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Triprolidine Hcl

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Also known as: Triprolidine hcl, 6138-79-0, Actidil, Myidyl, Triprolidine.hcl monohydrate, Trans-triprolidinehydrochloride

Molecular Formula

C₁₉H₂₅ClN₂O

Molecular Weight

332.9 g/mol

InChI Key

CUZMOIXUFHOLLN-UMVVUDSKSA-N

FDA UNII

YAN7R5L890

Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

1 2D Structure

Triprolidine Hcl

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrate;hydrochloride

2.1.2 InChI

InChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;

2.1.3 InChI Key

CUZMOIXUFHOLLN-UMVVUDSKSA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.O.Cl

2.1.5 Isomeric SMILES

CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.O.Cl

2.2 Other Identifiers

2.2.1 UNII

YAN7R5L890

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Actidil

2. Anhydrous, Triprolidine Hydrochloride

3. Hydrochloride Anhydrous, Triprolidine

4. Hydrochloride, Triprolidine

5. Pro Actidil

6. Triprolidine

7. Triprolidine Hydrochloride

8. Triprolidine Hydrochloride Anhydrous

9. Triprolidine Monohydrochloride

10. Triprolidine Monohydrochloride, (z)-isomer

11. Triprolidine Monohydrochloride, Monohydrate

12. Triprolidine Oxalate

13. Triprolidine Oxalate, (trans)-isomer

14. Triprolidine, (z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. Triprolidine Hcl

2. 6138-79-0

3. Actidil

4. Myidyl

5. Triprolidine.hcl Monohydrate

6. Trans-triprolidinehydrochloride

7. Triprolidine Hydrochloride Hydrate

8. Yan7r5l890

9. Chebi:32265

10. (e)-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride Monohydrate

11. Nsc-757361

12. Pro-actidil

13. Pro-entra

14. Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride, Monohydrate, (e)-

15. 2-[(1e)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridine Hydrochloride Hydrate

16. Triprolidine Hydrochloride Hydrate (jan)

17. Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, Monohydrochloride, Monohydrate, (e)-

18. Ccris 7215

19. Triprolidine Hydrochloride Hydrate [jan]

20. Triprolidine (hydrochloride Monohydrate)

21. Unii-yan7r5l890

22. Actidilon

23. Triprolidine Hydrochloride [usp:jan]

24. Venen (tn)

25. Dsstox_cid_1410

26. Dsstox_rid_76146

27. Dsstox_gsid_21410

28. Triprolidinehydrochloridehydrate

29. Schembl1140974

30. Chembl3188034

31. Dtxsid0021410

32. Triprolidine Hydrochloride (usp)

33. Triprolidinhydrochlorid Monohydrat

34. Hy-b1301

35. Tox21_200848

36. S5447

37. Akos024370814

38. Ccg-267838

39. Nsc 757361

40. W38t790

41. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine Hydrochloride Hydrate

42. Ncgc00258402-01

43. Bs-17733

44. Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, Monohydrochloride, Monohydrate, Stereoisomer

45. Triprolidine Hydrochloride [mart.]

46. Triprolidine Hydrochloride [vandf]

47. Cas-6138-79-0

48. Triprolidine Hydrochloride [usp-rs]

49. Cs-0013069

50. D01782

51. D70442

52. Triprolidine Hydrochloride [orange Book]

53. Myfed Component Triprolidine Hydrochloride

54. Actifed Component Triprolidine Hydrochloride

55. Corphed Component Triprolidine Hydrochloride

56. Triphed Component Triprolidine Hydrochloride

57. Triprolidine Hydrochloride [usp Monograph]

58. Triprolidine Hydrochloride Monohydrate [mi]

59. Actahist Component Triprolidine Hydrochloride

60. Allerfed Component Triprolidine Hydrochloride

61. Histafed Component Triprolidine Hydrochloride

62. Trilitron Component Triprolidine Hydrochloride

63. Triprolidine Hydrochloride Component Of Myfed

64. Q27114841

65. Triacin-c Component Triprolidine Hydrochloride

66. Triprolidine Hydrochloride Component Of Actahist

67. Triprolidine Hydrochloride Component Of Actifed

68. Triprolidine Hydrochloride Component Of Allerfed

69. Triprolidine Hydrochloride Component Of Corphed

70. Triprolidine Hydrochloride Component Of Histafed

71. Triprolidine Hydrochloride Component Of Triphed

72. Triprolidine Hydrochloride Monohydrate [mart.]

73. Triprolidine Hydrochloride Monohydrate [who-dd]

74. Triprolidine Hydrochloride Component Of Triacin-c

75. Triprolidine Hydrochloride Component Of Trilitron

76. Triprolidine Hydrochloride Monohydrochloride Monohydrate

77. (e)-2-[3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl]pyridine Hydrochloride Monohydrate

78. 1-[(2e)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium Chloride--water (1/1)

79. 2-[(1e)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine Hydrochloride--water (1/1)

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₅ClN₂O
Molecular Weight	332.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	332.1655411 g/mol
Monoisotopic Mass	332.1655411 g/mol
Topological Polar Surface Area	17.1 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	336
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)