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Chemistry

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Also known as: Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)
Molecular Formula
C35H58O6
Molecular Weight
574.8  g/mol
InChI Key
AOBORMOPSGHCAX-UHFFFAOYSA-N

Vitamin E TPGS API
Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.
1 2D Structure

Vitamin E TPGS API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
2.1.2 InChI
InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
2.1.3 InChI Key
AOBORMOPSGHCAX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
2.2 Synonyms
2.2.1 MeSH Synonyms

1. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

2. Alpha-d-tocopherol Poly(ethylene Glycol) 2000 Succinate

3. Alpha-tocopheryl Polyethylene Glycol Succinate

4. Mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) Succinate Polyethylene Glycol Monoester

5. Poly(oxy-1,2-ethanediyl), Alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-

6. Tocofersolan

7. Tocopherol Poly(ethylene Glycol) 2000 Succinate

8. Tocopherol Polyethylene Glycol Succinate

9. Tocophersolan, (2r-(2r*(4r*,8r*)))-isomer

10. Tocopheryl Poly(ethylene Glycol) 1000 Succinate

11. Tpgs

12. Tpgs 2k

13. Vitamin E-tpgs

14. Vitamine E Peg-1000-succinate

2.2.2 Depositor-Supplied Synonyms

1. Vitamin E Tpgs

2. Tpgs

3. Tocophersolan [usan]

4. Tocofersolan (inn)

5. 30999-06-5

6. Tocophersolan (usan)

7. 1-o-(2-hydroxyethyl) 4-o-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] Butanedioate

8. Tocofersolan [inn]

9. Poly(oxy-1,2-ethanediyl),a-[4-[[(2r)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-2h-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

10. Tocofersolano

11. Tocofersolanum

12. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

13. Tocofersolan, Inn

14. Tocophersolan, Usan

15. Alpha-tocopheryl Polyethylene Glycol Succinate

16. Alpha-tocopheryl Polyethylene Glycol 1000 Succinate

17. Schembl3139787

18. Aquasol E Tpgs Liquid 77iu/ml

19. Dtxsid50860035

20. Chebi:176233

21. Bcp11679

22. Akos015967005

23. Ft-0675259

24. Tocopheryl Polyethylene Glycol 1000 Succinate

25. D06174

26. Q172409

27. D-alpha-tocopheryl Poly(ethylene Glycol) 1000 Succinate

28. D-alpha-tocopheryl Poly(ethylene Glycol)1000 Succinate

29. 1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

30. 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

31. D08cvc;d-(c) Paragraph Sign-tocopherol Polyethylene Glycol 1000 Succinate; Tpgs; Vitamin E-tpgs

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 574.8 g/mol
Molecular Formula C35H58O6
XLogP39.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count20
Exact Mass574.42333957 g/mol
Monoisotopic Mass574.42333957 g/mol
Topological Polar Surface Area82.1 Ų
Heavy Atom Count41
Formal Charge0
Complexity768
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 30999-06-5 / Vitamin E TPGS API API manufacturers, exporters & distributors?

Vitamin E TPGS API manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vitamin E TPGS API API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Vitamin E TPGS API manufacturer or Vitamin E TPGS API supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vitamin E TPGS API manufacturer or Vitamin E TPGS API supplier.

API | Excipient name

Vitamin E TPGS API

Synonyms

Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)

Cas Number

30999-06-5

About Vitamin E TPGS API

Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.

Tocopheryl polyethylene glycol 1000 succinate Manufacturers

A Tocopheryl polyethylene glycol 1000 succinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tocopheryl polyethylene glycol 1000 succinate, including repackagers and relabelers. The FDA regulates Tocopheryl polyethylene glycol 1000 succinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tocopheryl polyethylene glycol 1000 succinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tocopheryl polyethylene glycol 1000 succinate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

Tocopheryl polyethylene glycol 1000 succinate Suppliers

A Tocopheryl polyethylene glycol 1000 succinate supplier is an individual or a company that provides Tocopheryl polyethylene glycol 1000 succinate active pharmaceutical ingredient (API) or Tocopheryl polyethylene glycol 1000 succinate finished formulations upon request. The Tocopheryl polyethylene glycol 1000 succinate suppliers may include Tocopheryl polyethylene glycol 1000 succinate API manufacturers, exporters, distributors and traders.

click here to find a list of Tocopheryl polyethylene glycol 1000 succinate suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

Tocopheryl polyethylene glycol 1000 succinate USDMF

A Tocopheryl polyethylene glycol 1000 succinate DMF (Drug Master File) is a document detailing the whole manufacturing process of Tocopheryl polyethylene glycol 1000 succinate active pharmaceutical ingredient (API) in detail. Different forms of Tocopheryl polyethylene glycol 1000 succinate DMFs exist exist since differing nations have different regulations, such as Tocopheryl polyethylene glycol 1000 succinate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tocopheryl polyethylene glycol 1000 succinate DMF submitted to regulatory agencies in the US is known as a USDMF. Tocopheryl polyethylene glycol 1000 succinate USDMF includes data on Tocopheryl polyethylene glycol 1000 succinate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tocopheryl polyethylene glycol 1000 succinate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tocopheryl polyethylene glycol 1000 succinate suppliers with USDMF on PharmaCompass.

Tocopheryl polyethylene glycol 1000 succinate GMP

Tocopheryl polyethylene glycol 1000 succinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tocopheryl polyethylene glycol 1000 succinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Tocopheryl polyethylene glycol 1000 succinate GMP manufacturer or Tocopheryl polyethylene glycol 1000 succinate GMP API supplier for your needs.

Tocopheryl polyethylene glycol 1000 succinate CoA

A Tocopheryl polyethylene glycol 1000 succinate CoA (Certificate of Analysis) is a formal document that attests to Tocopheryl polyethylene glycol 1000 succinate's compliance with Tocopheryl polyethylene glycol 1000 succinate specifications and serves as a tool for batch-level quality control.

Tocopheryl polyethylene glycol 1000 succinate CoA mostly includes findings from lab analyses of a specific batch. For each Tocopheryl polyethylene glycol 1000 succinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tocopheryl polyethylene glycol 1000 succinate may be tested according to a variety of international standards, such as European Pharmacopoeia (Tocopheryl polyethylene glycol 1000 succinate EP), Tocopheryl polyethylene glycol 1000 succinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tocopheryl polyethylene glycol 1000 succinate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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