Evonik Evonik

X

Find Tyloxapol API manufacturers, exporters & distributors on PharmaCompass

PharmaCompass
API SUPPLIERS
API Suppliers

API Suppliers

0

US DMFs Filed

US DMFs Filed

0

CEP/COS Certifications

CEP/COS Certifications

0

JDMFs Filed

JDMFs Filed

0

EU WC

EU WC

0

Listed Suppliers

Listed Suppliers

0

API REF. PRICE (USD / KG)
INTERMEDIATES

0

DOSSIERS // FDF
USA (Orange Book)

USA (Orange Book)

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Uploaded Dossiers

Uploaded Dossiers

0

GLOBAL SALES (USD Million)

U.S. Medicaid

0

Annual Reports

0

EXCIPIENTS

0

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

0

USFDA Exclusivities

0

DIGITAL CONTENT

Blog #PharmaFlow

0

News

0

REF STANDARD

EDQM

0

USP

JP

0

Other Listed Suppliers

SERVICES

0

Tyloxapol API
Also known as: Tyloxapol, 25301-02-4, Tyloxypal, Triton wr-1339, Superinone, Alevaire
Molecular Formula
C17H28O3
Molecular Weight
280.4  g/mol
InChI Key
MDYZKJNTKZIUSK-UHFFFAOYSA-N

Tyloxapol is a non-ionic detergent often used as a surfactant.
1 2D Structure

Tyloxapol API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
2.1.2 InChI
InChI=1S/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2
2.1.3 InChI Key
MDYZKJNTKZIUSK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Alevaire

2. Enuclene

3. Formaldehyde, Polymer With Oxirane And 4-(1,1,3,3-tetramethylbutyl)phenol

4. Oxyethylated Tertiary Octylphenol Formaldehyde Polymer

5. P-isooctylpolyoxyethylenephenol Formaldehyde Polymer

6. Polyhydroxyethyl-tert-octylphenolformaldehyde

7. Superinone

8. Supervent

9. Translight

10. Triton A 20

11. Triton Wr 1339

12. Triton Wr-1339

13. Tyloxapol

14. Tyroxapol

15. Wr-1339

2.2.2 Depositor-Supplied Synonyms

1. Tyloxapol

2. 25301-02-4

3. Tyloxypal

4. Triton Wr-1339

5. Superinone

6. Alevaire

7. Nsc90255

8. Formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol

9. Triton A-20

10. Formaldehyde, Polymer With Oxirane And4-(1,1,3,3-tetramethylbutyl)phenolother Ca Index Names:oxirane, Polymer With Formaldehyde And4-(1,1,3,3-tetramethylbutyl)phenolphenol, 4-(1,1,3,3-tetramethylbutyl)-, Polymer With Formaldehyde Andoxirane

11. Superiuone

12. Component Of Alevaire

13. Formaldehyde; Oxirane; 4-(1,1,3,3-tetramethylbutyl)phenol

14. Schembl181284

15. Dtxsid30179950

16. Chebi:141517

17. Nsc-90255

18. Akos026749862

19. Formaldehyde,1,3,3-tetra Methylbutyl)phenol

20. Ab01563398_01

21. Q7860340

22. Ethoxylated P-tert-octylphenol Formaldehyde Polymer

23. Wln: /qr Dx1&1&1x1&1&1/ &/*o2*/ &/*o1*/

24. Phenol,1,3,3-tetramethylbutyl)-, Polymer With Ethylene Oxide And Formaldehyde

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 280.4 g/mol
Molecular Formula C17H28O3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass280.20384475 g/mol
Monoisotopic Mass280.20384475 g/mol
Topological Polar Surface Area49.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity204
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Tyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.


5 Pharmacology and Biochemistry
5.1 Pharmacology

It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.


5.2 MeSH Pharmacological Classification

Surface-Active Agents

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)


Detergents

Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)


5.3 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05C - Expectorants, excl. combinations with cough suppressants

R05CA - Expectorants

R05CA01 - Tyloxapol


5.4 Mechanism of Action

Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.


Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty
Post Enquiry
POST ENQUIRY