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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

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Europe

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Australia

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Listed Dossiers

Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 9-nitrocamptothecin, 91421-42-0, 9-nitro-20(s)-camptothecin, Orathecin, 9-nc, Camptogen
Molecular Formula
C20H15N3O6
Molecular Weight
393.3  g/mol
InChI Key
VHXNKPBCCMUMSW-FQEVSTJZSA-N
FDA UNII
H19C446XXB

Rubitecan
Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)
1 2D Structure

Rubitecan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
2.1.2 InChI
InChI=1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
2.1.3 InChI Key
VHXNKPBCCMUMSW-FQEVSTJZSA-N
2.1.4 Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5[N+](=O)[O-])N=C4C3=C2)O
2.1.5 Isomeric SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5[N+](=O)[O-])N=C4C3=C2)O
2.2 Other Identifiers
2.2.1 UNII
H19C446XXB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 9-nitro-20(s)-camptothecin

2. 9-nitrocamptothecin

3. 9-nitrocamptothecin, (s)-isomer

4. Rfs 2000

5. Rfs-2000

6. Rfs2000

2.3.2 Depositor-Supplied Synonyms

1. 9-nitrocamptothecin

2. 91421-42-0

3. 9-nitro-20(s)-camptothecin

4. Orathecin

5. 9-nc

6. Camptogen

7. Rfs 2000

8. Rfs-2000

9. (s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

10. 86639-62-5

11. Nitrocamptothecin

12. Rubitecan [usan]

13. Chebi:90225

14. Rfs2000

15. Rubitecan [usan:inn]

16. Unii-h19c446xxb

17. 9-nitro-(20s)-camptothecin

18. H19c446xxb

19. 9-nitro-20-(s)-camptothecin

20. Dtxsid7046752

21. Rfs 2000;9-nitrocamptothecin

22. (s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

23. 9nc

24. Ncgc00167969-01

25. (4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

26. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4s)-

27. Rubitecanum

28. Inhaled Orathecin

29. C20h15n3o6

30. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-9-nitro-

31. 1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-9-nitro-

32. Rubitecan (inhaled)

33. 9-nitro Camptothecin

34. Rubitecan [inn]

35. Rubitecan [mi]

36. Rubitecan (usan/inn)

37. L9nc

38. D0i5xo

39. D0y1fo

40. Rubitecan [mart.]

41. Rubitecan [who-dd]

42. Schembl8640

43. 9-nitrocamptothecin (9-nc)

44. Ethyl-hydroxy-nitro-[?]dione

45. Chembl77305

46. Rubitecan (inhaled), Supergen

47. Camptothecin, 9-nitro-20(s)

48. Dtxcid5026752

49. Vhxnkpbccmumsw-fqevstjzsa-n

50. Bcp06207

51. Ex-a4326

52. Tox21_112597

53. Bdbm50248354

54. Mfcd06656294

55. S2288

56. Akos015895332

57. Akos025149224

58. C20-h15-n3-o6

59. Db06159

60. St-2617

61. Ncgc00167969-02

62. Ncgc00167969-03

63. Ac-13389

64. Ac-25083

65. Ac-33157

66. As-14856

67. Hy-13744

68. Cas-91421-42-0

69. Cs-0007769

70. N0822

71. D04031

72. A847954

73. Q510113

74. Aerosolized Liposomal 9 Nitro-20 (s) Camptothecin

75. Q-100889

76. Brd-k79821389-001-01-9

77. (19s)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

78. (s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3\',4\':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 393.3 g/mol
Molecular Formula C20H15N3O6
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area126
Heavy Atom Count29
Formal Charge0
Complexity861
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified).


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Topoisomerase I Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)


5.2 Mechanism of Action

Rubitecan prevents DNA from unwinding during replication via DNA topoisomerase 1, therefore interfering with tumor growth.


ABOUT THIS PAGE

Looking for 91421-42-0 / Rubitecan API manufacturers, exporters & distributors?

Rubitecan manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Rubitecan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rubitecan manufacturer or Rubitecan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rubitecan manufacturer or Rubitecan supplier.

PharmaCompass also assists you with knowing the Rubitecan API Price utilized in the formulation of products. Rubitecan API Price is not always fixed or binding as the Rubitecan Price is obtained through a variety of data sources. The Rubitecan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rubitecan

Synonyms

9-nitrocamptothecin, 91421-42-0, 9-nitro-20(s)-camptothecin, Orathecin, 9-nc, Camptogen

Cas Number

91421-42-0

Unique Ingredient Identifier (UNII)

H19C446XXB

About Rubitecan

Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)

Rubitecan Manufacturers

A Rubitecan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rubitecan, including repackagers and relabelers. The FDA regulates Rubitecan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rubitecan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Rubitecan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Rubitecan Suppliers

A Rubitecan supplier is an individual or a company that provides Rubitecan active pharmaceutical ingredient (API) or Rubitecan finished formulations upon request. The Rubitecan suppliers may include Rubitecan API manufacturers, exporters, distributors and traders.

click here to find a list of Rubitecan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rubitecan GMP

Rubitecan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rubitecan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rubitecan GMP manufacturer or Rubitecan GMP API supplier for your needs.

Rubitecan CoA

A Rubitecan CoA (Certificate of Analysis) is a formal document that attests to Rubitecan's compliance with Rubitecan specifications and serves as a tool for batch-level quality control.

Rubitecan CoA mostly includes findings from lab analyses of a specific batch. For each Rubitecan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rubitecan may be tested according to a variety of international standards, such as European Pharmacopoeia (Rubitecan EP), Rubitecan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rubitecan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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