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Chemistry

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Also known as: Gmi-1070, Pf-06460031, 927881-99-0, 4b115v09lb, (s)-2-(((2r,3r,4s,5s,6r)-3-(benzoyloxy)-2-(((1r,2r,3s,5r)-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamido)-5-((2-(2-(2-(2-oxo-2-((3,6,8-trisulfonaphthalen-1-yl)amino)ethoxy)ethoxy)acetamido)ethyl)carbamoyl)-2-(((2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-, Rivipansel [usan]
Molecular Formula
C58H74N6O31S3
Molecular Weight
1447.4  g/mol
InChI Key
VXBNTHRZPJLRSS-PTCSXESPSA-N
FDA UNII
4B115V09LB

Rivipansel
Rivipansel is a synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, rivipansel prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.
1 2D Structure

Rivipansel

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[(2R,3R,4S,5S,6R)-3-benzoyloxy-2-[(1R,2R,3S,5R)-3-[(2,4-dioxo-1H-pyrimidine-6-carbonyl)amino]-5-[2-[[2-[2-[2-oxo-2-[(3,6,8-trisulfonaphthalen-1-yl)amino]ethoxy]ethoxy]acetyl]amino]ethylcarbamoyl]-2-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxycyclohexyl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-cyclohexylpropanoic acid
2.1.2 InChI
InChI=1S/C58H74N6O31S3/c1-27-45(69)47(71)48(72)56(90-27)95-49-35(62-53(74)36-23-41(66)64-58(78)63-36)19-31(20-37(49)92-57-51(94-55(77)29-10-6-3-7-11-29)50(46(70)39(24-65)93-57)91-38(54(75)76)16-28-8-4-2-5-9-28)52(73)60-13-12-59-42(67)25-88-14-15-89-26-43(68)61-34-21-32(96(79,80)81)17-30-18-33(97(82,83)84)22-40(44(30)34)98(85,86)87/h3,6-7,10-11,17-18,21-23,27-28,31,35,37-39,45-51,56-57,65,69-72H,2,4-5,8-9,12-16,19-20,24-26H2,1H3,(H,59,67)(H,60,73)(H,61,68)(H,62,74)(H,75,76)(H,79,80,81)(H,82,83,84)(H,85,86,87)(H2,63,64,66,78)/t27-,31+,35-,37+,38-,39+,45+,46-,47+,48-,49+,50-,51+,56-,57+/m0/s1
2.1.3 InChI Key
VXBNTHRZPJLRSS-PTCSXESPSA-N
2.1.4 Canonical SMILES
CC1C(C(C(C(O1)OC2C(CC(CC2OC3C(C(C(C(O3)CO)O)OC(CC4CCCCC4)C(=O)O)OC(=O)C5=CC=CC=C5)C(=O)NCCNC(=O)COCCOCC(=O)NC6=C7C(=CC(=C6)S(=O)(=O)O)C=C(C=C7S(=O)(=O)O)S(=O)(=O)O)NC(=O)C8=CC(=O)NC(=O)N8)O)O)O
2.1.5 Isomeric SMILES
C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H](C[C@H](C[C@H]2O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O[C@@H](CC4CCCCC4)C(=O)O)OC(=O)C5=CC=CC=C5)C(=O)NCCNC(=O)COCCOCC(=O)NC6=C7C(=CC(=C6)S(=O)(=O)O)C=C(C=C7S(=O)(=O)O)S(=O)(=O)O)NC(=O)C8=CC(=O)NC(=O)N8)O)O)O
2.2 Other Identifiers
2.2.1 UNII
4B115V09LB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Gmi-1070

2.3.2 Depositor-Supplied Synonyms

1. Gmi-1070

2. Pf-06460031

3. 927881-99-0

4. 4b115v09lb

5. (s)-2-(((2r,3r,4s,5s,6r)-3-(benzoyloxy)-2-(((1r,2r,3s,5r)-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamido)-5-((2-(2-(2-(2-oxo-2-((3,6,8-trisulfonaphthalen-1-yl)amino)ethoxy)ethoxy)acetamido)ethyl)carbamoyl)-2-(((2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-

6. Rivipansel [usan]

7. 1189037-60-2

8. Rivipansel [usan:inn]

9. Unii-4b115v09lb

10. Starbld0029722

11. Rivipansel [inn]

12. Rivipansel (usan/inn)

13. Rivipansel [who-dd]

14. Gtpl8307

15. Chembl3707446

16. Schembl22657110

17. Db12778

18. D10487

19. Q27088557

20. (2s)-2-[(2r,3r,4s,5s,6r)-3-benzoyloxy-2-[(1r,2r,3s,5r)-3-[(2,4-dioxo-1h-pyrimidine-6-carbonyl)amino]-5-[2-[[2-[2-[2-oxo-2-[(3,6,8-trisulfonaphthalen-1-yl)amino]ethoxy]ethoxy]acetyl]amino]ethylcarbamoyl]-2-[(2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxycyclohexyl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-cyclohexylpropanoic Acid

2.4 Create Date
2009-10-19
3 Chemical and Physical Properties
Molecular Weight 1447.4 g/mol
Molecular Formula C58H74N6O31S3
XLogP3-2.6
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count31
Rotatable Bond Count30
Exact Mass1446.3560631 g/mol
Monoisotopic Mass1446.3560631 g/mol
Topological Polar Surface Area592 Ų
Heavy Atom Count98
Formal Charge0
Complexity3190
Isotope Atom Count0
Defined Atom Stereocenter Count15
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 927881-99-0 / Rivipansel API manufacturers, exporters & distributors?

Rivipansel manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Rivipansel API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rivipansel manufacturer or Rivipansel supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rivipansel manufacturer or Rivipansel supplier.

PharmaCompass also assists you with knowing the Rivipansel API Price utilized in the formulation of products. Rivipansel API Price is not always fixed or binding as the Rivipansel Price is obtained through a variety of data sources. The Rivipansel Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rivipansel

Synonyms

Gmi-1070, Pf-06460031, 927881-99-0, 4b115v09lb, (s)-2-(((2r,3r,4s,5s,6r)-3-(benzoyloxy)-2-(((1r,2r,3s,5r)-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamido)-5-((2-(2-(2-(2-oxo-2-((3,6,8-trisulfonaphthalen-1-yl)amino)ethoxy)ethoxy)acetamido)ethyl)carbamoyl)-2-(((2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-, Rivipansel [usan]

Cas Number

927881-99-0

Unique Ingredient Identifier (UNII)

4B115V09LB

About Rivipansel

Rivipansel is a synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, rivipansel prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.

Rivipansel Manufacturers

A Rivipansel manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rivipansel, including repackagers and relabelers. The FDA regulates Rivipansel manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rivipansel API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rivipansel Suppliers

A Rivipansel supplier is an individual or a company that provides Rivipansel active pharmaceutical ingredient (API) or Rivipansel finished formulations upon request. The Rivipansel suppliers may include Rivipansel API manufacturers, exporters, distributors and traders.

Rivipansel GMP

Rivipansel Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rivipansel GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rivipansel GMP manufacturer or Rivipansel GMP API supplier for your needs.

Rivipansel CoA

A Rivipansel CoA (Certificate of Analysis) is a formal document that attests to Rivipansel's compliance with Rivipansel specifications and serves as a tool for batch-level quality control.

Rivipansel CoA mostly includes findings from lab analyses of a specific batch. For each Rivipansel CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rivipansel may be tested according to a variety of international standards, such as European Pharmacopoeia (Rivipansel EP), Rivipansel JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rivipansel USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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