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    Chemistry

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    Also known as: Onilcamotide [inn], Unii-uqe6kp7t0d, Uqe6kp7t0d, Rhoc peptide vaccine rv001v, Rv001, Rv-001
    Molecular Formula
    C96H177N39O24S
    Molecular Weight
    2293.7  g/mol
    InChI Key
    BSLDVUIBJUKAAR-GXARRZNISA-N
    RV001
    Onilcamotide is a cancer vaccine composed of an immunogenic peptide derived from the Ras homolog family member C (RhoC; Rho-related GTP-binding protein RhoC) that is emulsified in the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, onilcamotide may stimulate the host immune system to mount a humoral and cytotoxic T-lymphocyte (CTL) response against tumor cells expressing RhoC, which results in tumor cell lysis. RhoC, a tumor-associated antigen (TAA) that is overexpressed in a variety of tumor cell types, is associated with increased metastatic potential.
    1 2D Structure

    RV001

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
    2.1.2 InChI
    InChI=1S/C96H177N39O24S/c1-12-50(8)72(88(155)131-64(91(158)159)42-48(4)5)133-86(153)66-30-22-40-135(66)90(157)65(46-160)121-70(140)45-118-76(143)54(25-17-35-112-92(102)103)122-79(146)58(27-19-37-114-94(106)107)125-80(147)59(28-20-38-115-95(108)109)124-78(145)55(23-13-15-33-97)126-85(152)63(43-68(101)138)130-82(149)56(24-14-16-34-98)123-81(148)60(29-21-39-116-96(110)111)128-87(154)71(49(6)7)132-83(150)61(31-32-67(100)137)127-84(151)62(41-47(2)3)120-69(139)44-117-75(142)52(10)119-77(144)57(26-18-36-113-93(104)105)129-89(156)73(53(11)136)134-74(141)51(9)99/h47-66,71-73,136,160H,12-46,97-99H2,1-11H3,(H2,100,137)(H2,101,138)(H,117,142)(H,118,143)(H,119,144)(H,120,139)(H,121,140)(H,122,146)(H,123,148)(H,124,145)(H,125,147)(H,126,152)(H,127,151)(H,128,154)(H,129,156)(H,130,149)(H,131,155)(H,132,150)(H,133,153)(H,134,141)(H,158,159)(H4,102,103,112)(H4,104,105,113)(H4,106,107,114)(H4,108,109,115)(H4,110,111,116)/t50-,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,71-,72-,73-/m0/s1
    2.1.3 InChI Key
    BSLDVUIBJUKAAR-GXARRZNISA-N
    2.1.4 Canonical SMILES
    CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C1CCCN1C(=O)C(CS)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)O)NC(=O)C(C)N
    2.1.5 Isomeric SMILES
    CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. R 1507

    2. R-1507

    3. R-1507 Monoclonal Antibody

    4. R1507

    5. Ro-4858696

    6. Ro-4858696-000

    7. Ro-4858696000

    8. Ro4858696

    9. Ro4858696-000

    10. Rv-001

    11. Rv001

    12. Tepezza

    13. Teprotumumab

    14. Teprotumumab-trbw

    2.2.2 Depositor-Supplied Synonyms

    1. Onilcamotide [inn]

    2. Unii-uqe6kp7t0d

    3. Uqe6kp7t0d

    4. Rhoc Peptide Vaccine Rv001v

    5. Rv001

    6. Rv-001

    7. Ala-thr-arg-ala-gly-leu-gln-val-arg-lys-asn-lys-arg-arg-arg-gly-cys-pro-ile-leu

    8. 1164096-85-8

    9. L-alanyl-l-threonyl-l-arginyl-l-alanylglycyl-l-leucyl-l-glutaminyl-l-valyl-l-arginyl-l-lysyl-l-asparaginyl-l-lysyl-l-arginyl-l-arginyl-l-arginylglycyl-l-cysteinyl-l-prolyl-l-isoleucyl-l-leucine

    10. L-leucine, L-alanyl-l-threonyl-l-arginyl-l-alanylglycyl-l-leucyl-l-glutaminyl-l-valyl-l-arginyl-l-lysyl-l-asparaginyl-l-lysyl-l-arginyl-l-arginyl-l-arginylglycyl-l-cysteinyl-l-prolyl-l-isoleucyl-

    2.3 Create Date
    2021-02-25
    3 Chemical and Physical Properties
    Molecular Weight 2293.7 g/mol
    Molecular Formula C96H177N39O24S
    XLogP3-11.3
    Hydrogen Bond Donor Count41
    Hydrogen Bond Acceptor Count33
    Rotatable Bond Count85
    Exact Mass2293.3582937 g/mol
    Monoisotopic Mass2292.3549388 g/mol
    Topological Polar Surface Area1080 Ų
    Heavy Atom Count160
    Formal Charge0
    Complexity4890
    Isotope Atom Count0
    Defined Atom Stereocenter Count20
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1

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    ABOUT THIS PAGE

    Looking for 1164096-85-8 / RV001 API manufacturers, exporters & distributors?

    RV001 manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of RV001 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right RV001 manufacturer or RV001 supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred RV001 manufacturer or RV001 supplier.

    PharmaCompass also assists you with knowing the RV001 API Price utilized in the formulation of products. RV001 API Price is not always fixed or binding as the RV001 Price is obtained through a variety of data sources. The RV001 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    RV001

    Synonyms

    Onilcamotide [inn], Unii-uqe6kp7t0d, Uqe6kp7t0d, Rhoc peptide vaccine rv001v, Rv-001, Ala-thr-arg-ala-gly-leu-gln-val-arg-lys-asn-lys-arg-arg-arg-gly-cys-pro-ile-leu

    Cas Number

    1164096-85-8

    About RV001

    Onilcamotide is a cancer vaccine composed of an immunogenic peptide derived from the Ras homolog family member C (RhoC; Rho-related GTP-binding protein RhoC) that is emulsified in the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, onilcamotide may stimulate the host immune system to mount a humoral and cytotoxic T-lymphocyte (CTL) response against tumor cells expressing RhoC, which results in tumor cell lysis. RhoC, a tumor-associated antigen (TAA) that is overexpressed in a variety of tumor cell types, is associated with increased metastatic potential.

    teprotumumab-trbw Manufacturers

    A teprotumumab-trbw manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of teprotumumab-trbw, including repackagers and relabelers. The FDA regulates teprotumumab-trbw manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. teprotumumab-trbw API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    teprotumumab-trbw Suppliers

    A teprotumumab-trbw supplier is an individual or a company that provides teprotumumab-trbw active pharmaceutical ingredient (API) or teprotumumab-trbw finished formulations upon request. The teprotumumab-trbw suppliers may include teprotumumab-trbw API manufacturers, exporters, distributors and traders.

    teprotumumab-trbw GMP

    teprotumumab-trbw Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of teprotumumab-trbw GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right teprotumumab-trbw GMP manufacturer or teprotumumab-trbw GMP API supplier for your needs.

    teprotumumab-trbw CoA

    A teprotumumab-trbw CoA (Certificate of Analysis) is a formal document that attests to teprotumumab-trbw's compliance with teprotumumab-trbw specifications and serves as a tool for batch-level quality control.

    teprotumumab-trbw CoA mostly includes findings from lab analyses of a specific batch. For each teprotumumab-trbw CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    teprotumumab-trbw may be tested according to a variety of international standards, such as European Pharmacopoeia (teprotumumab-trbw EP), teprotumumab-trbw JP (Japanese Pharmacopeia) and the US Pharmacopoeia (teprotumumab-trbw USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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