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SODIUM FLUORIDE F 18
Also known as: Sodium fluoride f 18, Sodium fluoride-18f, 22554-99-0, Sodium fluoride (na18f), Fluorine f 18 sodium fluoride, Sodium;fluorine-18(1-)
Molecular Formula
FNa
Molecular Weight
40.990707  g/mol
InChI Key
PUZPDOWCWNUUKD-ULWFUOSBSA-M
FDA UNII
9L75099X6R

Sodium Fluoride F-18 is a radiopharmaceutical consisting of the sodium salt of fluorine F 18 fluoride with radioisotopic and bone mineralizing activities. Fluoride binds to calcium ions in hydroxyapatite crystals in bone. The uptake and incorporation of positron-emitting fluorine F 18 fluoride into bone can be imaged using positron emission tomography (PET) or single-photon emission computed tomography (SPECT), allowing visualization of malignant bone lesions in which regional blood flow and bone turnover are increased.
1 2D Structure

SODIUM FLUORIDE F 18

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;fluorine-18(1-)
2.1.2 InChI
InChI=1S/FH.Na/h1H;/q;+1/p-1/i1-1;
2.1.3 InChI Key
PUZPDOWCWNUUKD-ULWFUOSBSA-M
2.1.4 Canonical SMILES
[F-].[Na+]
2.1.5 Isomeric SMILES
[18F-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
9L75099X6R
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sodium Fluoride F 18

2. Sodium Fluoride-18f

3. 22554-99-0

4. Sodium Fluoride (na18f)

5. Fluorine F 18 Sodium Fluoride

6. Sodium;fluorine-18(1-)

7. Sodium Radiofluoride

8. Sodium Fluoride, F-18

9. Sodium Fluoride (18f)

10. Sodium Fluoride F 18 [usp]

11. 9l75099x6r

12. Sodium Fluoride F 18 (usp)

13. Sodium 18f-fluoride

14. Sodium Fluoride (f18)

15. 18f-naf

16. F-18 Naf

17. Unii-9l75099x6r

18. Fluorine 18-labeled Sodium Fluoride

19. Fluorine, F-18

20. Fluorine F-18 (tn)

21. Chembl1200744

22. Dtxsid001027605

23. Nsc749126

24. Nsc-749126

25. Sodium Fluoride (18f) [who-dd]

26. Sodium Fluoride F 18 [usp Impurity]

27. Sodium Fluoride F-18 [orange Book]

28. D05860

29. Q27272701

30. Radiolabeled Fluorine-18 Sodium Fluoride (18f-naf)

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 40.990707 g/mol
Molecular Formula FNa
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass40.990707 g/mol
Monoisotopic Mass40.990707 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count2
Formal Charge0
Complexity2
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 FDA Pharmacological Classification
4.1.1 Pharmacological Classes
Radiopharmaceutical Activity [MoA]; Radioactive Diagnostic Agent [EPC]
4.2 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09I - Tumour detection

V09IX - Other diagnostic radiopharmaceuticals for tumour detection

V09IX06 - Sodium fluoride (18F)


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