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Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

CEP/COS Certifications

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JDMF

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KDMF

KDMF

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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Chemistry

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Also known as: Rx-3117, 865838-26-2, Roducitabine, Rx3117, Tv-1360, Roducitabine [usan]
Molecular Formula
C10H12FN3O4
Molecular Weight
257.22  g/mol
InChI Key
QLLGKCJUPWYJON-HLTSFMKQSA-N
FDA UNII
0Z4A82I0JO

RX-3117
Roducitabine is an orally available small molecule and nucleoside antimetabolite with potential antineoplastic activity. Upon administration, tRoducitabine is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway.
1 2D Structure

RX-3117

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one
2.1.2 InChI
InChI=1S/C10H12FN3O4/c11-6-4(3-15)8(16)9(17)7(6)14-2-1-5(12)13-10(14)18/h1-2,7-9,15-17H,3H2,(H2,12,13,18)/t7-,8-,9+/m1/s1
2.1.3 InChI Key
QLLGKCJUPWYJON-HLTSFMKQSA-N
2.1.4 Canonical SMILES
C1=CN(C(=O)N=C1N)C2C(C(C(=C2F)CO)O)O
2.1.5 Isomeric SMILES
C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H](C(=C2F)CO)O)O
2.2 Other Identifiers
2.2.1 UNII
0Z4A82I0JO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Rx-3117

2. Tv-1360

2.3.2 Depositor-Supplied Synonyms

1. Rx-3117

2. 865838-26-2

3. Roducitabine

4. Rx3117

5. Tv-1360

6. Roducitabine [usan]

7. Rx 3117

8. 0z4a82i0jo

9. 4-amino-1-[(1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one

10. 1-[(1s,4r,5s)-2-fluoro-3-(hydroxymethyl)-4,5-dihydroxy-2-cyclopentenyl]cytosine

11. 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl)-2(1h)-pyrimidinone

12. 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl)pyrimidin-2(1h)-one

13. 4-amino-1-[(1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2(1h)-pyrimidinone

14. 4-amino-1-[(1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]-1,2-dihydropyrimidin-2-one

15. 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl)pyrimidin-2-one

16. 4-amino-1-[(1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1h)-one

17. Fluorocyclopentenyl Cytosine

18. Fluorocyclopentenyl-cytosine

19. Roducitabine [inn]

20. Unii-0z4a82i0jo

21. Schembl4409591

22. Chembl2064455

23. Chebi:147412

24. Dtxsid101113297

25. Ex-a4776

26. Nsc785657

27. Who 11374

28. Zinc84651969

29. Cs-3947

30. Nsc-785657

31. Ncgc00485875-01

32. Ncgc00485875-02

33. Ac-35336

34. Hy-15228

35. A900305

36. S900007480

37. 2(1h)-pyrimidinone, 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl)-

38. 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl) Cyclopent-2-en-1-yl) Pyrimidin-2-one

39. 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-cyclopent-2-en-1-yl)-pyrimidin-2(1h)-one

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 257.22 g/mol
Molecular Formula C10H12FN3O4
XLogP3-2.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass257.08118403 g/mol
Monoisotopic Mass257.08118403 g/mol
Topological Polar Surface Area119 Ų
Heavy Atom Count18
Formal Charge0
Complexity474
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 865838-26-2 / RX-3117 API manufacturers, exporters & distributors?

RX-3117 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of RX-3117 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right RX-3117 manufacturer or RX-3117 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred RX-3117 manufacturer or RX-3117 supplier.

PharmaCompass also assists you with knowing the RX-3117 API Price utilized in the formulation of products. RX-3117 API Price is not always fixed or binding as the RX-3117 Price is obtained through a variety of data sources. The RX-3117 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

RX-3117

Synonyms

865838-26-2, Roducitabine, Rx3117, Tv-1360, Roducitabine [usan], Rx 3117

Cas Number

865838-26-2

Unique Ingredient Identifier (UNII)

0Z4A82I0JO

About RX-3117

Roducitabine is an orally available small molecule and nucleoside antimetabolite with potential antineoplastic activity. Upon administration, tRoducitabine is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway.

RX 3117 Manufacturers

A RX 3117 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of RX 3117, including repackagers and relabelers. The FDA regulates RX 3117 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. RX 3117 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

RX 3117 Suppliers

A RX 3117 supplier is an individual or a company that provides RX 3117 active pharmaceutical ingredient (API) or RX 3117 finished formulations upon request. The RX 3117 suppliers may include RX 3117 API manufacturers, exporters, distributors and traders.

RX 3117 GMP

RX 3117 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of RX 3117 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right RX 3117 GMP manufacturer or RX 3117 GMP API supplier for your needs.

RX 3117 CoA

A RX 3117 CoA (Certificate of Analysis) is a formal document that attests to RX 3117's compliance with RX 3117 specifications and serves as a tool for batch-level quality control.

RX 3117 CoA mostly includes findings from lab analyses of a specific batch. For each RX 3117 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

RX 3117 may be tested according to a variety of international standards, such as European Pharmacopoeia (RX 3117 EP), RX 3117 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (RX 3117 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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