Triiodothyronine

Synopsis, Chemistry

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1 Drug(s) in Development

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49 Dossiers, 28 FDA Orange Book, 8 Europe, 4 Canada, 1 Australia, 3 South Africa, 5 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - EQ 0.005MG BASE, TABLET;ORAL - EQ 0.025MG BASE, TABLET;ORAL - EQ 0.05MG BASE, INJECTABLE;INJECTION - EQ 0.01MG BASE/ML

TABLET;ORAL - EQ 0.005MG BASE
TABLET;ORAL - EQ 0.025MG BASE
TABLET;ORAL - EQ 0.05MG BASE
INJECTABLE;INJECTION - EQ 0.01MG BASE/ML

RELATED EXCIPIENT COMPANIES

Suppliers, 28 Roquette, 17 Kerry, 17 SPI Pharma, 14 Microlex e.U, 10 Corel Pharma Chem, 9 Sigachi Industries, 8 Gangwal Healthcare, 7 Seppic, 6 Lonza Capsugel, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 5 BASF, 4 ACG Worldwide, 3 DKSH, 3 Ingredion Pharma Solutions, 3 Kima Chemical, 3 Vasa Pharmachem, 2 Pfanstiehl, 2 Qualicaps, 2 Rochem International Inc, 2 Prachin Chemical, 2 The Dow Chemical Company, 2 Actylis, 2 DFE Pharma, 1 Aeon Procare, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Pharmatrans-Sanaq

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57 Fillers, Diluents & Binders, 45 Coating Systems & Additives, 30 Direct Compression, 21 Controlled & Modified Release, 20 Lubricants & Glidants, 20 Taste Masking, 17 Thickeners and Stabilizers, 16 Chewable & Orodispersible Aids, 15 Granulation, 12 Co-Processed Excipients, 11 Disintegrants & Superdisintegrants, 9 Film Formers & Plasticizers, 9 Empty Capsules, 5 Parenteral, 5 API Stability Enhancers, 4 Vegetarian Capsules, 3 Solubilizers, 3 Emulsifying Agents, 2 Coloring Agents, 2 Rheology Modifiers, 1 Topical

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15 US Medicaid Prescriptions, 19 Finished Drug Prices

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13 APIs, 1 DOSSIERS // FDF

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1 BioAnalytical Methods, 3 EDQM Standards, 1 USP Standards, 2 Other Ref. Standards

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Also known as: 55-06-1, Cytomel, Triostat, 3,3',5-triiodo-l-thyronine sodium salt, Tertroxin, T3 sodium salt

Molecular Formula

C₁₅H₁₁I₃NNaO₄

Molecular Weight

672.95 g/mol

InChI Key

SBXXSUDPJJJJLC-YDALLXLXSA-M

FDA UNII

GCA9VV7D2N

A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

1 2D Structure

Triiodothyronine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

2.1.2 InChI

InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

2.1.3 InChI Key

SBXXSUDPJJJJLC-YDALLXLXSA-M

2.1.4 Canonical SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+]

2.1.5 Isomeric SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])N)I)I)O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

GCA9VV7D2N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,3',5-triiodothyronine

2. Cytomel

3. Liothyronine

4. T3 Thyroid Hormone

5. Thyroid Hormone, T3

6. Triiodothyronine

2.3.2 Depositor-Supplied Synonyms

1. 55-06-1

2. Cytomel

3. Triostat

4. 3,3',5-triiodo-l-thyronine Sodium Salt

5. Tertroxin

6. T3 Sodium Salt

7. Basoprocin

8. Ibiothyron

9. Cynomel

10. Triiodothyronine Sodium

11. L-triiodothyronine Sodium Salt

12. Cytobin

13. 3,3',5-triiodo-l-thyronine Sodium

14. 3,3',5-triiodothyronine Sodium Salt

15. Triiodothyronine Sodium Salt

16. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Monosodium Salt

17. Liotrix (t3)

18. Chebi:6484

19. Liothyronine (sodium)

20. Monosodium L-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine

21. Gca9vv7d2n

22. Liothyronine (l- Isomer) Sodium

23. Rathyronine Sodium, (s)-

24. Cytomel Sodium

25. Lyothyronin

26. Nsc-80774

27. Nsc-758175

28. 3,3'',5-triiodo-l-thyronine Sodium Salt

29. Ro Thyronine

30. Sodium Triiodothyronine

31. Liothyronine Sodium Salt

32. Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, Monosodium Salt, L-

33. Sodium Liothyronine

34. Sodium T3

35. Sodium Triiodotironine

36. Sodium-l-triiodothyronine

37. Mls000028648

38. L-triiodothyronine Hydrochloride

39. Sodium (s)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate

40. Rathyronine Hydrochloride, (s)-

41. Sodium Triiodothyronine, L-

42. Sodium 3,5,3'-triiodothyronine

43. Sodium L-3,5,3'-triiodothyronine

44. Smr000059206

45. Einecs 200-223-5

46. Unii-gca9vv7d2n

47. Mfcd00002594

48. Nsc 80774

49. Sodium 3,3',5-triiodo-l-thyronine

50. Sodium 3,5,3'-triiodo-l-thyronine

51. L-3,3',5-triiodothyronine Sodium Salt

52. Triostat (tn)

53. Cytomel (tn)

54. Liothyronine Sodium [usp:ban:jan]

55. Ibiot

56. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Sodium Salt (1:1)

57. Sodium;(2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

58. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine Sodium Salt

59. T-3

60. Epitope Id:136777

61. T3 (liotrix)

62. T3, Na

63. Dsstox_cid_27505

64. Dsstox_rid_82385

65. Dsstox_gsid_47505

66. Schembl41654

67. 3,3',5-l-triiodothyronine

68. Spectrum1502047

69. Chembl1201119

70. Dtxsid8047505

71. Liothyronine Sodium [jan]

72. Nrp-409

73. Liothyronine Sodium (jp17/usp)

74. Hms1921h18

75. Hms2092b14

76. Liothyronine Sodium [vandf]

77. Act03263

78. Amy38143

79. Hy-a0070

80. Liothyronine Sodium [mart.]

81. Sodium L-3,3',5-triiodothyronine

82. Tox21_302514

83. Triiodothyronine Sodium, Levo

84. Ccg-39522

85. Liothyronine Sodium [usp-rs]

86. Liothyronine Sodium [who-dd]

87. Liotrix (t3) [orange Book]

88. S4217

89. Liothyronine Sodium Salt [mi]

90. Akos015918421

91. Akos032949712

92. Cs-3241

93. 3,3',5-triiodo-l-thyronine (sodium)

94. Cas-55-06-1

95. Liothyronine Sodium [green Book]

96. Liothyronine Sodium [orange Book]

97. Ncgc00256816-01

98. Ac-31934

99. As-13674

100. L-3,3',5-triiodothyronine, Sodium Salt

101. Liothyronine Sodium [ep Monograph]

102. Liothyronine Sodium [usp Monograph]

103. 3,5,3'-triiodo-l-thyronine Monosodium Salt

104. Sw219577-1

105. D01011

106. F20556

107. A830467

108. Q930170

109. Q-201881

110. 3,3',5-triiodo-l-thyronine Sodium Salt, >=95% (hplc)

111. Liothyronine Sodium, European Pharmacopoeia (ep) Reference Standard

112. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine, Monosodium Salt

113. 3,3',5-triiodo-l-thyronine Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

114. Liothyronine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

115. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate

116. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

117. 3,3',5-triiodo-l-thyronine Sodium Salt, Gamma-irradiated, Powder, Bioxtra, Suitable For Cell Culture

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₁I₃NNaO₄
Molecular Weight	672.95 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	672.7720 g/mol
Monoisotopic Mass	672.7720 g/mol
Topological Polar Surface Area	95.6 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	408
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Cytomel
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet
Route	Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base
Market Status	Prescription
Company	King Pharms R And D

2 of 6
Drug Name	Liothyronine sodium
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
Market Status	Prescription
Company	X Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

3 of 6
Drug Name	Triostat
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Active Ingredient	Liothyronine sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 0.01mg base/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 6
Drug Name	Cytomel
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet
Route	Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base
Market Status	Prescription
Company	King Pharms R And D

5 of 6
Drug Name	Liothyronine sodium
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
Market Status	Prescription
Company	X Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

6 of 6
Drug Name	Triostat
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Active Ingredient	Liothyronine sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 0.01mg base/ml
Market Status	Prescription
Company	Par Sterile Products

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

l-Triiodothyronine [EPC]; Triiodothyronine [CS]

5.2 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H03 - Thyroid therapy

H03A - Thyroid preparations

H03AA - Thyroid hormones

H03AA02 - Liothyronine sodium

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Triiodothyronine

Triiodothyronine

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

14 API Suppliers

6 USDMF

3 CEP/COS

1 JDMF

3 EU WC

1 KDMF

8 NDC API

6 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

DOSSIERs // Finished Dosage Formulations

49 Dossiers

28 FDA Orange Book

8 Europe

4 Canada

1 Australia

3 South Africa

5 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - EQ 0.005MG BASE

TABLET;ORAL - EQ 0.025MG BASE

TABLET;ORAL - EQ 0.05MG BASE

INJECTABLE;INJECTION - EQ 0.01MG BASE/ML

RELATED EXCIPIENT COMPANIES

Suppliers

28 Roquette

17 Kerry

17 SPI Pharma

14 Microlex e.U

10 Corel Pharma Chem

9 Sigachi Industries

8 Gangwal Healthcare

7 Seppic

6 Lonza Capsugel

6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

6 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

5 BASF

4 ACG Worldwide

3 DKSH

3 Ingredion Pharma Solutions

3 Kima Chemical

3 Vasa Pharmachem

2 Pfanstiehl

2 Qualicaps

2 Rochem International Inc

2 Prachin Chemical

2 The Dow Chemical Company

2 Actylis

2 DFE Pharma

1 Aeon Procare

1 Qianhao Chemical (Hebei) Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Pharmatrans-Sanaq

EXCIPIENTS BY APPLICATIONS

57 Fillers, Diluents & Binders

45 Coating Systems & Additives

30 Direct Compression

21 Controlled & Modified Release

20 Lubricants & Glidants

20 Taste Masking

17 Thickeners and Stabilizers

16 Chewable & Orodispersible Aids

15 Granulation

12 Co-Processed Excipients

11 Disintegrants & Superdisintegrants

9 Film Formers & Plasticizers

9 Empty Capsules

5 Parenteral