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Chemistry

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Also known as: 151272-78-5, D19v7048jk, Ep 24332, Ep-24332, Ac-d-nal-d-cpa-d-pal-ser-tyr-d-hci-leu-lys(ipr)-pro-d-ala-nh2, D-alaninamide, n-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-n6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-
Molecular Formula
C74H100ClN15O14
Molecular Weight
1459.1  g/mol
InChI Key
NOENHWMKHNSHGX-IAOPALDYSA-N
FDA UNII
D19V7048JK

Teverelix
Teverelix is a synthetic decapeptide and antagonist of the naturally occurring gonadotropin-releasing hormone (GnRH), with potential hormone production inhibitory and antineoplastic activities. Upon administration, teverelix directly competes with GnRH for receptor binding in the anterior pituitary gland, thereby inhibiting GnRH receptor signaling. This inhibits the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. In females, this prevents the production of estrogen by the ovaries and may relieve symptoms from sex-hormone dependent diseases.
1 2D Structure

Teverelix

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(carbamoylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C74H100ClN15O14/c1-43(2)35-57(66(96)84-56(19-10-11-32-79-44(3)4)73(103)90-34-14-20-63(90)72(102)81-45(5)64(76)94)85-65(95)55(18-9-12-33-80-74(77)104)83-68(98)59(38-48-24-29-54(93)30-25-48)88-71(101)62(42-91)89-70(100)61(40-50-15-13-31-78-41-50)87-69(99)60(37-47-22-27-53(75)28-23-47)86-67(97)58(82-46(6)92)39-49-21-26-51-16-7-8-17-52(51)36-49/h7-8,13,15-17,21-31,36,41,43-45,55-63,79,91,93H,9-12,14,18-20,32-35,37-40,42H2,1-6H3,(H2,76,94)(H,81,102)(H,82,92)(H,83,98)(H,84,96)(H,85,95)(H,86,97)(H,87,99)(H,88,101)(H,89,100)(H3,77,80,104)/t45-,55-,56+,57+,58-,59+,60-,61-,62+,63+/m1/s1
2.1.3 InChI Key
NOENHWMKHNSHGX-IAOPALDYSA-N
2.2 Other Identifiers
2.2.1 UNII
D19V7048JK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ep 24332

2. Ep-24332

2.3.2 Depositor-Supplied Synonyms

1. 151272-78-5

2. D19v7048jk

3. Ep 24332

4. Ep-24332

5. Ac-d-nal-d-cpa-d-pal-ser-tyr-d-hci-leu-lys(ipr)-pro-d-ala-nh2

6. D-alaninamide, N-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-n6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-

7. D-23234

8. Teverelixum

9. Refchem:188970

10. (2s)-1-((2s)-2-(((2s)-2-(((2r)-2-(((2s)-2-(((2s)-2-(((2r)-2-(((2r)-2-(((2r)-2-acetamido-3-naphthalen-2-ylpropanoyl)amino)-3-(4-chlorophenyl)propanoyl)amino)-3-pyridin-3-ylpropanoyl)amino)-3-hydroxypropanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)-6-(carbamoylamino)hexanoyl)amino)-4-methylpentanoyl)amino)-6-(propan-2-ylamino)hexanoyl)-n-((2r)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide

11. Teverelix [inn]

12. Unii-d19v7048jk

13. D 23234

14. Orb1699148

15. Dtxsid301033772

16. N-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-l-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-n6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-d-alaninamide

17. Akos040749635

18. Db05624

19. Hy-105173

20. Cs-0025196

21. Q27275967

22. N-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-n6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-d-alaninamide

23. N-acetyl-3-(2-naphthyl)-d-alanyl-p-chloro-d-phenylalanyl-3-(3-pyridyl)-d-alanyl-l-seryl-l-tyrosyl-n(sup 6)-carbamoyl-d-lysyl-l-leucyl-n(sup 6)-isopropyl-l-lysyl-l-prolyl-d-alaninamide

2.4 Create Date
2007-07-04
3 Chemical and Physical Properties
Molecular Weight 1459.1 g/mol
Molecular Formula C74H100ClN15O14
XLogP34.5
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count16
Rotatable Bond Count41
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area446
Heavy Atom Count104
Formal Charge0
Complexity2810
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in benign prostatic hyperplasia, endometriosis, and prostate cancer.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hormone Antagonists

Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.


5.2 Mechanism of Action

Teverelix is a GnRH (Gonadotropin releasing hormone) antagonist.


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Looking for 151272-78-5 / Teverelix API manufacturers, exporters & distributors?

Teverelix manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Teverelix API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Teverelix manufacturer or Teverelix supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Teverelix manufacturer or Teverelix supplier.

API | Excipient name

Teverelix

Synonyms

151272-78-5, D19v7048jk, Ep 24332, Ep-24332, Ac-d-nal-d-cpa-d-pal-ser-tyr-d-hci-leu-lys(ipr)-pro-d-ala-nh2, D-alaninamide, n-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-n6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-

Cas Number

151272-78-5

Unique Ingredient Identifier (UNII)

D19V7048JK

About Teverelix

Teverelix is a synthetic decapeptide and antagonist of the naturally occurring gonadotropin-releasing hormone (GnRH), with potential hormone production inhibitory and antineoplastic activities. Upon administration, teverelix directly competes with GnRH for receptor binding in the anterior pituitary gland, thereby inhibiting GnRH receptor signaling. This inhibits the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. In females, this prevents the production of estrogen by the ovaries and may relieve symptoms from sex-hormone dependent diseases.

Teverelix Manufacturers

A Teverelix manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Teverelix, including repackagers and relabelers. The FDA regulates Teverelix manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Teverelix API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Teverelix Suppliers

A Teverelix supplier is an individual or a company that provides Teverelix active pharmaceutical ingredient (API) or Teverelix finished formulations upon request. The Teverelix suppliers may include Teverelix API manufacturers, exporters, distributors and traders.

Teverelix GMP

Teverelix Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Teverelix GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Teverelix GMP manufacturer or Teverelix GMP API supplier for your needs.

Teverelix CoA

A Teverelix CoA (Certificate of Analysis) is a formal document that attests to Teverelix's compliance with Teverelix specifications and serves as a tool for batch-level quality control.

Teverelix CoA mostly includes findings from lab analyses of a specific batch. For each Teverelix CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Teverelix may be tested according to a variety of international standards, such as European Pharmacopoeia (Teverelix EP), Teverelix JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Teverelix USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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