Find Alimemazine manufacturers, exporters & distributors on PharmaCompass

Trimeprazine Tartrate

Trimeprazine Tartrate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

8 API Suppliers, 3 USDMF, 1 CEP/COS, 1 JDMF, 9 NDC API, 6 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

11 Dossiers, 5 FDA Orange Book, 2 Europe, 3 Canada, 1 South Africa

MARKET PLACE

3 APIs

3 APIs

ANALYTICAL SOLUTION(s)

1 USP Standards, 3 Other Ref. Standards

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

700

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Trimeprazine tartrate, 4330-99-8, Trimeprazine hemitartrate salt, Nsc-17475, Nsc-757358, Prestwick_144

Molecular Formula

C₄₀H₅₀N₄O₆S₂

Molecular Weight

747.0 g/mol

InChI Key

AJZJIYUOOJLBAU-UHFFFAOYSA-N

1 2D Structure

Trimeprazine Tartrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,3-dihydroxybutanedioic acid;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine

2.1.2 InChI

InChI=1S/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)

2.1.3 InChI Key

AJZJIYUOOJLBAU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C.CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Temaril

2. Theralen

3. Theraline

4. Trimeprazine Tartrate

2.2.2 Depositor-Supplied Synonyms

1. Trimeprazine Tartrate

2. 4330-99-8

3. Trimeprazine Hemitartrate Salt

4. Nsc-17475

5. Nsc-757358

6. Prestwick_144

7. Chembl3989885

8. Hms1570j05

9. Hms3714j05

10. Trimeprazine Hemi-(+)-tartrate Salt

11. Ccg-220842

2.3 Create Date

2006-04-14

3 Chemical and Physical Properties

Molecular Formula	C₄₀H₅₀N₄O₆S₂
Molecular Weight	747.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	11
Exact Mass	746.31717767 g/mol
Monoisotopic Mass	746.31717767 g/mol
Topological Polar Surface Area	179 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	445
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)