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Chemistry

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Also known as: Cct245737, 1489389-18-5, Cct-245737, Qb6lnl4nf6, Sra737, Sra-737 [who-sdg]
Molecular Formula
C16H16F3N7O
Molecular Weight
379.34  g/mol
InChI Key
YBYYWUUUGCNAHQ-LLVKDONJSA-N
FDA UNII
QB6LNL4NF6

SRA737
Chk1 Inhibitor SRA737 is an orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor SRA737 selectively binds to chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. SRA737 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an adenosine triphosphate (ATP)-dependent serine/threonine kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic agents by repairing DNA damage.
1 2D Structure

SRA737

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile
2.1.2 InChI
InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1
2.1.3 InChI Key
YBYYWUUUGCNAHQ-LLVKDONJSA-N
2.1.4 Canonical SMILES
C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N
2.1.5 Isomeric SMILES
C1CO[C@H](CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N
2.2 Other Identifiers
2.2.1 UNII
QB6LNL4NF6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

2. Cct245737

2.3.2 Depositor-Supplied Synonyms

1. Cct245737

2. 1489389-18-5

3. Cct-245737

4. Qb6lnl4nf6

5. Sra737

6. Sra-737 [who-sdg]

7. Pnt-737

8. Sra-737

9. 2-pyrazinecarbonitrile, 5-((4-(((2r)-2-morpholinylmethyl)amino)-5-(trifluoromethyl)-2-pyridinyl)amino)-

10. Unii-qb6lnl4nf6

11. Gtpl9187

12. Chembl4169078

13. Schembl15392098

14. Us9663503, Compound 1

15. Bdbm328993

16. Sra737; Pnt-737

17. Ex-a1607

18. Mfcd30489721

19. Nsc793726

20. Zinc205442186

21. Ccg-268393

22. Compound 4 [pmid: 27167172]

23. Cs-5863

24. Nsc-793726

25. Cct-245737?

26. Ac-36122

27. Bs-15458

28. Hy-18958

29. J3.603.159j

30. Q27075794

31. (r)5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

32. (r)a?-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

33. 5-[(4-{[(2r)-morpholin-2-ylmethyl]amino}-5-(trifluoromethyl)pyridin-2-yl)amino]pyrazine-2-carbonitrile

34. 5-[[4-[[(2r)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile

35. 5-[[4-[[(2r)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

2.4 Create Date
2013-12-02
3 Chemical and Physical Properties
Molecular Weight 379.34 g/mol
Molecular Formula C16H16F3N7O
XLogP31.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Exact Mass379.13684265 g/mol
Monoisotopic Mass379.13684265 g/mol
Topological Polar Surface Area108 Ų
Heavy Atom Count27
Formal Charge0
Complexity526
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1489389-18-5 / SRA737 API manufacturers, exporters & distributors?

SRA737 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of SRA737 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right SRA737 manufacturer or SRA737 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred SRA737 manufacturer or SRA737 supplier.

PharmaCompass also assists you with knowing the SRA737 API Price utilized in the formulation of products. SRA737 API Price is not always fixed or binding as the SRA737 Price is obtained through a variety of data sources. The SRA737 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

SRA737

Synonyms

Cct245737, 1489389-18-5, Cct-245737, Qb6lnl4nf6, Sra-737 [who-sdg], Pnt-737

Cas Number

1489389-18-5

Unique Ingredient Identifier (UNII)

QB6LNL4NF6

About SRA737

Chk1 Inhibitor SRA737 is an orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor SRA737 selectively binds to chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. SRA737 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an adenosine triphosphate (ATP)-dependent serine/threonine kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic agents by repairing DNA damage.

SRA737 Manufacturers

A SRA737 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of SRA737, including repackagers and relabelers. The FDA regulates SRA737 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. SRA737 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

SRA737 Suppliers

A SRA737 supplier is an individual or a company that provides SRA737 active pharmaceutical ingredient (API) or SRA737 finished formulations upon request. The SRA737 suppliers may include SRA737 API manufacturers, exporters, distributors and traders.

SRA737 GMP

SRA737 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of SRA737 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right SRA737 GMP manufacturer or SRA737 GMP API supplier for your needs.

SRA737 CoA

A SRA737 CoA (Certificate of Analysis) is a formal document that attests to SRA737's compliance with SRA737 specifications and serves as a tool for batch-level quality control.

SRA737 CoA mostly includes findings from lab analyses of a specific batch. For each SRA737 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

SRA737 may be tested according to a variety of international standards, such as European Pharmacopoeia (SRA737 EP), SRA737 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (SRA737 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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