasticizers, 20 Chewable & Orodispersible Aids, 20 Parenteral, 18 Co-Processed Excipients, 10 API Stability Enhancers, 9 Empty Capsules, 8 Emulsifying Agents, 5 Rheology Modifiers, 5 Surfactant & Foaming Agents, 4 Vegetarian Capsules, 2 Coloring Agents

GLOBAL SALES INFORMATION

22 US Medicaid Prescriptions, 29 Finished Drug Prices

MARKET PLACE

5 APIs, 1 DOSSIERS // FDF, 1 EXCIPIENTS

PATENTS

16 Health Canada Patents

16 Health Canada Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 2 EDQM Standards, 1 USP Standards

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1 Data Compilations & Company Tracker #PharmaFlow, 24 News

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INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

174

Europe

196

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

1,315.00

Annual Reports

FDF Market Place

EXCIPIENTS

345

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 99300-78-4, Venlafaxine hcl, Effexor, Efexor, Effexor xr, Dobupal

Molecular Formula

C₁₇H₂₈ClNO₂

Molecular Weight

313.9 g/mol

InChI Key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

FDA UNII

7D7RX5A8MO

A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

1 2D Structure

Venlafaxine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

2.1.3 InChI Key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl

2.2 Other Identifiers

2.2.1 UNII

7D7RX5A8MO

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hcl

2. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

3. Dobupal

4. Efexor

5. Effexor

6. Hydrochloride, Venlafaxine

7. Sila Venlafaxine

8. Sila-venlafaxine

9. Trevilor

10. Vandral

11. Venlafaxine

12. Wy 45,030

13. Wy 45030

14. Wy-45,030

15. Wy-45030

16. Wy45,030

17. Wy45030

2.3.2 Depositor-Supplied Synonyms

1. 99300-78-4

2. Venlafaxine Hcl

3. Effexor

4. Efexor

5. Effexor Xr

6. Dobupal

7. Vandral

8. Venlafaxinehydrochloride

9. Wy-45030

10. Venlafaxine (hydrochloride)

11. Wy 45030

12. Wy-45,030

13. Wy 45030 Hydrochloride

14. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

15. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride

16. Nsc-745751

17. 7d7rx5a8mo

18. Venlafaxine (as Hydrochloride)

19. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol Hydrochloride

20. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

21. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol Hydrochloride

22. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride

23. Chebi:9944

24. Venlafaxine Hydrochloride [usan]

25. Venlafaxine Hydorchloride

26. Unii-7d7rx5a8mo

27. C17h27no2.hcl

28. Venlift

29. Vexor

30. D,l-venlafaxine, Hydrochloride

31. Venlafaxine Ea

32. Venlafaxine Xr

33. Effexor Lp

34. Effexor Xl

35. Efexor Xl

36. Venlafaxine, Hcl

37. Effexor (tn)

38. Venlafaxine Hydrochloride [usan:usp]

39. Venlafaxine Hydro Chloride

40. Dsstox_cid_27397

41. Dsstox_rid_82318

42. Dsstox_gsid_47397

43. Schembl41936

44. Mls001401454

45. Chembl1201066

46. Dtxsid8047397

47. Hy-b0196a

48. Bvf-012

49. Amy32694

50. Bcp21401

51. Dl-venlafaxine Hydrochloride- Bio-x

52. Tox21_302508

53. Tox21_500449

54. Nsc745751

55. S1441

56. Venlafaxine Hydrochloride (jan/usp)

57. Venlafaxine Hydrochloride [mi]

58. Akos000280874

59. Akos016340594

60. Ac-1696

61. Ccg-100979

62. Ccg-213270

63. H13v695

64. Ks-5049

65. Lp00449

66. Nc00229

67. Nsc 745751

68. Pw-4112

69. Venlafaxine Hydrochloride [jan]

70. Venlafaxine Hydrochloride [hsdb]

71. Ncgc00256703-01

72. Ncgc00261134-01

73. Venlafaxine Hydrochloride [mart.]

74. Venlafaxine Hydrochloride [vandf]

75. Bv164514

76. Smr000469154

77. Venlafaxine Hydrochloride [usp-rs]

78. Venlafaxine Hydrochloride [who-dd]

79. Cas-99300-78-4

80. Ft-0642395

81. Sw197609-3

82. V0110

83. Pf-00345408

84. D00821

85. Venlafaxine Hydrochloride [ep Impurity]

86. Venlafaxine Hydrochloride [ep Monograph]

87. Venlafaxine Hydrochloride [orange Book]

88. Venlafaxine Hydrochloride [usp Monograph]

89. A845995

90. Venlafaxine Hydrochloride, >=98% (hplc), Powder

91. Venlafaxine Hydrochloride 100 Microg/ml In Methanol

92. Q27108525

93. Venlafaxine Hydrochloride 100 Microg/ml In Acetonitrile

94. 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol -hcl

95. Venlafaxine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

96. 1-[2-(dimethylamino)-1-(4-methoxyph Enyl)ethyl]cyclohexanol Hydrochloride

97. 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol Hydrochloride

98. Venlafaxine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

99. (+/-)-1-(.alpha.-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol Hydrochloride

100. (rs)-1-(2-dimethylamino-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

101. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-1-cyclohexanol Hydrochloride

102. Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, Hydrochloride (1:1

103. Venlafaxine For System Suitability, European Pharmacopoeia (ep) Reference Standard

104. Venlafaxine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

105. Venlafaxine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

106. Venlafaxine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₈ClNO₂
Molecular Weight	313.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	313.1808568 g/mol
Monoisotopic Mass	313.1808568 g/mol
Topological Polar Surface Area	32.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	279
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Effexor xr
Drug Label	Effexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 150mg base; eq 37.5mg base; eq 75mg base
Market Status	Prescription
Company	Wyeth Pharms

2 of 4
Drug Name	Venlafaxine hydrochloride
PubMed Health	Venlafaxine (By mouth)
Drug Classes	Antidepressant
Drug Label	Venlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Tablet, extended release; Tablet; Capsule, extended release
Route	oral; Oral
Strength	37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

3 of 4
Drug Name	Effexor xr
Drug Label	Effexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 150mg base; eq 37.5mg base; eq 75mg base
Market Status	Prescription
Company	Wyeth Pharms

4 of 4
Drug Name	Venlafaxine hydrochloride
PubMed Health	Venlafaxine (By mouth)
Drug Classes	Antidepressant
Drug Label	Venlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Tablet, extended release; Tablet; Capsule, extended release
Route	oral; Oral
Strength	37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]