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Chemistry

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Also known as: 53-60-1, Promazine hcl, Sparine, Starazin, Talofen, Promazine (hydrochloride)
Molecular Formula
C17H21ClN2S
Molecular Weight
320.9  g/mol
InChI Key
JIVSXRLRGOICGA-UHFFFAOYSA-N
FDA UNII
U16EOR79U4

Promazine
A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
1 2D Structure

Promazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
2.1.3 InChI Key
JIVSXRLRGOICGA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
2.2 Other Identifiers
2.2.1 UNII
U16EOR79U4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hydrochloride, Promazine

2. Promazine

3. Protactyl

4. Sinophenin

5. Sparine

2.3.2 Depositor-Supplied Synonyms

1. 53-60-1

2. Promazine Hcl

3. Sparine

4. Starazin

5. Talofen

6. Promazine (hydrochloride)

7. Promazine Monohydrochloride

8. Rp 4560

9. N,n-dimethyl-3-(10h-phenothiazin-10-yl)propan-1-amine Hydrochloride

10. Nsc-17468

11. Promazinehydrochloride

12. Promazine Hydrochloride [usp]

13. Mls000069671

14. U16eor79u4

15. 10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride

16. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

17. N-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

18. 10-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

19. Smr000058499

20. Dsstox_cid_26949

21. Dsstox_rid_82026

22. Dsstox_gsid_46949

23. 10-(gamma-dimethylamino-n-propyl)phenothiazine Hydrochloride

24. Promazine Hydrochloride (usp)

25. Chebi:8460

26. N,n-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride

27. Chlorowodorek Promazyny

28. Chlorowodorek Promazyny [polish]

29. Cas-53-60-1

30. Sr-01000000228

31. Ncgc00015829-02

32. Einecs 200-179-7

33. Nsc 17468

34. N-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

35. 10-(3-[dimethylamino]propyl)phenothiazine Hydrochloride

36. 10-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

37. Unii-u16eor79u4

38. Esparinal

39. Verofen

40. Ai3-28022

41. Sr-01000000228-4

42. Promazine Chloride

43. Promazine-d6 Hcl

44. Prestwick_974

45. Sparine (tn)

46. Romtiazin Hydrochloride

47. Opera_id_41

48. Sinophenin Hydrochloride

49. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Hydrochloride

50. Propazin (pharmaceutical)

51. Regid_for_cid_5887

52. Mls001148436

53. Mls002222285

54. Schembl123418

55. Spectrum1500509

56. 10-(3-dimethylaminopropyl)phenothiazine Hydrochloride

57. Chembl1200469

58. Dtxsid4046949

59. Hms1570k07

60. Hms1920l14

61. Pharmakon1600-01500509

62. Hy-b1225

63. Nsc17468

64. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Monohydrochloride

65. Promazine Hydrochloride [mi]

66. Tox21_110235

67. Tox21_500961

68. 10-h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

69. Ccg-40284

70. Nsc757300

71. S5428

72. Akos015964305

73. Tox21_110235_1

74. Cs-4873

75. Ks-1384

76. Lp00961

77. Nsc-757300

78. Promazine Hydrochloride [mart.]

79. Promazine Hydrochloride [vandf]

80. Promazine Hydrochloride [usp-rs]

81. Promazine Hydrochloride [who-dd]

82. Ncgc00015829-12

83. Ncgc00094262-01

84. Ncgc00094262-02

85. Ncgc00094262-03

86. Ncgc00094262-04

87. Ncgc00094262-05

88. Ncgc00261646-01

89. Ac-18101

90. Promazine Hydrochloride [green Book]

91. Eu-0100961

92. Ft-0674047

93. Promazine Hydrochloride [orange Book]

94. Promazine Hydrochloride [ep Monograph]

95. Wln: T C666 Bn Isj B3n1&1 &gh

96. D00797

97. D78322

98. P 6656

99. Promazine Hydrochloride [usp Monograph]

100. Sr-01000000228-2

101. Sr-01000000228-8

102. W-105721

103. Q27108085

104. Z2784093694

105. Promazine Hydrochloride, Vetranal(tm), Analytical Standard

106. 10-(.gamma.-dimethylamino-n-propyl)phenothiazine Hydrochloride

107. Dimethyl[3-(10h-phenothiazin-10-yl)propyl]amine Hydrochloride

108. Promazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

109. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Hydrochloride (1:1)

110. N,n-dimethyl-3-(10h-phenothiazin-10-yl)-1-propanamine Hydrochloride

111. Promazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

112. Promazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 320.9 g/mol
Molecular Formula C17H21ClN2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.1113975 g/mol
Monoisotopic Mass320.1113975 g/mol
Topological Polar Surface Area31.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


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10-Apr-2025
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ABOUT THIS PAGE

Looking for 53-60-1 / Promazine API manufacturers, exporters & distributors?

Promazine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Promazine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Promazine manufacturer or Promazine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Promazine manufacturer or Promazine supplier.

PharmaCompass also assists you with knowing the Promazine API Price utilized in the formulation of products. Promazine API Price is not always fixed or binding as the Promazine Price is obtained through a variety of data sources. The Promazine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Promazine

Synonyms

53-60-1, Promazine hcl, Sparine, Starazin, Talofen, Promazine (hydrochloride)

Cas Number

53-60-1

Unique Ingredient Identifier (UNII)

U16EOR79U4

About Promazine

A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Talofen Manufacturers

A Talofen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Talofen, including repackagers and relabelers. The FDA regulates Talofen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Talofen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Talofen manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Talofen Suppliers

A Talofen supplier is an individual or a company that provides Talofen active pharmaceutical ingredient (API) or Talofen finished formulations upon request. The Talofen suppliers may include Talofen API manufacturers, exporters, distributors and traders.

click here to find a list of Talofen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Talofen USDMF

A Talofen DMF (Drug Master File) is a document detailing the whole manufacturing process of Talofen active pharmaceutical ingredient (API) in detail. Different forms of Talofen DMFs exist exist since differing nations have different regulations, such as Talofen USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Talofen DMF submitted to regulatory agencies in the US is known as a USDMF. Talofen USDMF includes data on Talofen's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Talofen USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Talofen suppliers with USDMF on PharmaCompass.

Talofen CEP

A Talofen CEP of the European Pharmacopoeia monograph is often referred to as a Talofen Certificate of Suitability (COS). The purpose of a Talofen CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Talofen EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Talofen to their clients by showing that a Talofen CEP has been issued for it. The manufacturer submits a Talofen CEP (COS) as part of the market authorization procedure, and it takes on the role of a Talofen CEP holder for the record. Additionally, the data presented in the Talofen CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Talofen DMF.

A Talofen CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Talofen CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Talofen suppliers with CEP (COS) on PharmaCompass.

Talofen GMP

Talofen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Talofen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Talofen GMP manufacturer or Talofen GMP API supplier for your needs.

Talofen CoA

A Talofen CoA (Certificate of Analysis) is a formal document that attests to Talofen's compliance with Talofen specifications and serves as a tool for batch-level quality control.

Talofen CoA mostly includes findings from lab analyses of a specific batch. For each Talofen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Talofen may be tested according to a variety of international standards, such as European Pharmacopoeia (Talofen EP), Talofen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Talofen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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