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Chemistry

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Also known as: Trc253, 2110426-27-0, Gng9gq9y27, Trc-253 [who-dd], Trc-253, Jnj-63576253 (free base)
Molecular Formula
C23H21F3N6O2S
Molecular Weight
502.5  g/mol
InChI Key
OUEHJEYKNYQVRC-UHFFFAOYSA-N
FDA UNII
GNG9GQ9Y27

TRC253
Androgen Receptor Antagonist TRC253 is an orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.
1 2D Structure

TRC253

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[8-oxo-5-(6-piperidin-4-yloxypyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
2.1.2 InChI
InChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2
2.1.3 InChI Key
OUEHJEYKNYQVRC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
GNG9GQ9Y27
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Trc253

2. 2110426-27-0

3. Gng9gq9y27

4. Trc-253 [who-dd]

5. Trc-253

6. Jnj-63576253 (free Base)

7. Jnj63576253 Hcl

8. 5-[8-oxo-5-(6-piperidin-4-yloxypyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile

9. Unii-gng9gq9y27

10. Chembl4858811

11. Schembl19128768

12. Bdbm493530

13. Ex-a1808

14. Nsc831271

15. Akos037652172

16. Nsc-831271

17. Us10981926, Cpd No. 43

18. Ac-36765

19. Hy-115282

20. Cs-0034880

21. 5-[5-oxo-8-[6-(4-piperidyloxy)- 3-pyridyl]-7-thioxo-6,8- Diazaspiro[3.4]octan-6-yl]-3- (trifluoromethyl)pyridine-2- Carbonitrile

2.4 Create Date
2017-10-07
3 Chemical and Physical Properties
Molecular Weight 502.5 g/mol
Molecular Formula C23H21F3N6O2S
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass502.13987959 g/mol
Monoisotopic Mass502.13987959 g/mol
Topological Polar Surface Area127 Ų
Heavy Atom Count35
Formal Charge0
Complexity884
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2110426-27-0 / TRC253 API manufacturers, exporters & distributors?

TRC253 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of TRC253 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right TRC253 manufacturer or TRC253 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred TRC253 manufacturer or TRC253 supplier.

PharmaCompass also assists you with knowing the TRC253 API Price utilized in the formulation of products. TRC253 API Price is not always fixed or binding as the TRC253 Price is obtained through a variety of data sources. The TRC253 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

TRC253

Synonyms

2110426-27-0, Gng9gq9y27, Trc-253 [who-dd], Trc-253, Jnj-63576253 (free base), Jnj63576253 hcl

Cas Number

2110426-27-0

Unique Ingredient Identifier (UNII)

GNG9GQ9Y27

About TRC253

Androgen Receptor Antagonist TRC253 is an orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.

TRC253 Manufacturers

A TRC253 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TRC253, including repackagers and relabelers. The FDA regulates TRC253 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TRC253 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TRC253 Suppliers

A TRC253 supplier is an individual or a company that provides TRC253 active pharmaceutical ingredient (API) or TRC253 finished formulations upon request. The TRC253 suppliers may include TRC253 API manufacturers, exporters, distributors and traders.

TRC253 GMP

TRC253 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TRC253 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TRC253 GMP manufacturer or TRC253 GMP API supplier for your needs.

TRC253 CoA

A TRC253 CoA (Certificate of Analysis) is a formal document that attests to TRC253's compliance with TRC253 specifications and serves as a tool for batch-level quality control.

TRC253 CoA mostly includes findings from lab analyses of a specific batch. For each TRC253 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TRC253 may be tested according to a variety of international standards, such as European Pharmacopoeia (TRC253 EP), TRC253 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TRC253 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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