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Trientine Hydrochloride
Also known as: Triethylenetetramine dihydrochloride, 38260-01-4, Syprine, Trientine dihydrochloride, Trientine hcl, Mk-0681
Molecular Formula
C6H20Cl2N4
Molecular Weight
219.15  g/mol
InChI Key
WYHIICXRPHEJKI-UHFFFAOYSA-N
FDA UNII
HC3NX54582

An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
1 2D Structure

Trientine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride
2.1.2 InChI
InChI=1S/C6H18N4.2ClH/c7-1-3-9-5-6-10-4-2-8;;/h9-10H,1-8H2;2*1H
2.1.3 InChI Key
WYHIICXRPHEJKI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CNCCNCCN)N.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
HC3NX54582
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Syprine

2. Trien

3. Trientine

4. Trientine Dihydrochloride

5. Triethylenetetramine

2.3.2 Depositor-Supplied Synonyms

1. Triethylenetetramine Dihydrochloride

2. 38260-01-4

3. Syprine

4. Trientine Dihydrochloride

5. Trientine Hcl

6. Mk-0681

7. 1,2-ethanediamine, N,n'-bis(2-aminoethyl)-, Dihydrochloride

8. Triethylene Tetramine Dihydrochloride

9. Teta

10. N,n'-bis(2-aminoethyl)-1,2-ethanediamine Dihydrochloride

11. Hc3nx54582

12. Nsc-759164

13. N1,n1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine) Dihydrochloride

14. Trien Dihydrochloride

15. Cuprid

16. 1,2-ethanediamine,n1,n2-bis(2-aminoethyl)-, Hydrochloride (1:2)

17. Trientine Hydrochloride [usan]

18. Einecs 253-854-3

19. Mk 0681

20. N,n'-bis(2-aminoethyl)ethylenediamine Dihydrochloride

21. Laszarin

22. Metalite

23. Unii-hc3nx54582

24. Trientine-2hcl

25. 2,2'-ethylenediiminobis(ethylamine) Dihydrochloride

26. Syprine (tn)

27. Trientine Hydrochloride [usan:usp]

28. Trientinedihydrochloride

29. Triethyl Enetetramine 2hcl

30. Schembl506189

31. Chebi:9706

32. Chembl3989777

33. Dtxsid2057863

34. Amy3335

35. Tja-250

36. Mk-681

37. N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride

38. S6585

39. Trientine Hydrochloride (jp17/usp)

40. Trientine Hydrochloride [jan]

41. Trientine Dihydrochloride [mi]

42. Akos028109579

43. Ccg-213505

44. Nsc 759164

45. Trientine Hydrochloride [vandf]

46. Trientine Hydrochloride [usp-rs]

47. Trientine Dihydrochloride [mart.]

48. Bs-49370

49. Trientine Dihydrochloride [who-dd]

50. Db-049259

51. Ft-0639448

52. Trientine Hydrochloride [orange Book]

53. D00736

54. E78246

55. Trientine Hydrochloride [usp Monograph]

56. 260t014

57. Q27279855

58. N1,n1'-(ethane-1,2-diyl)diethane-1,2-diamine Dihydrochloride

59. N\'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine,dihydrochloride

60. Trientine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

61. Triethylenetetramine Dihydrochloride, Puriss., 2xcryst., >=99.0% (at)

62. Trientine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 219.15 g/mol
Molecular Formula C6H20Cl2N4
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass218.1065020 g/mol
Monoisotopic Mass218.1065020 g/mol
Topological Polar Surface Area76.1 Ų
Heavy Atom Count12
Formal Charge0
Complexity49.7
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameSyprine
PubMed HealthTrientine (By mouth)
Drug ClassesHeavy Metal Chelator
Drug LabelTrientine hydrochloride is N,N'-bis (2-aminoethyl)-1,2-ethanediamine dihydrochloride. It is a white to pale yellow crystalline hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chlor
Active IngredientTrientine hydrochloride
Dosage FormCapsule
RouteOral
Strength250mg
Market StatusPrescription
CompanyAton

2 of 2  
Drug NameSyprine
PubMed HealthTrientine (By mouth)
Drug ClassesHeavy Metal Chelator
Drug LabelTrientine hydrochloride is N,N'-bis (2-aminoethyl)-1,2-ethanediamine dihydrochloride. It is a white to pale yellow crystalline hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chlor
Active IngredientTrientine hydrochloride
Dosage FormCapsule
RouteOral
Strength250mg
Market StatusPrescription
CompanyAton

4.2 Drug Indication

Cufence is indicated for the treatment of Wilsons disease in patients intolerant to D-Penicillamine therapy, in adults and children aged 5 years or older.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Metal Chelator [EPC]; Metal Chelating Activity [MoA]
5.3 ATC Code

A16A


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