Sevelamer Hydrochloride Sevelamer Hydrochloride

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Sevelamer Hydrochloride
Also known as: Sevelamer hcl, 152751-57-0, 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride, 182683-00-7, Chebi:32127, Bcp21176
Molecular Formula
C6H13Cl2NO
Molecular Weight
186.08  g/mol
InChI Key
KHNXRSIBRKBJDI-UHFFFAOYSA-N

A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
1 2D Structure

Sevelamer Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C3H5ClO.C3H7N.ClH/c4-1-3-2-5-3;1-2-3-4;/h3H,1-2H2;2H,1,3-4H2;1H
2.1.3 InChI Key
KHNXRSIBRKBJDI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C=CCN.C1C(O1)CCl.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Carbonate, Sevelamer

2. Gt335 012

3. Gt335-012

4. Gt335012

5. Hydrochloride, Sevelamer

6. Renagel

7. Sevelamer

8. Sevelamer Carbonate

2.2.2 Depositor-Supplied Synonyms

1. Sevelamer Hcl

2. 152751-57-0

3. 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride

4. 182683-00-7

5. Chebi:32127

6. Bcp21176

7. Cga75157

8. Sevelamer Hydrochloride (jan/usan)

9. S4129

10. Akos025149504

11. Ac-2089

12. Hs-0082

13. Db-063954

14. Ft-0653684

15. D01983

16. Ab01568265_01

17. 2-propen-1-amine Hydrochloride Polymer With (chloromethyl)oxirane

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 186.08 g/mol
Molecular Formula C6H13Cl2NO
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass185.0374194 g/mol
Monoisotopic Mass185.0374194 g/mol
Topological Polar Surface Area38.6 Ų
Heavy Atom Count10
Formal Charge0
Complexity55.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Tasermity is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis. Sevelamer hydrochloride should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25 dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]
5.3 ATC Code

V03AE02


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  • TABLET;ORAL - 400MG
  • TABLET;ORAL - 800MG
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