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Chemistry

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Also known as: 749-13-3, Triperidol, Trisedil, Psychoperidol, Flumoperone, Psicoperidol
Molecular Formula
C22H23F4NO2
Molecular Weight
409.4  g/mol
InChI Key
GPMXUUPHFNMNDH-UHFFFAOYSA-N
FDA UNII
R8869Q7R8I

Trifluperidol
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)
1 2D Structure

Trifluperidol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one
2.1.2 InChI
InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
2.1.3 InChI Key
GPMXUUPHFNMNDH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC1(C2=CC(=CC=C2)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
2.2 Other Identifiers
2.2.1 UNII
R8869Q7R8I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Trisedil

2.3.2 Depositor-Supplied Synonyms

1. 749-13-3

2. Triperidol

3. Trisedil

4. Psychoperidol

5. Flumoperone

6. Psicoperidol

7. Trisedyl

8. Psicoperidol-r

9. Mcn-jr-2498

10. Trifluperidolo

11. R-2498

12. Nsc 170978

13. P 459

14. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one

15. Nsc-170978

16. Chembl15023

17. 1-butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-

18. R8869q7r8i

19. Nsc170978

20. Triperidol (tn)

21. 4-fluoro-4,4-idrossi-4-(m-trifluorometil-fenil)-piperidino-butirrofenone

22. Trifluperidolum

23. Trifluperidolo [dcit]

24. Trifluperidolo [italian]

25. 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one

26. 1-butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-

27. Trifluperidolum [inn-latin]

28. Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino)-

29. Butyrophenone, 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]-

30. Trifluperidol [usan:inn:ban]

31. Brn 1556208

32. Unii-r8869q7r8i

33. .psi.coperidol

34. 1-(4-fluorophenyl)-4-{4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl}butan-1-one

35. .psi.coperidol-r

36. 4'-fluoro-4-(4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino)butyrophenone

37. 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]butyrophenone

38. Lopac-t-103

39. Trifluperidol [mi]

40. Trifluperidol [inn]

41. Trifluperidol (usan/inn)

42. 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)butyrophenone

43. 4-fluoro-4,4-idrossi-4-(m-trifluorometil-fenil)-piperidino-butirrofenone [italian]

44. Trifluperidol [usan]

45. Lopac0_001243

46. 5-21-02-00406 (beilstein Handbook Reference)

47. Schembl120862

48. Trifluperidol [mart.]

49. Trifluperidol [who-dd]

50. Dtxsid4023703

51. Chebi:135662

52. Hms2090p16

53. Bcp28492

54. Bdbm50047016

55. Ccg-205317

56. Db13552

57. Sdccgsbi-0051210.p002

58. Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-

59. Ncgc00015983-01

60. Ncgc00015983-02

61. Ncgc00015983-03

62. Ncgc00015983-06

63. Ncgc00162376-01

64. Wln: T6ntj A3vr Df& Dq Dr Cxfff

65. 1st161655

66. Ns00010654

67. D02625

68. Ab00918346-05

69. L001285

70. Q4463264

71. Brd-k43605761-003-05-4

72. R-2498; R 2498; R2498

73. Butyrophenone,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]-

74. 1-(4-fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-butan-1-one

75. 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-1-butanone

76. 1-(4-fluorophenyl)-4-(4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl)-1-butanone #

77. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]-butan-1-one

78. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one

79. 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]butyrophenone

80. 1-(4-fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-butan-1-one (trifluperidol)

81. 1-butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-pi Peridinyl]-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 409.4 g/mol
Molecular Formula C22H23F4NO2
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area40.5
Heavy Atom Count29
Formal Charge0
Complexity537
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


4.2 ATC Code

N - Nervous system

N05 - Psycholeptics

N05A - Antipsychotics

N05AD - Butyrophenone derivatives

N05AD02 - Trifluperidol


ABOUT THIS PAGE

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Trifluperidol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Trifluperidol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Trifluperidol manufacturer or Trifluperidol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Trifluperidol manufacturer or Trifluperidol supplier.

PharmaCompass also assists you with knowing the Trifluperidol API Price utilized in the formulation of products. Trifluperidol API Price is not always fixed or binding as the Trifluperidol Price is obtained through a variety of data sources. The Trifluperidol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Trifluperidol

Synonyms

749-13-3, Triperidol, Trisedil, Psychoperidol, Flumoperone, Psicoperidol

Cas Number

749-13-3

Unique Ingredient Identifier (UNII)

R8869Q7R8I

About Trifluperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)

Trifluperidol Manufacturers

A Trifluperidol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trifluperidol, including repackagers and relabelers. The FDA regulates Trifluperidol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trifluperidol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trifluperidol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trifluperidol Suppliers

A Trifluperidol supplier is an individual or a company that provides Trifluperidol active pharmaceutical ingredient (API) or Trifluperidol finished formulations upon request. The Trifluperidol suppliers may include Trifluperidol API manufacturers, exporters, distributors and traders.

click here to find a list of Trifluperidol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trifluperidol GMP

Trifluperidol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trifluperidol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trifluperidol GMP manufacturer or Trifluperidol GMP API supplier for your needs.

Trifluperidol CoA

A Trifluperidol CoA (Certificate of Analysis) is a formal document that attests to Trifluperidol's compliance with Trifluperidol specifications and serves as a tool for batch-level quality control.

Trifluperidol CoA mostly includes findings from lab analyses of a specific batch. For each Trifluperidol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trifluperidol may be tested according to a variety of international standards, such as European Pharmacopoeia (Trifluperidol EP), Trifluperidol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trifluperidol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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