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Chemistry

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Also known as: 1207284-17-0, Y6ium7395q, (2s)-n-[(5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl]-1-methylpyrrolidine-2-carboxamide, (s)-n-((5ar,6as,7s,10as)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-yl)-1-methylpyrrolidine-2-carboxamide, Unii-y6ium7395q, (2s)-n-((5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl)-1-methylpyrrolidine-2-carboxamide
Molecular Formula
C27H31FN4O8
Molecular Weight
558.6  g/mol
InChI Key
VIWUYPVRNWIKLS-HMFHYXQTSA-N
FDA UNII
Y6IUM7395Q

TP-271
TP-271 is under investigation in clinical trial NCT02724085 (A Phase 1 Study to Assess the Safety, Tolerability and PK of IV TP-271).
1 2D Structure

TP-271

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-N-[(5aR,6aS,7S,10aR)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-1-methylpyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C27H31FN4O8/c1-31(2)19-12-8-10-7-11-13(28)9-14(30-26(39)15-5-4-6-32(15)3)20(33)17(11)21(34)16(10)23(36)27(12,40)24(37)18(22(19)35)25(29)38/h9-10,12,15,19,33-34,37,40H,4-8H2,1-3H3,(H2,29,38)(H,30,39)/t10-,12-,15-,19-,27-/m0/s1
2.1.3 InChI Key
VIWUYPVRNWIKLS-HMFHYXQTSA-N
2.1.4 Canonical SMILES
CN1CCCC1C(=O)NC2=CC(=C3CC4CC5C(C(=O)C(=C(C5(C(=O)C4=C(C3=C2O)O)O)O)C(=O)N)N(C)C)F
2.1.5 Isomeric SMILES
CN1CCC[C@H]1C(=O)NC2=CC(=C3C[C@H]4C[C@H]5[C@@H](C(=O)C(=C([C@]5(C(=O)C4=C(C3=C2O)O)O)O)C(=O)N)N(C)C)F
2.2 Other Identifiers
2.2.1 UNII
Y6IUM7395Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2s)-n-((5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl)-1-methylpyrrolidine-2-carboxamide

2.3.2 Depositor-Supplied Synonyms

1. 1207284-17-0

2. Y6ium7395q

3. (2s)-n-[(5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl]-1-methylpyrrolidine-2-carboxamide

4. (s)-n-((5ar,6as,7s,10as)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-yl)-1-methylpyrrolidine-2-carboxamide

5. Unii-y6ium7395q

6. (2s)-n-((5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl)-1-methylpyrrolidine-2-carboxamide

7. Chembl2057236

8. Schembl13397803

9. Gtpl11013

10. Tp271

11. Db15040

2.4 Create Date
2011-12-26
3 Chemical and Physical Properties
Molecular Weight 558.6 g/mol
Molecular Formula C27H31FN4O8
XLogP31.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass558.21259212 g/mol
Monoisotopic Mass558.21259212 g/mol
Topological Polar Surface Area194 Ų
Heavy Atom Count40
Formal Charge0
Complexity1220
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1207284-17-0 / TP-271 API manufacturers, exporters & distributors?

TP-271 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of TP-271 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right TP-271 manufacturer or TP-271 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred TP-271 manufacturer or TP-271 supplier.

PharmaCompass also assists you with knowing the TP-271 API Price utilized in the formulation of products. TP-271 API Price is not always fixed or binding as the TP-271 Price is obtained through a variety of data sources. The TP-271 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

TP-271

Synonyms

1207284-17-0, Y6ium7395q, (2s)-n-[(5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl]-1-methylpyrrolidine-2-carboxamide, (s)-n-((5ar,6as,7s,10as)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-yl)-1-methylpyrrolidine-2-carboxamide, Unii-y6ium7395q, (2s)-n-((5ar,6as,7s,10ar)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5h-tetracen-2-yl)-1-methylpyrrolidine-2-carboxamide

Cas Number

1207284-17-0

Unique Ingredient Identifier (UNII)

Y6IUM7395Q

About TP-271

TP-271 is under investigation in clinical trial NCT02724085 (A Phase 1 Study to Assess the Safety, Tolerability and PK of IV TP-271).

TP-271 Manufacturers

A TP-271 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TP-271, including repackagers and relabelers. The FDA regulates TP-271 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TP-271 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TP-271 Suppliers

A TP-271 supplier is an individual or a company that provides TP-271 active pharmaceutical ingredient (API) or TP-271 finished formulations upon request. The TP-271 suppliers may include TP-271 API manufacturers, exporters, distributors and traders.

TP-271 GMP

TP-271 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TP-271 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TP-271 GMP manufacturer or TP-271 GMP API supplier for your needs.

TP-271 CoA

A TP-271 CoA (Certificate of Analysis) is a formal document that attests to TP-271's compliance with TP-271 specifications and serves as a tool for batch-level quality control.

TP-271 CoA mostly includes findings from lab analyses of a specific batch. For each TP-271 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TP-271 may be tested according to a variety of international standards, such as European Pharmacopoeia (TP-271 EP), TP-271 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TP-271 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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