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UREA, C-13

UREA, C-13

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Also known as: Urea-13c, 58069-82-2, Urea c 13, 13c-urea, Urea, c-13, Carbon-13 urea

Molecular Formula

CH₄N₂O

Molecular Weight

61.048 g/mol

InChI Key

XSQUKJJJFZCRTK-OUBTZVSYSA-N

FDA UNII

W6KX9E6D8X

Urea C-13 is a radiolabelled urea molecule used to diagnose stomach ulcers caused by Heliobacter pylori. In the presence of H. pylori, urea C-13 is metabolized by urease to produce ammonia and radioactive carbon dioxide at the interface between the gastric epithelium and lumen. The radioactive carbon dioxide is absorbed in the blood and is detected when exhaled in the breath.

Urea c-13 is a Helicobacter pylori Diagnostic.

1 2D Structure

UREA C-13

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

diamino(113C)methanone

2.1.2 InChI

InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)/i1+1

2.1.3 InChI Key

XSQUKJJJFZCRTK-OUBTZVSYSA-N

2.1.4 Canonical SMILES

C(=O)(N)N

2.1.5 Isomeric SMILES

[13C](=O)(N)N

2.2 Other Identifiers

2.2.1 UNII

W6KX9E6D8X

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Urea-13c

2. 58069-82-2

3. Urea C 13

4. 13c-urea

5. Urea, C-13

6. Carbon-13 Urea

7. Urea (13c)

8. Diamino(113c)methanone

9. Urea 13 C

10. Helicosol

11. 13-c Urea

12. 13-c-urea

13. Carbone (13) Urea

14. (13c) Urea

15. Urea ((sup 13)c)

16. W6kx9e6d8x

17. Chebi:32285

18. Carbamide-13c

19. Pylobactell

20. Urea (13c) (jan)

21. Urea (13c) [jan]

22. C13-urea

23. Urea C13

24. Helicobacter Test Infai

25. Unii-w6kx9e6d8x

26. Urea C 13 [usp]

27. Pylori-chek

28. Helicosol (tn)

29. Carbon 13 Urea

30. Carbonyldiamide-13c

31. (13c)urea

32. Urea C13 (usp)

33. ((13)c)urea

34. Urea-[13c]

35. (~13~c)carbamimidic Acid

36. Chembl2096648

37. Urea 13 C [who-dd]

38. Urea C 13 [usp-rs]

39. 13-c Urea [ema Epar]

40. Dtxsid20973641

41. Urea C-13 [orange Book]

42. Amy37002

43. Urea C 13 [usp Impurity]

44. Urea C 13 [usp Monograph]

45. Mfcd00064398

46. Akos030254865

47. Idkit:hp Component Urea C-13

48. Db09510

49. Urea C-13 Component Of Idkit:hp

50. As-77784

51. C-13

52. Hy-118877

53. Urea-13c, 99 Atom % 13c, Ubt Grade

54. Cs-0069967

55. Urea-13c, Research Grade, 99 Atom % 13c

56. D01749

57. Q27114855

58. Urea C 13, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	CH₄N₂O
Molecular Weight	61.048 g/mol
XLogP3	-1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	61.035717591 g/mol
Monoisotopic Mass	61.035717591 g/mol
Topological Polar Surface Area	69.1 Å²
Heavy Atom Count	4
Formal Charge	0
Complexity	29
Isotope Atom Count	1
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Urea-13C is indicated for use in the qualitative detection of urease associated with Helicobacter pylori in the human stomach and as an aid in the initial diagnosis and post-treatment monitoring of Helicobacter pylori infection in adult patients. The test may be used for monitoring treatment if used at least four (4) weeks following completion of therapy. For these purposes, the system utilizes an Infrared Spectrophotometer for the measurement of the ratio of 13CO2 to 12CO2 in breath samples.

FDA Label

This medicinal product is for diagnostic use only.

For in vivo diagnosis of gastroduodenal Helicobacter pylori (H. pylori) infection.

Helicobacter Test INFAI may be used for in vivo diagnosis of gastroduodenal Helicobacter pylori infection in:

- adults;

- adolescents, who are likely to have peptic ulcer disease.

Helicobacter Test INFAI for children aged three to 11 years may be used for in vivo diagnosis of gastrduodenal Helicobacter pylori infection:

- for the evaluation of the success of eradication treatment, or;

- when invasive tests cannot be performed, or;

- when there are discordant results arising from invasive tests.

This medicinal product is for diagnostic use only.

Pylori-Chek may be used for in vivo diagnosis of gastroduodenal Helicobacter pylori infection.

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Active Moiety

UREA C-13

5.1.2 FDA UNII

W6KX9E6D8X

5.1.3 Pharmacological Classes

Chemical Structure [CS] - Urea

5.2 ATC Code

V04CX

V - Various

V04 - Diagnostic agents

V04C - Other diagnostic agents

V04CX - Other diagnostic agents

V04CX05 - 13C-urea

5.3 Mechanism of Action

The Urea Breath Test is based on the ability of the H. pylori enzyme urease to cleave urea into ammonia and carbon dioxide. As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that H. pylori bacteria are present. To detect H. pylori, urea labeled with 13C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 13CO2 is absorbed into the blood and exhaled in the breath. Exhaled breath samples can then be collected and measured for the presence of radioactivity.