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1. Tri-mellitic Anhydride
1. 552-30-7
2. 1,2,4-benzenetricarboxylic Anhydride
3. Anhydrotrimellic Acid
4. 1,3-dioxo-1,3-dihydroisobenzofuran-5-carboxylic Acid
5. Trimellitic Acid Anhydride
6. 4-carboxyphthalic Anhydride
7. Tman
8. Trimellitic Acid 1,2-anhydride
9. Anhydrotrimellitic Acid
10. Trimellic Acid Anhydride
11. Trimellic Acid 1,2-anhydride
12. 1,3-dioxo-5-phthalancarboxylic Acid
13. Trimellitic Acid Cyclic 1,2-anhydride
14. 5-isobenzofurancarboxylic Acid, 1,3-dihydro-1,3-dioxo-
15. 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid
16. 1,2,4-benzenetricarboxylic Acid Anhydride
17. Epon 9150
18. 1,2,4-benzenetricarboxylic Acid 1,2-anhydride
19. Nci-c56633
20. 1,3-dioxo-2-benzofuran-5-carboxylic Acid
21. 1,3-dioxo-1,3-dihydro-2-benzofuran-5-carboxylic Acid
22. Nsc 60252
23. 1,2,4-benzenetricarboxylic Acid, Cyclic 1,2-anhydride
24. 5-phthalanacarboxylic Acid, 1,3-dioxo-
25. Chebi:53050
26. Benzene-1,2,4-tricarboxylic-1,2-anhydride
27. Mfcd00005925
28. 1,3-dioxoisobenzofuran-5-carboxylic Acid
29. 1,2,4-benzenetricarboxylic 1,2-anhydride
30. 80t61euu7h
31. Diphenylmethane-4,4'-diisocyanate-trimellic Anhydride-ethomid Ht Polymer
32. Nsc-60252
33. 1,2,4-benzene Tricarboxylic Anhydride
34. Benzene-1,2,4-tricarboxylic Anhydride
35. Benzene-1,2,4-tricarboxylic Acidanhydride
36. Dsstox_cid_6235
37. Dsstox_rid_78070
38. Dsstox_gsid_26235
39. 1,3-dioxo-1,3-dihydro-isobenzofuran-5-carboxylic Acid
40. Anhydride-ethomid Ht Polymer
41. Cas-552-30-7
42. Ccris 6282
43. Hsdb 4299
44. 1,2,4-benzenetricarboxylicanhydride
45. Einecs 209-008-0
46. Benzene-1,2,4-tricarboxylic Acid 1,2-anhydride
47. Brn 0009394
48. Unii-80t61euu7h
49. Cyclic 1,2-anhydride
50. Epitope Id:113235
51. Ec 209-008-0
52. Schembl22458
53. Trimellitic Acid,2-anhydride
54. 5-18-08-00562 (beilstein Handbook Reference)
55. Trimellic Acid-1,2-anhydride
56. Wln: T56 Bvovj Gvq
57. Trimellitic Anhydride-dendrimers
58. Chembl2137687
59. Dtxsid7026235
60. Trimellitic Anhydride Treated Bsa
61. Trimellitic Anhydride Treated Hsa
62. Trimellitic Anhydride Treated Igg
63. 1,4-benzenetricarboxylic Anhydride
64. Trimellitic Anhydride [mi]
65. Nsc60252
66. Trimellitic Anhydride Treated Casein
67. Tox21_202066
68. Tox21_303117
69. Trimellitic Anhydride [hsdb]
70. Trimellitic Anhydride [inci]
71. 5-phthalanacarboxylic Acid,3-dioxo-
72. Ac-811
73. Ac8872
74. Bbl010496
75. Stl146149
76. Zinc22346496
77. 1,2,4 Benzenetricarboxylic Anhydride
78. Akos000120069
79. Cs-w015822
80. Trimellitic Anhydride Treated Hemoglobin
81. 1,4-benzenetricarboxylic Acid Anhydride
82. Benzene-1,2,4-tricarboxylicacidanhydride
83. Ncgc00164022-01
84. Ncgc00164022-02
85. Ncgc00256953-01
86. Ncgc00259615-01
87. 1,3-dioxo-5-isobenzofurancarboxylic Acid
88. Bp-13468
89. Sy001151
90. Trimellitic Anhydride-trypsin Treated Bsa
91. Vs-02531
92. 1,2,4 Benzenetricarboxylic Acid Anhydride
93. 1,2,4-benzenetricarboxylic Anhydride, 97%
94. 1,4-benzenetricarboxylic Acid 1,2-anhydride
95. C0959
96. Ft-0689091
97. Trimellitic Anhydride Treated Human Transferrin
98. Trimellitic Anhydride, Purum, >=97.0% (t)
99. 1,2,4-benzenetricarboxylic Acid Anhydride-1,2
100. Trimellitic Anhydride Treated Human Serum Albumin
101. A830542
102. Trimellitic Anhydride Treated Bovine Serum Albumin
103. Q1675143
104. W-105576
105. 1,4-benzenetricarboxylic Acid, Cyclic 1,2-anhydride
106. 5-isobenzofurancarboxylic Acid,3-dihydro-1,3-dioxo-
107. Trimellitic Anhydride Treated Non-fat Dry Milk Powder
108. 1,2,4-benzenetricarboxylic Anhydride Treated Hemoglobin
109. F0001-1448
110. 1,3-dioxo-1,3-dihydro-isobenzofuran-5-carboxylic Acid #
111. Trimellitic Anhydride-trypsin Treated Bovine Serum Albumin
112. 1,2,4-benzenetricarboxylic Anhydride Trimellitic Anhydride Tma
113. 1,3-dioxoisobenzofuran-5-carboxylic Acid;trimellitic Anhydride
114. Trimellitic Anhydride Treated .beta.-lactoglobulin From Bovine Whey
115. 1,2,4-benzenetricarboxylic Anhydride Treated .beta.-lactoglobulin From Bovine Whey
| Molecular Weight | 192.12 g/mol |
|---|---|
| Molecular Formula | C9H4O5 |
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 1 |
| Exact Mass | 192.00587322 g/mol |
| Monoisotopic Mass | 192.00587322 g/mol |
| Topological Polar Surface Area | 80.7 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 308 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Tissue concentration time-course data were collected for rats exposed to 0.95 mg/cu m trimellitic anhydride (TMA) for 45 min ... Animals were sacrificed 3 hr, 1, 2, 4, 8, 16, and 32 days following exposure. In general, the highest tissue concentrations were obtained at the first time point (T-max<3 hr). A second T-max of eight days was reported for lung lymph nodes in male rats, suggesting a possible role in the gender differences observed for lung toxicity ...
OECD; Screening Information Data Set for Trimellitic anhydride & trimellitic acid, CAS #: 552-30-7; 528-44-9 (October 2002). Available from, as of August 28, 2006: https://www.inchem.org/documents/sids/sids/TLANA.pdf
... Biological half-lives /in rats/ ranging from 3 to 46 days were estimated ... Specific half-lives for trimellitic anhydride in the lungs were estimated to be 21 days in male rats and 16 days in female rats ... In lung associated lymph nodes, half-lives of 13 and 33 days were estimated for male and female rats, respectively ...
OECD; Screening Information Data Set for Trimellitic anhydride & trimellitic acid, CAS #: 552-30-7; 528-44-9 (October 2002). Available from, as of August 28, 2006: https://www.inchem.org/documents/sids/sids/TLANA.pdf
... Trimellitic anhydride (TMA) and trimellitic acid (TMLA) are structurally similar ... Studies on stability of TMA in water suggest complete hydrolysis occurs in less than ten minutes. Since TMA rapidly forms TMLA under the conditions used to test its toxicity, the toxicities of TMA and TMLA are believed to be the same with a few exceptions. Specifically, the alergic symptoms (both respiratory and dermal sensitization) of TMA are directly attributable to the reaction of TMA with free amines within proteins to form haptens, which when present at sufficiently high levels in tissues can produce sensitization. TMLA does not react with proteins to form haptens ... In addition to the immunological differences, there may be some slight quantitative differences in reactions at the site of contact. While both materials cause slight irritation of the skin and are severe eye irritants, there appears to be a difference in the magnitude of response. This difference in the magnitude of irritation may be attributable to the heat of hydrolysis of the anhydride. With the exception of the immunological and site of contact effects, all other endpoints are expected to be the same.
OECD; Screening Information Data Set for Trimellitic anhydride & trimellitic acid, CAS #: 552-30-7; 528-44-9 (October 2002). Available from, as of August 28, 2006: https://www.inchem.org/documents/sids/sids/TLANA.pdf
Occupational inhalation of trimellitic anhydride (TMA) apparently results in an antibody response with specificity for unique new antigenic determinants which arise from the coupling of TMA with autologous resp tract proteins.
ZEISS ET AL; INT ARCH ALLERGY APPL IMMUNOL 61(4) 380 (1980)
... Sensitization with trimellitic anhydride (TMA) led to decreased lung function parameters during and within 1 hr after challenge as compared to non-sensitized rats. Alveolar macrophages (AM) depletion alleviated the TMA-induced drop in lung function parameters and induced a faster recovery compared to sham-depleted TMA-sensitized rats. It also decreased the levels of serum IgE 24 hr after challenge, but did not affect the sensitization-dependent increase in lung lavage fluid IL-6 and tissue TNF-alpha levels. AM depletion augmented the TMA-induced tissue damage and inflammation 24 hr after challenge.
PMID:15992840 Valstar DL et al; Toxicol Appl Pharmacol 211 (1): 20-9 (2006)
... In the TNF-alpha knockout TNF-alpha-/- (B6;129S-Tnftm1Gk1) mice, the repetition of the trimellitic anhydride (TMA) challenges enlarged the extent of the late phase of contact hypersensitivity (CHS), but less than those in TNF-alpha+/+ mice. Injection of anti-TNF-alpha antibody into the peritoneal cavity of Balb/c mice significantly decreased the extent of the late phase of CHS. Subcutaneous injection of anti-IgE antibody into Balb/c mice also decreased the extent of the late phase of CHS in dose-dependent manner. Histologically, infiltration of polymorphonuclear leukocytes and eosinophils was more pronounced in repeatedly TMA-challenged TNF-alpha+/+ and Balb/c mice than in the TNF-alpha-/- mice and anti-TNF-alpha or anti-IgE antibodies treated Balb/c mice.
PMID:16264265 Chai OH et al; Exp Mol Med 37 (5): 408-17 (2005)
For more Mechanism of Action (Complete) data for TRIMELLITIC ANHYDRIDE (6 total), please visit the HSDB record page.
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