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TECHNETIUM TC-99M MEDRONATE

Synopsis, Chemistry

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Also known as: 80908-09-4, Phosphonomethylphosphonic acid;technetium-99, Technetium tc 99m medronate (usp), Technetium tc-99m medronate anhydrous, 8v3fgc4j77, Technetium (99mtc) medronic acid

Molecular Formula

CH₆O₆P₂Tc

Molecular Weight

274.91 g/mol

InChI Key

IGLHHEWLHQOTJM-IEOVAKBOSA-N

A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.

1 2D Structure

TECHNETIUM TC-99M MEDRONATE

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

phosphonomethylphosphonic acid;technetium-99

2.1.2 InChI

InChI=1S/CH6O6P2.Tc/c2-8(3,4)1-9(5,6)7;/h1H2,(H2,2,3,4)(H2,5,6,7);/i;1+1

2.1.3 InChI Key

IGLHHEWLHQOTJM-IEOVAKBOSA-N

2.1.4 Canonical SMILES

C(P(=O)(O)O)P(=O)(O)O.[Tc]

2.1.5 Isomeric SMILES

C(P(=O)(O)O)P(=O)(O)O.[99Tc]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 99mtc Methylene Diphosphonate

2. 99mtc-mdp

3. 99mtc-methylene Diphosphonate

4. Diphosphonate, 99mtc-methylene

5. Diphosphonate, Tc-99m Methylene

6. Diphosphonate, Technetium Methylene

7. Medronate, Tc-99

8. Methylene Diphosphonate, Tc-99m

9. Methylene Diphosphonate, Technetium

10. Tc 99 Medronate

11. Tc 99m Methylene Diphosphonate

12. Tc-99 Medronate

13. Tc-99m Methylene Diphosphonate

14. Technetium Methylene Diphosphonate

15. Technetium Tc 99m Medronate

16. Technetium Tc 99m Methylenediphosphonate

2.2.2 Depositor-Supplied Synonyms

1. 80908-09-4

2. Phosphonomethylphosphonic Acid;technetium-99

3. Technetium Tc 99m Medronate (usp)

4. Technetium Tc-99m Medronate Anhydrous

5. 8v3fgc4j77

6. Technetium (99mtc) Medronic Acid

7. Technetium (99mtc) Methylenediphosphonate

8. Technetium-99 Medronate

9. Technetium-99mtc-hydroxymethylene Diphosphonate

10. An-mdp (tn)

11. Unii-8v3fgc4j77

12. 63347-66-0

13. Phosphonic Acid, Methylenebis-, Technetium-99tc Salt

14. Chebi:32186

15. Moli000842

16. Nsc749127

17. Nsc-749127

18. D02029

19. Q7692228

20. Radiolabeled Technetium Tc 99m Medronate (99mtc-mdp)

2.3 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	CH₆O₆P₂Tc
Molecular Weight	274.91 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	274.870212 g/mol
Monoisotopic Mass	274.870212 g/mol
Topological Polar Surface Area	115 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	152
Isotope Atom Count	1
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Radiopharmaceuticals

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)

4.2 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09B - Skeleton

V09BA - Technetium (99mtc) compounds

V09BA02 - Technetium (99mTc) medronic acid