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1. Acid, Benzoic
2. Benzoate, Potassium
3. Potassium Benzoate
4. Ucephan
1. 65-85-0
2. Dracylic Acid
3. Benzenecarboxylic Acid
4. Carboxybenzene
5. Benzeneformic Acid
6. Phenylformic Acid
7. Benzenemethanoic Acid
8. Phenylcarboxylic Acid
9. Benzoate
10. Retardex
11. Benzoesaeure Gk
12. Benzoesaeure Gv
13. Retarder Ba
14. Tenn-plas
15. Acide Benzoique
16. Salvo Liquid
17. Solvo Powder
18. Benzoesaeure
19. Flowers Of Benzoin
20. Flowers Of Benjamin
21. Benzoic Acid, Tech.
22. Unisept Bza
23. Ha 1 (acid)
24. Kyselina Benzoova
25. Benzoic Acid (natural)
26. Benzoate (van)
27. Fema No. 2131
28. Ha 1
29. Benzoesaeure [german]
30. Caswell No. 081
31. Diacylic Acid
32. Oracylic Acid
33. Acide Benzoique [french]
34. Acido Benzoico [italian]
35. Benzenemethonic Acid
36. Kyselina Benzoova [czech]
37. Nsc 149
38. E 210
39. Vevovitall
40. Ccris 1893
41. Diacylate
42. Hsdb 704
43. Menno-florades
44. Benzoicum Acidum
45. Ai3-0310
46. Salvo, Liquid
47. Solvo, Powder
48. Ai3-03710
49. Phenyl Formic Acid
50. Epa Pesticide Chemical Code 009101
51. E210
52. Chebi:30746
53. Nsc-149
54. Aromatic Carboxylic Acid
55. Mfcd00002398
56. 8skn0b0mim
57. Benzoic Acid (e 210)
58. Ins No.210
59. Ins-210
60. Benzeneformate
61. Phenylformate
62. Benzenemethanoate
63. Phenylcarboxylate
64. Benzenecarboxylate
65. Benzoic Acid 100 Microg/ml In Acetone
66. Dsstox_cid_143
67. E-210
68. Dsstox_rid_75396
69. Dsstox_gsid_20143
70. Acido Benzoico
71. Carboxypolystyrene
72. Benzoic Acid [usan:jan]
73. Cas-65-85-0
74. Nsc7918
75. Benzoic Acid (tn)
76. Benzoic Acid Natural
77. Einecs 200-618-2
78. Unii-8skn0b0mim
79. Benzoic Acid [usp:jan]
80. Phenylcarboxy
81. Dracylate
82. Benzoic Aicd
83. Benzoic-acid
84. Bezoic Acid
85. Aromatic Acid
86. Benzenecarboxylic
87. Salvo Powder
88. Acidum Benzoicum
89. Benzoic- Acid
90. Retarder Bax
91. 1gyx
92. 1kqb
93. Benzoic Acid Usp
94. Sodium Benzoic Acid
95. Benzoic Acid,(s)
96. Natural Benzoic Acid
97. Benzoic Acid Solution
98. Benzoicacid-d5
99. Benzoic Acid-[13c7]
100. Wln: Qvr
101. Benzene-2-carboxylic Acid
102. Benzoic Acid-[18o2]
103. Benzoic Acid [ii]
104. Benzoic Acid [mi]
105. Benzoic Acid, Acs Reagent
106. Bmse000300
107. Chembl541
108. Epitope Id:139965
109. Ec 200-618-2
110. Benzoic Acid [fcc]
111. Benzoic Acid [jan]
112. Schembl1378
113. Benzoic Acid [fhfi]
114. Benzoic Acid [hsdb]
115. Benzoic Acid [inci]
116. Sampl4, O1
117. Benzoic Acid (jp17/usp)
118. Benzoic Acid [vandf]
119. Mls002415717
120. Benzoic Acid [mart.]
121. Bidd:er0597
122. Benzoic Acid [usp-rs]
123. Benzoic Acid [who-dd]
124. Benzoic Acid [who-ip]
125. Benzoic Acid, Ar, >=99%
126. Benzoic Acid, Lr, >=99%
127. Nsc149
128. Zinc1011
129. Benzoicum Acidum [hpus]
130. Dtxsid6020143
131. Fema 2131
132. Benzoic Acid (7ci,8ci,9ci)
133. Benzoic Acid, Analytical Standard
134. Benzoic Acid, P.a., 99.5%
135. Benzoic Acid [green Book]
136. Bdbm197302
137. Benzoic-2,3,4,5,6-d5 Acid
138. Hms2092f18
139. Hms2267d03
140. Hms3652b03
141. Pharmakon1600-01503001
142. Benzoic Acid [ep Monograph]
143. Hy-n0216
144. Tox21_202403
145. Tox21_300180
146. Benzoic Acid [usp Monograph]
147. Nsc758203
148. S4161
149. Stk301730
150. Benzoic Acid, Reagentplus(r), 99%
151. Akos000119619
152. Bs-3752
153. Ccg-213088
154. Db03793
155. Nsc-758203
156. Acidum Benzoicum [who-ip Latin]
157. Benzoic Acid, >=99.5%, Fcc, Fg
158. Benzoic Acid, Acs Reagent, >=99.5%
159. Ncgc00091886-01
160. Ncgc00091886-02
161. Ncgc00091886-03
162. Ncgc00254112-01
163. Ncgc00259952-01
164. Tiaprofenic Acid Impurity D [ep]
165. 5-isobenzofurancarboxylic Acid, 1,3-dihydro-1,3-dioxo-, Polymer With 1,3-isobenzofurandione And 1,1'-methylenebis[4-isocyanatobenzene], Reaction Products With Benzoic Acid
166. Benzoic Acid 1000 Microg/ml In Ethanol
167. Benzoic Acid, Usp, 99.5-100.5%
168. Bp-30148
169. Smr001252220
170. Sy009192
171. Benzoic Acid, Tested According To Ph.eur.
172. Sbi-0206720.p001
173. Benzoic Acid 100 Microg/ml In Acetonitrile
174. Benzoic Acid, Saj First Grade, >=99.5%
175. Db-029471
176. B0062
177. B2635
178. Cs-0008257
179. Ft-0622705
180. Ft-0662569
181. Ft-0662570
182. Ft-0770591
183. Sw219833-1
184. Benzoic Acid, Natural, >=99.5%, Fcc, Fg
185. Benzoic Acid, Saj Special Grade, >=99.5%
186. Benzoic Acid, Vetec(tm) Reagent Grade, 98%
187. Benzoic Acid, Meets Usp Testing Specifications
188. Benzoic Acid, Purified By Sublimation, >=99%
189. C00180
190. C00539
191. D00038
192. D85168
193. Mefenamic Acid Impurity D [ep Impurity]
194. Ab00949635_05
195. Ab00949635_06
196. Benzoic Acid 2000 Microg/ml In Dichloromethane
197. A835250
198. A934445
199. Benzoic Acid Zone Refined (number Of Passes:20)
200. Q191700
201. Sr-05000001919
202. Benzoic Acid, Puriss. P.a., Acs Reagent, 99.9%
203. Sr-05000001919-1
204. 0be368dc-6de6-4927-aecf-e4bb2968a4a0
205. Glycopyrronium Bromide Impurity D [ep Impurity]
206. Melting Point Standard 121-123c, Analytical Standard
207. Metronidazole Benzoate Impurity C [ep Impurity]
208. Z57127480
209. F2191-0092
210. Hydrous Benzoyl Peroxide Impurity B [ep Impurity]
211. Benzoic Acid, Nist(r) Srm(r) 39j, Calorimetric Standard
212. Benzoic Acid, Standard For Quantitative Nmr, Tracecert(r)
213. Methylaminolevulinate Hydrochloride Impurity I [ep]
214. Benzoic Acid, European Pharmacopoeia (ep) Reference Standard
215. Mettler-toledo Calibration Substance Me 18555, Benzoic Acid
216. Benzoic Acid On Polystyrene, 1.6-2.1 Mmol/g@crlfmfcd03456189
217. Benzoic Acid, For Calorimetrical Determination (approx. 26460 J/g)
218. Benzoic Acid, United States Pharmacopeia (usp) Reference Standard
219. Ss Benzoic Acid, 2000 Mug/ml In Dichloromethane, Analytical Standard
220. Benzoic Acid Solution, 200 Mug/ml In Methylene Chloride, Analytical Standard
221. Benzoic Acid Solution, Certified Reference Material, 2000 Mug/ml In Methylene Chloride
222. Benzoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
223. Benzoic Acid, Puriss. P.a., Acs Reagent, Reag. Ph. Eur., >=99.9% (alkalimetric)
224. 14322-82-8
225. B A
226. Benzoic Acid, Certified Reference Material For Titrimetry, Certified By Bam According To Iso 17025, >=99.5%
227. Benzoic Acid, Meets Analytical Specification Of Ph. Eur., Bp, Usp, Fcc, E210, 99.5-100.5% (alkalimetric)
228. Carboxypolystyrene, 100-200 Mesh, Extent Of Labeling: 0.5-1.5 Mmol/g Loading, 1 % Cross-linked
229. Carboxypolystyrene, 100-200 Mesh, Extent Of Labeling: 1.6-3.0 Mmol/g Loading, 1 % Cross-linked
230. Mettler-toledo Calibration Substance Me 18555, Benzoic Acid, Analytical Standard, For The Calibration Of The Thermosystem 900, Traceable To Primary Standards (lgc)
231. Scavengepore(tm) Benzoic Acid, Macroporous, 40-70 Mesh, Extent Of Labeling: 0.5-1.5 Mmol Per G Loading
| Molecular Weight | 122.12 g/mol |
|---|---|
| Molecular Formula | C7H6O2 |
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 122.036779430 g/mol |
| Monoisotopic Mass | 122.036779430 g/mol |
| Topological Polar Surface Area | 37.3 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 104 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Antifungal Agents; Food Preservatives
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
Benzoic acid ... has a long history of use as an antifungal agent in topical therapeutic preparations such as Whitfield's ointment (benzoic acid 6% and salicylic acid 3%).
Rowe, R.C., Sheskey, P.J., Quinn, M.E.; (Eds.), Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, London, England 2009, p. 61
... It is used especially in the treatment of athlete's foot and to lesser extent for management of ringworm.
Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1172
Medication (vet): has been used with salicylic acid as topical antifungal
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 187
/Experimental Ther:/ Process for controlling waste nitrogen accumulation diseases in humans by administering at least 1 compound selected from group of benzoic acid, phenylacetic acid and their salts is disclosed. Sodium benzoate, (6.2 g/day) given to female patient with carbophosphate synthetase deficiency Increased total urinary nitrogen excretion 58%.
Brusilow SW et al; US Patent Number 4284647 08/18/81 (Johns Hopkins University)
The minimum lethal human oral dose of benzoic acid is 500 mg/kg body-weight.
Rowe, R.C., Sheskey, P.J., Quinn, M.E.; (Eds.), Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, London, England 2009, p. 62
Antifungal Agents
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)
Food Preservatives
Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods. (See all compounds classified as Food Preservatives.)
After oral ingestion of benzoic acid and sodium benzoate, there is a rapid absorption (of undissociated benzoic acid) from the gastrointestinal tract in experimental animals or humans. ... 100% absorption can be assumed. In humans, the peak plasma concentration is reached within 1-2 hr.
International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Number 26: Benzoic acid and Sodium Benzoate (2000). Available from, as of March 24, 2005: https://www.inchem.org/pages/cicads.html
Experiments on the distribution and elimination of (14)C-benzoate in the rat have shown no accumulation of sodium benzoate or benzoic acid in the body.
International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Number 26: Benzoic acid and Sodium Benzoate (2000). Available from, as of March 24, 2005: https://www.inchem.org/pages/cicads.html
Benzoic acid and sodium benzoate are rapidly absorbed from the gastrointestinal tract of mammals and conjugated with glycine in the liver. The resulting hippuric acid is excreted in the urine rapidly (75% to 100% of the dose is excreted within 6 hours; the remaining dose is excreted within 2 to 3 days).
Cosmetic Ingredient Review Expert Panel; International Journal of Toxicology 20 (suppl. 3): 23-50 (2001)
/Investigators/ reported that 42.6% +/-16.5% of a dermally applied (14)C-Benzoic acid dose (4 ug/sq cm; in acetone) was excreted in the urine within 24 hours. When applied in petrolatum, 60.5% of the dose was absorbed.
Cosmetic Ingredient Review Expert Panel; International Journal of Toxicology 20 (suppl. 3): 23-50 (2001)
For more Absorption, Distribution and Excretion (Complete) data for BENZOIC ACID (17 total), please visit the HSDB record page.
Benzoic acid ... conjugated with glycine to give hippuric acid in ... many mammals (man, monkeys, pig, rabbit, rodents, cat, dog, ferret & hedgehog). Dog, ferret, & hedgehog also excreted ... benzoyl glucuronide ... but indian fruit bat excreted almost all dose as benzoyl glucuronide.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 407
/Investigators/ demonstrated that biotransformation of benzoic acid to hippuric acid follows saturable or Michaelis-Menten kinetics in humans following ingestion of sodium benzoate. /Sodium Benzoate/
Cosmetic Ingredient Review Expert Panel; International Journal of Toxicology 20 (suppl. 3): 23-50 (2001)
The availability of glycine was the rate-limiting factor in the formation of hippuric acid. When insufficient glycine was available benzoyl glucuronide was formed.
Cosmetic Ingredient Review Expert Panel; International Journal of Toxicology 20 (suppl. 3): 23-50 (2001)
/Investigators/ reported that both lipoic acid and valproic acid reduced the clearance of benzoic acid in rats that had been "loaded" with glycine. Both acids reduced the availability of hepatic coenzyme A that is needed for the adenosine triphosphate (ATP)-dependent conjugation with glycine.
Cosmetic Ingredient Review Expert Panel; International Journal of Toxicology 20 (suppl. 3): 23-50 (2001)
For more Metabolism/Metabolites (Complete) data for BENZOIC ACID (11 total), please visit the HSDB record page.
Benzoic acid has known human metabolites that include Benzoyl glucuronide.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
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