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Chemistry

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Also known as: Silybin a,b (mixture), 802918-57-6, Silybin (a+b), (2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one, Legalon, Silibin
Molecular Formula
C25H22O10
Molecular Weight
482.4  g/mol
InChI Key
SEBFKMXJBCUCAI-DBMPWETRSA-N

Silymarin
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
1 2D Structure

Silymarin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
2.1.2 InChI
InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1
2.1.3 InChI Key
SEBFKMXJBCUCAI-DBMPWETRSA-N
2.1.4 Canonical SMILES
COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
2.1.5 Isomeric SMILES
COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2,3 Dehydrosilybin

2. 2,3-dehydrosilybin

3. Alepa Forte

4. Alepa-forte

5. Ardeyhepan

6. Cefasilymarin

7. Durasilymarin

8. Hepa Loges

9. Hepa Merz Sil

10. Hepa-loges

11. Hepa-merz Sil

12. Hepabesch

13. Hepar Pasc

14. Hepar-pasc

15. Heparsyx

16. Heplant

17. Lagosa

18. Legalon Forte

19. Silibin

20. Silibinin

21. Silibinin A

22. Silibinin B

23. Silybin A

24. Silybin B

25. Silybinin

26. Carsil

27. Karsil

28. Legalon

29. Silimarin

30. Silymarin

2.2.2 Depositor-Supplied Synonyms

1. Silybin A,b (mixture)

2. 802918-57-6

3. Silybin (a+b)

4. (2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

5. Legalon

6. Silibin

7. Silliver

8. Silybine

9. Silymarin

10. Chembl9509

11. Silibinin A-silibinin B Mixt.

12. Schembl14270800

13. Schembl22398934

14. Hy-n0779a

15. Cs-0138778

16. S0508

17. E80721

18. Silybin (mixture Of Silybin A And B) 100 Microg/ml In Acetonitrile

19. (2r,3r)-2,3-dihydro-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydro-1,4-benzodioxin-6-yl]-4h-1-benzopyran-4-one

20. 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine

2.3 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 482.4 g/mol
Molecular Formula C25H22O10
XLogP32.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass482.12129689 g/mol
Monoisotopic Mass482.12129689 g/mol
Topological Polar Surface Area155 Ų
Heavy Atom Count35
Formal Charge0
Complexity750
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)


Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


Protective Agents

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)


4.2 ATC Code

A - Alimentary tract and metabolism

A05 - Bile and liver therapy

A05B - Liver therapy, lipotropics

A05BA - Liver therapy

A05BA03 - Silymarin


API SUPPLIERS

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TAPI Technology & API Services

Israel

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Yangzhou Gami Biochem Co. Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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03

Gnosis by Lesaffre

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Gnosis by Lesaffre

France

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Teva Pharmaceutical Industries

Israel

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Listed Suppliers

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Virtual BoothTAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.

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Silymarin

About the Company : Founded in 1935, TAPI Technology & API Services has a long-standing tradition of advancing health through innovation and dedication. Today, we proudly build upon this legacy, drivi...

Founded in 1935, TAPI Technology & API Services has a long-standing tradition of advancing health through innovation and dedication. Today, we proudly build upon this legacy, driving progress in the pharmaceutical industry. Leveraging our extensive experience and world-class expertise, we deliver one of the most comprehensive API portfolios in the industry with over 350 Products portfolio. Additionally, we provide tailored CDMO services, harnessing our proficiency in diverse technologies to meet our partners' unique needs, ensuring flexibility and excellence in every project.
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02

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Silybin

About the Company : At Gnosis by Lesaffre, we harness the power of microorganisms to transform compounds into usable nutritional actives, probiotics, and nutritional yeasts that benefit human wellbein...

At Gnosis by Lesaffre, we harness the power of microorganisms to transform compounds into usable nutritional actives, probiotics, and nutritional yeasts that benefit human wellbeing. Our process is natural, is sustainable, and will shape the future of the industry. Our process is called biotransformation. We strive to create a world that moves better, digests better, ages better, feels better, and, ultimately, lives better thanks to microorganisms and biotransformation
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03

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Silybin

About the Company : Teva was established in 1901. Our global headquarters are based in Israel. Today we have a portfolio of more than 3,500 medicines, and produce approximately 120 billion tablets and...

Teva was established in 1901. Our global headquarters are based in Israel. Today we have a portfolio of more than 3,500 medicines, and produce approximately 120 billion tablets and capsules a year at 70 manufacturing facilities. We rank among the leading pharmaceutical companies in the world and are active in 60 countries. Approximately 43,000 employees around the world are dedicated to our mission. Building on our strong global footprint, size and scale, Teva is reaffirming its commitment to place people at the center of our strategy, and enable as many as possible to live better, healthier days.
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Silybin

About the Company : Yangzhou Gami Biochem Co., Ltd. is one of the leading exporters of CDCA, UDCA from China. We mainly engaged in sales of biochemical products, API, amino acids, plant extracts, food...

Yangzhou Gami Biochem Co., Ltd. is one of the leading exporters of CDCA, UDCA from China. We mainly engaged in sales of biochemical products, API, amino acids, plant extracts, food & feed additives and other chemical materials in domestic and overseas markets.We work closely with a selected group of factories in China. All the products we supply are produced and analyzed by a highly qualified and experienced team of chemists ensuring quality products to the valued clients all over the world. The dedicated people and new innovative technologies of our contracted factories have enabled our company to supply the highest quality products to our customers worldwide.
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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672597800,"product":"SILYMARIN 80% (BATCH NO. 20220402W)","address":"A-1\/2,MAHENDRU ENCLAVE G T KARNAL ROAD","city":"DELHI,DELHI","supplier":"HANGZHOU XUANDA BIOTECHNOLOGY CO LT","supplierCountry":"CHINA","foreign_port":"NA","customer":"CORAL ORGANICALS","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"29.5","totalValueFC":"18087.6","currency":"USD","unitRateINR":"2464.7","date":"02-Jan-2023","totalValueINR":"1478835","totalValueInUsd":"18087.6","indian_port":"DELHI TKD ICD","hs_no":"29321990","bill_no":"3998136","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A-1\/2,MAHENDRU ENCLAVE G T KARNAL ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688149800,"product":"SILYMARIN 70% UV (NOT FOR MEDICINAL USE)","address":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,","city":"CHENNAI,TAMIL NADU","supplier":"AWELL INGREDIENTS CO LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"DK ENTERPRISES","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"23.9","totalValueFC":"48417.4","currency":"USD","unitRateINR":"1990","date":"01-Jul-2023","totalValueINR":"3979402.602","totalValueInUsd":"48417.4","indian_port":"MADRAS SEA","hs_no":"29329990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701455400,"product":"SILYMARIN(NOT FOR MEDICINAL USE) CAS NO:65666-07-1","address":"NO.28, RAGHUNAYAKULU STREET,,PARKT","city":"CHENNAI,TAMIL NADU","supplier":"NINGBO HI TECH BIOCHEMICALS COLTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DK ENTERPRISES","customerCountry":"INDIA","quantity":"2500.00","actualQuantity":"2500","unit":"KGS","unitRateFc":"24.3","totalValueFC":"61482.5","currency":"USD","unitRateINR":"2047.2","date":"02-Dec-2023","totalValueINR":"5117998.12","totalValueInUsd":"61482.5","indian_port":"Madras Sea","hs_no":"29329990","bill_no":"9038205","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROO 602, ONE CULTURE PLAZA, NO.1349LIYUAN NORTH ROAD, NINGBOCHINA CN","customerAddress":"NO.28, RAGHUNAYAKULU STREET,,PARKT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"SILYMARINE (BATCH NO: 71315001924) (FOR PHARMACEUTICAL USE-ACTIVE PHARMA INGRIDENT)","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"TEVA API BV","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"SUN PHARMACEUTICAL INDUSTRIES LTD","customerCountry":"INDIA","quantity":"125.00","actualQuantity":"125","unit":"KGS","unitRateFc":"500","totalValueFC":"63095.7","currency":"USD","unitRateINR":"42300","date":"27-Sep-2024","totalValueINR":"5287500","totalValueInUsd":"63095.7","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"5825384","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 107 1019 GM AMSTERDAM NETHERLANDS NL","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"}]
02-Jan-2023
27-Sep-2024
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Europe

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Acino Pharma Ag

Switzerland
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Milk Thistle Dry Extract|Refined And Standardized|Thiamine Hydrochloride|Pyridoxine Hydrochloride|Riboflavin|Nicotinamide|Calcium Pantothenate|Cyanocobalamin

Brand Name : Simepar-Acino

Dosage Form : Capsule

Dosage Strength :

Packaging :

Approval Date : 10/12/1976

Application Number : 38625

Regulatory Info : Allowed

Registration Country : Switzerland

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Silybin

Brand Name :

Dosage Form : CAPSULE

Dosage Strength : 70MG

Packaging : 30 Capsules

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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Silybin

Brand Name :

Dosage Form : CAPSULE

Dosage Strength : 140MG

Packaging : 30 Capsules

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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BIOHEALTH PHARMACEUTICALS Srl

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BIOHEALTH PHARMACEUTICALS Srl

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Silybin

Brand Name : Silmar

Dosage Form :

Dosage Strength : 30 Cps 200 Mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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GERMED PLIVA PHARMA SpA

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GERMED PLIVA PHARMA SpA

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Silybin

Brand Name : Silimarin

Dosage Form :

Dosage Strength : 30 Cpr Riv 200 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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MADAUS Srl

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MADAUS Srl

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Silybin

Brand Name : Legalon 200

Dosage Form :

Dosage Strength : 30 Bust Grat Eff 200 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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MADAUS Srl

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MADAUS Srl

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Silybin

Brand Name : Legalon 140

Dosage Form :

Dosage Strength : 30 Cpr Riv 140 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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MADAUS Srl

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MADAUS Srl

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Silybin

Brand Name : Legalon

Dosage Form :

Dosage Strength : The Scir 150 Ml 1%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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MADAUS Srl

Country
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MADAUS Srl

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Silybin

Brand Name : Legalon 70

Dosage Form :

Dosage Strength : 40 Cpr Riv 70 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Cooper Consumer Health Bv

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Silymarin

Brand Name : Legalon

Dosage Form : Capsule

Dosage Strength : 150MG

Packaging :

Approval Date : 1974-03-01

Application Number : 52190

Regulatory Info : Authorized

Registration Country : Spain

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ABOUT THIS PAGE

Looking for 802918-57-6 / Silymarin API manufacturers, exporters & distributors?

Silymarin manufacturers, exporters & distributors 1

77

PharmaCompass offers a list of Silymarin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Silymarin manufacturer or Silymarin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Silymarin manufacturer or Silymarin supplier.

PharmaCompass also assists you with knowing the Silymarin API Price utilized in the formulation of products. Silymarin API Price is not always fixed or binding as the Silymarin Price is obtained through a variety of data sources. The Silymarin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Silymarin

Synonyms

Silybin a,b (mixture), 802918-57-6, Silybin (a+b), (2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one, Legalon, Silibin

Cas Number

802918-57-6

About Silymarin

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

Silymarin Manufacturers

A Silymarin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Silymarin, including repackagers and relabelers. The FDA regulates Silymarin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Silymarin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Silymarin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Silymarin Suppliers

A Silymarin supplier is an individual or a company that provides Silymarin active pharmaceutical ingredient (API) or Silymarin finished formulations upon request. The Silymarin suppliers may include Silymarin API manufacturers, exporters, distributors and traders.

click here to find a list of Silymarin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Silymarin GMP

Silymarin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Silymarin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Silymarin GMP manufacturer or Silymarin GMP API supplier for your needs.

Silymarin CoA

A Silymarin CoA (Certificate of Analysis) is a formal document that attests to Silymarin's compliance with Silymarin specifications and serves as a tool for batch-level quality control.

Silymarin CoA mostly includes findings from lab analyses of a specific batch. For each Silymarin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Silymarin may be tested according to a variety of international standards, such as European Pharmacopoeia (Silymarin EP), Silymarin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Silymarin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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