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    TPGS Vitamin E
    Also known as: Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)
    Molecular Formula
    C35H58O6
    Molecular Weight
    574.8  g/mol
    InChI Key
    AOBORMOPSGHCAX-UHFFFAOYSA-N
    Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.
    1 2D Structure

    TPGS Vitamin E

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
    2.1.2 InChI
    InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
    2.1.3 InChI Key
    AOBORMOPSGHCAX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    2. Alpha-d-tocopherol Poly(ethylene Glycol) 2000 Succinate

    3. Alpha-tocopheryl Polyethylene Glycol Succinate

    4. Mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) Succinate Polyethylene Glycol Monoester

    5. Poly(oxy-1,2-ethanediyl), Alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-

    6. Tocofersolan

    7. Tocopherol Poly(ethylene Glycol) 2000 Succinate

    8. Tocopherol Polyethylene Glycol Succinate

    9. Tocophersolan, (2r-(2r*(4r*,8r*)))-isomer

    10. Tocopheryl Poly(ethylene Glycol) 1000 Succinate

    11. Tpgs

    12. Tpgs 2k

    13. Vitamin E-tpgs

    14. Vitamine E Peg-1000-succinate

    2.2.2 Depositor-Supplied Synonyms

    1. Vitamin E Tpgs

    2. Tpgs

    3. Tocophersolan [usan]

    4. Tocofersolan (inn)

    5. 30999-06-5

    6. Tocophersolan (usan)

    7. 1-o-(2-hydroxyethyl) 4-o-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] Butanedioate

    8. Tocofersolan [inn]

    9. Poly(oxy-1,2-ethanediyl),a-[4-[[(2r)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-2h-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

    10. Tocofersolano

    11. Tocofersolanum

    12. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    13. Tocofersolan, Inn

    14. Tocophersolan, Usan

    15. Alpha-tocopheryl Polyethylene Glycol Succinate

    16. Alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    17. Schembl3139787

    18. Aquasol E Tpgs Liquid 77iu/ml

    19. Dtxsid50860035

    20. Chebi:176233

    21. Bcp11679

    22. Akos015967005

    23. Ft-0675259

    24. Tocopheryl Polyethylene Glycol 1000 Succinate

    25. D06174

    26. Q172409

    27. D-alpha-tocopheryl Poly(ethylene Glycol) 1000 Succinate

    28. D-alpha-tocopheryl Poly(ethylene Glycol)1000 Succinate

    29. 1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

    30. 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

    31. D08cvc;d-(c) Paragraph Sign-tocopherol Polyethylene Glycol 1000 Succinate; Tpgs; Vitamin E-tpgs

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 574.8 g/mol
    Molecular Formula C35H58O6
    XLogP39.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count20
    Exact Mass574.42333957 g/mol
    Monoisotopic Mass574.42333957 g/mol
    Topological Polar Surface Area82.1 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity768
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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    PMC Isochem Isodel TPGS Vitamin E

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