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Sodium Alginate

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Also known as: Sodium alginate, 9005-38-3, Natriumglucuronat, Schembl20919851, Ft-0621962, Ft-0670280

Molecular Formula

C₆H₉NaO₇

Molecular Weight

216.12 g/mol

InChI Key

MSXHSNHNTORCAW-UHFFFAOYSA-M

Salts and esters of ALGINIC ACID that are used as HYDROGELS; DENTAL IMPRESSION MATERIALS, and as absorbent materials for surgical dressings (BANDAGES, HYDROCOLLOID). They are also used to manufacture MICROSPHERES and NANOPARTICLES for DIAGNOSTIC REAGENT KITS and DRUG DELIVERY SYSTEMS.

1 2D Structure

Sodium Alginate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate

2.1.2 InChI

InChI=1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1

2.1.3 InChI Key

MSXHSNHNTORCAW-UHFFFAOYSA-M

2.1.4 Canonical SMILES

C1(C(C(OC(C1O)O)C(=O)[O-])O)O.[Na+]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Alginate

2. Alginate, Barium

3. Alginate, Calcium

4. Alginate, Copper

5. Alginate, Potassium

6. Alginate, Sodium

7. Alginate, Sodium Calcium

8. Alginates

9. Alginic Acid, Barium Salt

10. Alginic Acid, Calcium Salt

11. Alginic Acid, Copper Salt

12. Alginic Acid, Potassium Salt

13. Alginic Acid, Sodium Salt

14. Alloid G

15. Barium Alginate

16. Calcium Alginate

17. Calcium Alginate, Sodium

18. Calginat

19. Copper Alginate

20. Kalrostat

21. Kalrostat 2

22. Kaltostat

23. Poly(mannuronic Acid), Sodium Salt

24. Potassium Alginate

25. Sodium Alginate

26. Sodium Calcium Alginate

27. Vocoloid

28. Xantalgin

2.2.2 Depositor-Supplied Synonyms

1. Sodium Alginate

2. 9005-38-3

3. Natriumglucuronat

4. Schembl20919851

5. Ft-0621962

6. Ft-0670280

7. Sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate

2.3 Create Date

2005-09-18

3 Chemical and Physical Properties

Molecular Formula	C₆H₉NaO₇
Molecular Weight	216.12 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	216.02459690 g/mol
Monoisotopic Mass	216.02459690 g/mol
Topological Polar Surface Area	130 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	210
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	5
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

Mesh Heading: Radiation-protective agents, hemostatics, biocompatible materials

National Library of Medicine, SIS; ChemIDplus Record for Algin (9005-38-3). Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

EXPTL USE: Alginate therapy (20 mg Na alginate; 40 mg manucol SS/LD/2) applied immediately after single oral contaminantion with radiostrontium (0.2-0.4 uCi/mL) reduced skeletal retention of radiostrontium.

KADIC M; VETERINARIA (SARAJAVO) 24 (2) 219-34 (1975)

EXPTL USE: Alginated bread fed to mice increased (85)Sr concentration in blood, decreased urinary excretion and increased fecal excretion.

VAN DER BORGHT ET AL; MINER METAB LAB, STUDIECENT KERNENERG CENT ETUDE ENERG NUCL, MOL, BELG

EXPTL USE: Absorption in mice of strontium, barium, and radium was depressed more than that of calcium by alginates tested, include sodium alginate.

HUMPHREYS ET AL; INT CONF STRONTIUM METAB (PAP) 2ND; VOL CONF-720818, 1973, 309-314

For more Therapeutic Uses (Complete) data for ALGIN (8 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

Apparently ... not decomposed or absorbed appreciably when ingested ...

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-155

When propyleneglycol (14)C alginate or (14)C propylene glycol alginate ... dosed to mice, unhydrolyzed ester and alginate residue ... unabsorbed from GI tract; but any hydrolyzed propyleneglycol ... absorbed ... metabolized and eliminated ... single dose ... 1 g/kg ... excreted ... feces ... 5 days ...

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 343

... After a dose of 5 g/kg, traces of label were still present in rectum. Alginate prepared from laminaria digitata was unabsorbed by rats fed at a level of 10% of their daily diet.

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 343