Trandolapril Mixture With Verapamil

Synopsis, Chemistry

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8 Dossiers, 8 FDA Orange Book

DRUG PRODUCT COMPOSITION

TABLET, EXTENDED RELEASE;ORAL - 1MG;240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 2MG;180MG, TABLET, EXTENDED RELEASE;ORAL - 2MG;240MG, TABLET, EXTENDED RELEASE;ORAL - 4MG;240MG

TABLET, EXTENDED RELEASE;ORAL - 1MG;240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 2MG;180MG
TABLET, EXTENDED RELEASE;ORAL - 2MG;240MG
TABLET, EXTENDED RELEASE;ORAL - 4MG;240MG

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Also known as: Trandolapril mixture with verapamil, Verapamil mixture with trandolapril, Trandolapril/verapamil hydrochloride er, Trandolapril mixture with verapamil hcl, Trandolapril plus verapamil hydrochloride, Trandolapril-verapamil hydrochloride mixt.

Molecular Formula

C₅₁H₇₃ClN₄O₉

Molecular Weight

921.6 g/mol

InChI Key

PPAGZPRHIOKKLV-WDFOJNLTSA-N

1 2D Structure

Trandolapril Mixture With Verapamil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

2.1.2 InChI

InChI=1S/C27H38N2O4.C24H34N2O5.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29;/h9-12,17-18,20H,8,13-16H2,1-7H3;4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29);1H/t;16-,18+,19-,20-,21-;/m.0./s1

2.1.3 InChI Key

PPAGZPRHIOKKLV-WDFOJNLTSA-N

2.1.4 Canonical SMILES

CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O.CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

2.1.5 Isomeric SMILES

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O.CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Trandolapril Mixture With Verapamil

2. Verapamil Mixture With Trandolapril

3. Trandolapril/verapamil Hydrochloride Er

4. Trandolapril Mixture With Verapamil Hcl

5. Trandolapril Plus Verapamil Hydrochloride

6. Trandolapril-verapamil Hydrochloride Mixt.

7. Trandolapril Mixture With Verapamil Hydrochloride

8. Schembl2526928

9. 146994-90-3

10. 1h-indole-2-carboxylic Acid, 1-((2s)-2-(((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2s,3ar,7as)-, Mixt. With Alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Monohydrochloride

2.3 Create Date

2008-07-11

3 Chemical and Physical Properties

Molecular Formula	C₅₁H₇₃ClN₄O₉
Molecular Weight	921.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	23
Exact Mass	920.5066076 g/mol
Monoisotopic Mass	920.5066076 g/mol
Topological Polar Surface Area	160 Å²
Heavy Atom Count	65
Formal Charge	0
Complexity	1240
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE
Active Ingredient	TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Company	GLENMARK GENERICS (Application Number: A079135)

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

Angiotensin-converting Enzyme Inhibitors [MoA]; Calcium Channel Antagonists [MoA]; Calcium Channel Blocker [EPC]; Cytochrome P450 3A Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; P-Glycoprotein Inhibitors [MoA]; Angiotensin Converting Enzyme Inhibitor [EPC]