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Sulforidazine

Sulforidazine

Synopsis, Chemistry

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Also known as: Imagotan, Psychoson, Inofal, 14759-06-9, Thioridazine 2-sulfone, Thioridazine-2-sulfone

Molecular Formula

C₂₁H₂₆N₂O₂S₂

Molecular Weight

402.6 g/mol

InChI Key

FLGCRGJDQJIJAW-UHFFFAOYSA-N

FDA UNII

B7599I244X

sulforidazine is a natural product found in Aspergillus fumigatus with data available.

1 2D Structure

Sulforidazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine

2.1.2 InChI

InChI=1S/C21H26N2O2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)26-21-11-10-17(15-19(21)23)27(2,24)25/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

2.1.3 InChI Key

FLGCRGJDQJIJAW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)C

2.2 Other Identifiers

2.2.1 UNII

B7599I244X

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Imagotan

2. Psychoson

3. Inofal

4. 14759-06-9

5. Thioridazine 2-sulfone

6. Thioridazine-2-sulfone

7. Tpn-12

8. Thioridazine Sulfone

9. Thioridazine Sulphone

10. 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfonylphenothiazine

11. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine

12. 10h-phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-

13. B7599i244x

14. Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfonyl-

15. Solforidazina [dcit]

16. Solforidazina

17. Sulforidazina

18. Sulforidazinum

19. Tpn 12

20. Sulforidazine [inn:dcf]

21. 10h-phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfonyl)-

22. Sulforidazinum [inn-latin]

23. Sulforidazina [inn-spanish]

24. Einecs 238-818-7

25. Brn 1230366

26. 2-methylsulfonyl-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine

27. (+/-)-thioridazine-2-sulfone

28. 2-methylsulfonyl-10-(2-(1-methyl-2-piperidyl)ethyl)phenothiazine

29. Unii-b7599i244x

30. 2-methylsulfonyl-10-(2-(1-methyl-2-piperidyl)ethyl)phenothiazin

31. Sulforidazine [mi]

32. Sulforidazine [inn]

33. Schembl145025

34. Sulforidazine [mart.]

35. Sulforidazine [who-dd]

36. Chembl2107268

37. Bdbm86723

38. Dtxsid30864531

39. Chebi:135644

40. Nsc_31765

41. Akos030239787

42. Cas_14759-06-9

43. Ft-0675190

44. Thioridazine Impurity E [ep Impurity]

45. L000789

46. J-008369

47. Q7636215

48. Thioridazine Hydrochloride Impurity E [ep Impurity]

49. 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-methylsulfonylphenothiazine

50. 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfonyl)-10h-phenothiazine

51. 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-10h-phenothiazine #

52. 2-methanesulfonyl-10-[2-(1-methylpiperidin-2-yl)ethyl]-10h-phenothiazine

53. Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylsulfonyl)-

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₆N₂O₂S₂
Molecular Weight	402.6 g/mol
XLogP3	4.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	402.14357042 g/mol
Monoisotopic Mass	402.14357042 g/mol
Topological Polar Surface Area	74.3 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	606
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)