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Chemistry

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Also known as: Chloroquine diphosphate, 50-63-5, Resochin, Arechin, Aralen phosphate, Chingamin phosphate
Molecular Formula
C18H32ClN3O8P2
Molecular Weight
515.9  g/mol
InChI Key
QKICWELGRMTQCR-UHFFFAOYSA-N
FDA UNII
6E17K3343P

Chloroquine Phosphate
Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.
1 2D Structure

Chloroquine Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
2.1.2 InChI
InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
2.1.3 InChI Key
QKICWELGRMTQCR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
6E17K3343P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arechin

2. Chingamin Phosphate

3. Chloroquine Bis(dihydrogenphosphate) Dihydrate

4. Chloroquine Diphosphate

5. Chloroquine Diphosphate, (+)-isomer

6. Chloroquine Diphosphate, (+-)-isomer

7. Chloroquine Diphosphate, (-)-isomer

8. Delagil

9. Khingamin Phosphate

10. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

11. Resochin

12. Unspecified Phosphate Of Chloroquine Diphosphate

2.3.2 Depositor-Supplied Synonyms

1. Chloroquine Diphosphate

2. 50-63-5

3. Resochin

4. Arechin

5. Aralen Phosphate

6. Chingamin Phosphate

7. Chloroquine Bis(phosphate)

8. Chloroquine Diphosphate Salt

9. Avloclor

10. Delagil

11. Chloroquine (phosphate)

12. Khingamin

13. Miniquine

14. Tanakan

15. Tanakene

16. Aralen Diphosphate

17. Gontochin Phosphate

18. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-1,4-diamine Bis(phosphate)

19. Chloroquin Diphosphate

20. Nsc 14050

21. Ipsen 225

22. Chloroquinediphosphate

23. Mfcd00069852

24. 3377 Rp

25. 50-63-5 (diphosphate)

26. Sn 7,618

27. Nsc-14050

28. 6e17k3343p

29. Sn-7618

30. Wr-1522

31. Chingaminum

32. Alermine

33. H-stadur

34. Dsstox_cid_24681

35. Dsstox_rid_80393

36. Dsstox_gsid_44681

37. 1,4-pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-n(sup 1),n(sup 1)-diethyl-, Phosphate (1:2)

38. Chlorochin Diphosphate

39. Tanakan (antimalarial)

40. 4-n-(7-chloroquinolin-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;phosphoric Acid

41. Dl-chloroquine Diphosphate

42. Ccris 1554

43. Sr-01000075548

44. Einecs 200-055-2

45. Wr 1522

46. Chloroquine Dihydrogen Phosphate (1:2)

47. Unikinon

48. Ai3-14952

49. Unii-6e17k3343p

50. Chloroquine Phosphate [usp:ban]

51. Chloroquindiphosphat

52. Chloroquini Phosphas

53. Prestwick_867

54. Aralen (tn)

55. Cas-50-63-5

56. Ncgc00015256-01

57. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat [german]

58. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2)

59. N4-(7-chloro-4-quinolinyl)-n1,n1-dimethyl-1,4-pentanediamine Diphosphate Salt

60. Chloroquine Diphosphate,(s)

61. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n1,n1-diethyl-, Phosphate (1:2)

62. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

63. 1,4-diamine Bis(phosphate)

64. Chloroquine Phosphate (usp)

65. Schembl40827

66. Chembl58510

67. Spectrum1500179

68. Chloroquine Diphosphate, Sulfate

69. Dtxsid7044681

70. Hms501e06

71. Hms1569n17

72. Hms1920o05

73. Hms2091c16

74. Hms2096n17

75. Hms3260l14

76. Hms3713n17

77. Bcp31956

78. Chloroquine Diphosphate [mi]

79. Tox21_110115

80. Tox21_202838

81. Tox21_500296

82. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat

83. Ccg-39643

84. Chloroquine Phosphate [vandf]

85. S4157

86. Chloroquine Phosphate [mart.]

87. Akos004910410

88. Chloroquine Phosphate [usp-rs]

89. Chloroquine Phosphate [who-dd]

90. Chloroquine Phosphate [who-ip]

91. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-pentane-1,4-diamine; Phosphoric Acid

92. Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, Diphosphate

93. Tox21_110115_1

94. Cs-3811

95. Dt-0015

96. Lp00296

97. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n',n'-diethyl-, (+-)-, Phosphate (1:2)

98. Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, Phosphate (1:2)

99. Ncgc00015256-12

100. Ncgc00093746-01

101. Ncgc00093746-02

102. Ncgc00093746-03

103. Ncgc00260384-01

104. Ncgc00260981-01

105. Ac-12463

106. Chloroquine Phosphate [green Book]

107. Hy-17589

108. Sy021941

109. Chloroquine Phosphate [orange Book]

110. Chloroquine Phosphate [ep Monograph]

111. Chloroquini Phosphas [who-ip Latin]

112. Db-051808

113. Chloroquine Diphosphate Salt, Solid, >=98%

114. Chloroquine Phosphate [usp Monograph]

115. Eu-0100296

116. Ft-0602804

117. C 6628

118. D02125

119. D70732

120. 069c852

121. A828213

122. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-

123. Sr-01000075548-1

124. Sr-01000075548-3

125. Sr-01000075548-5

126. Q27264629

127. F2173-1139

128. 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline Phosphate

129. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Bis(phosphate)

130. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate

131. Chloroquine Phosphate, United States Pharmacopeia (usp) Reference Standard

132. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-1,4-pentanediamine Diphosphate

133. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2).

134. Chloroquine Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

135. Chloroquine Phosphate;aralen Phosphate;7-chloro-4-((4 Inverted Exclamation Mark -diethylamino-1-methylbutyl)amino)quinolinediphosphate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 515.9 g/mol
Molecular Formula C18H32ClN3O8P2
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Exact Mass515.1353167 g/mol
Monoisotopic Mass515.1353167 g/mol
Topological Polar Surface Area184 Ų
Heavy Atom Count32
Formal Charge0
Complexity359
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameChloroquine phosphate
Drug LabelChloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
Active IngredientChloroquine phosphate
Dosage FormTablet
RouteOral
Strengtheq 300mg base; eq 150mg base
Market StatusPrescription
CompanyIpca Labs; Natco Pharma; Hikma Pharms; Impax Labs

2 of 2  
Drug NameChloroquine phosphate
Drug LabelChloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
Active IngredientChloroquine phosphate
Dosage FormTablet
RouteOral
Strengtheq 300mg base; eq 150mg base
Market StatusPrescription
CompanyIpca Labs; Natco Pharma; Hikma Pharms; Impax Labs

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Antimalarials

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)


Filaricides

Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Antimalarial [EPC]

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(CHLOROQUINE PHOSPHATE)","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"ADEN","customer":"TO ORDER OF","customerCountry":"YEMEN","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"34","totalValueFC":"18975.7","currency":"EURO","unitRateINR":3248.6999999999998,"date":"26-Apr-2025","totalValueINR":"1624350","totalValueInUsd":"18975.7","indian_port":"Bombay Air","hs_no":"29392040","bill_no":"1285554","productDescription":"API","marketType":"","country":"YEMEN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1648146600,"product":"CHLOROQUINE PHOSPHATE USP 20090468, LOT NO:CQP\/A\/0130620","address":"901-911 9TH FLR ISCON ELEGANCE NR SHAPATH 5 S G HIGHWAY Contact No: 9","city":"AHMEDABAD","supplier":"AMNEAL PHARMACEUTICALS OF LLC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"AMNEAL PHARMACEUTICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"147.64","actualQuantity":"147.643","unit":"KGS","unitRateFc":"1850","totalValueFC":"366748.4","currency":"USD","unitRateINR":"189330.9","date":"25-Mar-2022","totalValueINR":"27953387.26","totalValueInUsd":"366748.4","indian_port":"AHMEDABAD AIR","hs_no":"29392040","bill_no":"8014268","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"901-911 9TH FLR ISCON ELEGANCE NR SHAPATH 5 S G HIGHWAY Contact No: 9"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"CHLOROQUINE PHOSPHATE (QTY:2 X 200 MG, VALUE: USD 240\/EACH)(FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL CONVETION","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIAINDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0004","unit":"KGS","unitRateFc":"1200000","totalValueFC":"516.5","currency":"USD","unitRateINR":"107797050","date":"27-Jun-2024","totalValueINR":"43118.82","totalValueInUsd":"516.5","indian_port":"Hyderabad Air","hs_no":"29334900","bill_no":"4214387","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD, US 21704SDNF United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]
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26-Apr-2025
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ABOUT THIS PAGE

Looking for 50-63-5 / Chloroquine Phosphate API manufacturers, exporters & distributors?

Chloroquine Phosphate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Chloroquine Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chloroquine Phosphate manufacturer or Chloroquine Phosphate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chloroquine Phosphate manufacturer or Chloroquine Phosphate supplier.

PharmaCompass also assists you with knowing the Chloroquine Phosphate API Price utilized in the formulation of products. Chloroquine Phosphate API Price is not always fixed or binding as the Chloroquine Phosphate Price is obtained through a variety of data sources. The Chloroquine Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Chloroquine Phosphate

Synonyms

Chloroquine diphosphate, 50-63-5, Resochin, Arechin, Aralen phosphate, Chingamin phosphate

Cas Number

50-63-5

Unique Ingredient Identifier (UNII)

6E17K3343P

About Chloroquine Phosphate

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

Resochin Manufacturers

A Resochin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Resochin, including repackagers and relabelers. The FDA regulates Resochin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Resochin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Resochin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Resochin Suppliers

A Resochin supplier is an individual or a company that provides Resochin active pharmaceutical ingredient (API) or Resochin finished formulations upon request. The Resochin suppliers may include Resochin API manufacturers, exporters, distributors and traders.

click here to find a list of Resochin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Resochin USDMF

A Resochin DMF (Drug Master File) is a document detailing the whole manufacturing process of Resochin active pharmaceutical ingredient (API) in detail. Different forms of Resochin DMFs exist exist since differing nations have different regulations, such as Resochin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Resochin DMF submitted to regulatory agencies in the US is known as a USDMF. Resochin USDMF includes data on Resochin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Resochin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Resochin suppliers with USDMF on PharmaCompass.

Resochin CEP

A Resochin CEP of the European Pharmacopoeia monograph is often referred to as a Resochin Certificate of Suitability (COS). The purpose of a Resochin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Resochin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Resochin to their clients by showing that a Resochin CEP has been issued for it. The manufacturer submits a Resochin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Resochin CEP holder for the record. Additionally, the data presented in the Resochin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Resochin DMF.

A Resochin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Resochin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Resochin suppliers with CEP (COS) on PharmaCompass.

Resochin WC

A Resochin written confirmation (Resochin WC) is an official document issued by a regulatory agency to a Resochin manufacturer, verifying that the manufacturing facility of a Resochin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Resochin APIs or Resochin finished pharmaceutical products to another nation, regulatory agencies frequently require a Resochin WC (written confirmation) as part of the regulatory process.

click here to find a list of Resochin suppliers with Written Confirmation (WC) on PharmaCompass.

Resochin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Resochin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Resochin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Resochin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Resochin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Resochin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Resochin suppliers with NDC on PharmaCompass.

Resochin GMP

Resochin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Resochin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Resochin GMP manufacturer or Resochin GMP API supplier for your needs.

Resochin CoA

A Resochin CoA (Certificate of Analysis) is a formal document that attests to Resochin's compliance with Resochin specifications and serves as a tool for batch-level quality control.

Resochin CoA mostly includes findings from lab analyses of a specific batch. For each Resochin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Resochin may be tested according to a variety of international standards, such as European Pharmacopoeia (Resochin EP), Resochin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Resochin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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