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    Also known as: Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)
    Molecular Formula
    C35H58O6
    Molecular Weight
    574.8  g/mol
    InChI Key
    AOBORMOPSGHCAX-UHFFFAOYSA-N
    Vitamin E TPGS API
    Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.
    1 2D Structure

    Vitamin E TPGS API

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
    2.1.2 InChI
    InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
    2.1.3 InChI Key
    AOBORMOPSGHCAX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    2. Alpha-d-tocopherol Poly(ethylene Glycol) 2000 Succinate

    3. Alpha-tocopheryl Polyethylene Glycol Succinate

    4. Mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) Succinate Polyethylene Glycol Monoester

    5. Poly(oxy-1,2-ethanediyl), Alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-

    6. Tocofersolan

    7. Tocopherol Poly(ethylene Glycol) 2000 Succinate

    8. Tocopherol Polyethylene Glycol Succinate

    9. Tocophersolan, (2r-(2r*(4r*,8r*)))-isomer

    10. Tocopheryl Poly(ethylene Glycol) 1000 Succinate

    11. Tpgs

    12. Tpgs 2k

    13. Vitamin E-tpgs

    14. Vitamine E Peg-1000-succinate

    2.2.2 Depositor-Supplied Synonyms

    1. Vitamin E Tpgs

    2. Tpgs

    3. Tocophersolan [usan]

    4. Tocofersolan (inn)

    5. 30999-06-5

    6. Tocophersolan (usan)

    7. 1-o-(2-hydroxyethyl) 4-o-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] Butanedioate

    8. Tocofersolan [inn]

    9. Poly(oxy-1,2-ethanediyl),a-[4-[[(2r)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-2h-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

    10. Tocofersolano

    11. Tocofersolanum

    12. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    13. Tocofersolan, Inn

    14. Tocophersolan, Usan

    15. Alpha-tocopheryl Polyethylene Glycol Succinate

    16. Alpha-tocopheryl Polyethylene Glycol 1000 Succinate

    17. Schembl3139787

    18. Aquasol E Tpgs Liquid 77iu/ml

    19. Dtxsid50860035

    20. Chebi:176233

    21. Bcp11679

    22. Akos015967005

    23. Ft-0675259

    24. Tocopheryl Polyethylene Glycol 1000 Succinate

    25. D06174

    26. Q172409

    27. D-alpha-tocopheryl Poly(ethylene Glycol) 1000 Succinate

    28. D-alpha-tocopheryl Poly(ethylene Glycol)1000 Succinate

    29. 1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

    30. 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

    31. D08cvc;d-(c) Paragraph Sign-tocopherol Polyethylene Glycol 1000 Succinate; Tpgs; Vitamin E-tpgs

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 574.8 g/mol
    Molecular Formula C35H58O6
    XLogP39.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count20
    Exact Mass574.42333957 g/mol
    Monoisotopic Mass574.42333957 g/mol
    Topological Polar Surface Area82.1 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity768
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1

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ESTATE, ROAD NO. 6"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1628101800,"product":"VITAMIN E TPGS 1000 (PMC ISOCHEM\/TPGS 1000 (NF)) LOT N\/BATCHN:2101010063 - ITEM CODE - 318300","address":"IRIS- 1004, KESAR GARDEN, PLOT NO. 53, SECTOR-20, KHARGHAR,","city":"NAVI MUMBAI.","supplier":"PMC ISOCHEM","supplierCountry":"FRANCE","foreign_port":"PARIS - ORLY","customer":"V-ENSURE PHARMA TECHNOLOGIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"450","totalValueFC":"5448.5","currency":"EUR","unitRateINR":"40410","date":"05-Aug-2021","totalValueINR":"404100","totalValueInUsd":"5448.5","indian_port":"BOMBAY AIR","hs_no":"29362800","bill_no":"4940512","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - ORLY","supplierAddress":"","customerAddress":"IRIS- 1004, KESAR GARDEN, PLOT NO. 53, SECTOR-20, KHARGHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1631644200,"product":"VITAMIN E TPGS NF (NOT INTENDED FOR FOOD USE) - SVB ORDER NO. 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DOV0001517 DT. 05.02.2018","address":"ZENITH HOUSE.OPP RACE COURSE.,3RD FLR.K KHADYE MARG.MAHALAXMI","city":"MUMBAI,MAHARASHTRA","supplier":"CONNELL BROS. CO.LLC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"CONNELL BROS COMPANY (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"356.5","totalValueFC":"7257.2","currency":"USD","unitRateINR":"27022.7","date":"01-Nov-2021","totalValueINR":"540454","totalValueInUsd":"7257.2","indian_port":"BOMBAY AIR","hs_no":"29362800","bill_no":"6082376","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZENITH HOUSE.OPP RACE COURSE.,3RD FLR.K KHADYE MARG.MAHALAXMI"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1644863400,"product":"VITAMIN E TPGS NF (NOT INTENDED FOR FOOD USE)","address":"ZENITH HOUSE.OPP RACE COURSE.,3RD FLR.K KHADYE MARG.MAHALAXMI","city":"MUMBAI,MAHARASHTRA","supplier":"CONNELL BROS. 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    29-Jan-2021
    04-Mar-2025
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    ABOUT THIS PAGE

    Looking for 30999-06-5 / TPGS Vitamin E API API manufacturers, exporters & distributors?

    TPGS Vitamin E API manufacturers, exporters & distributors 1

    36

    PharmaCompass offers a list of TPGS Vitamin E API API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right TPGS Vitamin E API manufacturer or TPGS Vitamin E API supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred TPGS Vitamin E API manufacturer or TPGS Vitamin E API supplier.

    PharmaCompass also assists you with knowing the TPGS Vitamin E API API Price utilized in the formulation of products. TPGS Vitamin E API API Price is not always fixed or binding as the TPGS Vitamin E API Price is obtained through a variety of data sources. The TPGS Vitamin E API Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    TPGS Vitamin E API

    Synonyms

    Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)

    Cas Number

    30999-06-5

    About TPGS Vitamin E API

    Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.

    Tocophersolan API Manufacturers

    A Tocophersolan API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tocophersolan API, including repackagers and relabelers. The FDA regulates Tocophersolan API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tocophersolan API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Tocophersolan API manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Tocophersolan API Suppliers

    A Tocophersolan API supplier is an individual or a company that provides Tocophersolan API active pharmaceutical ingredient (API) or Tocophersolan API finished formulations upon request. The Tocophersolan API suppliers may include Tocophersolan API API manufacturers, exporters, distributors and traders.

    click here to find a list of Tocophersolan API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Tocophersolan API USDMF

    A Tocophersolan API DMF (Drug Master File) is a document detailing the whole manufacturing process of Tocophersolan API active pharmaceutical ingredient (API) in detail. Different forms of Tocophersolan API DMFs exist exist since differing nations have different regulations, such as Tocophersolan API USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Tocophersolan API DMF submitted to regulatory agencies in the US is known as a USDMF. Tocophersolan API USDMF includes data on Tocophersolan API's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tocophersolan API USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Tocophersolan API suppliers with USDMF on PharmaCompass.

    Tocophersolan API GMP

    Tocophersolan API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Tocophersolan API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tocophersolan API GMP manufacturer or Tocophersolan API GMP API supplier for your needs.

    Tocophersolan API CoA

    A Tocophersolan API CoA (Certificate of Analysis) is a formal document that attests to Tocophersolan API's compliance with Tocophersolan API specifications and serves as a tool for batch-level quality control.

    Tocophersolan API CoA mostly includes findings from lab analyses of a specific batch. For each Tocophersolan API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Tocophersolan API may be tested according to a variety of international standards, such as European Pharmacopoeia (Tocophersolan API EP), Tocophersolan API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tocophersolan API USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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