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Terevalefim

Terevalefim

Synopsis, Chemistry

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Also known as: Terevalefim, Ang-3777, Terevalefim [inn], Terevalefim [usan], Snv-003, Gg91uxk2m5

Molecular Formula

C₉H₈N₂S

Molecular Weight

176.24 g/mol

InChI Key

FOHWAQGURRYJFK-ONEGZZNKSA-N

FDA UNII

GG91UXK2M5

Terevalefim is under investigation in clinical trial NCT02474667 (Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney).

1 2D Structure

Terevalefim

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole

2.1.2 InChI

InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+

2.1.3 InChI Key

FOHWAQGURRYJFK-ONEGZZNKSA-N

2.1.4 Canonical SMILES

C1=CSC(=C1)C=CC2=CC=NN2

2.1.5 Isomeric SMILES

C1=CSC(=C1)/C=C/C2=CC=NN2

2.2 Other Identifiers

2.2.1 UNII

GG91UXK2M5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ang-3777

2. Snv-003

3. Terevalefim

2.3.2 Depositor-Supplied Synonyms

1. Terevalefim

2. Ang-3777

3. Terevalefim [inn]

4. Terevalefim [usan]

5. Snv-003

6. Gg91uxk2m5

7. 1070881-42-3

8. 500128-99-4

9. 5-((e)-2-thiophen-2-yl-vinyl)-lh-pyrazole

10. 1h-pyrazole, 3-((1e)-2-(2-thienyl)ethenyl)-

11. Bb3

12. Unii-gg91uxk2m5

13. 5-[(e)-2-thiophen-2-ylethenyl]-1h-pyrazole

14. Terevalefim [who-dd]

15. Bb-3

16. Schembl1225335

17. Chembl4650326

18. Schembl10149623

19. Gtpl11997

20. Ang3777

21. Zinc4301780

22. Who 11458

23. 3-[2-(2-thienyl)ethenyl]-1h-pyrazole

24. Hy-137455

25. Cs-0138662

26. (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole

27. E80357

28. (e)-3-(2-(thiophen-2-yl)vinyl)-1h-pyrazole

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₉H₈N₂S
Molecular Weight	176.24 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	176.04081944 g/mol
Monoisotopic Mass	176.04081944 g/mol
Topological Polar Surface Area	56.9 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	170
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Mechanism of Action

Terevalefim, a small molecule developed by Angion Biomedica Corp., mimics the activity of hepatocyte growth factor (HGF). Through its actions, it activates the c-Met cascade, exhibits c-Met dependence and c-Met receptor activation. As it is able to activate repair pathways, it has been tested in clinical trials for acute kidney injury and in delayed graft function. As of July 2020, Angion has announced a Phase 2 proof-of-concept trial to invesigate terevalefim on preventing and mitigating lung injury in patients with COVID-19 (NCT04459676).