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Chemistry

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Also known as: 132036-88-5, Ramosetron [inn], (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone, 7zro0sc54y, Chembl1643895, Ramosetron (inn)
Molecular Formula
C17H17N3O
Molecular Weight
279.34  g/mol
InChI Key
NTHPAPBPFQJABD-LLVKDONJSA-N
FDA UNII
7ZRO0SC54Y

Ramosetron
Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.
1 2D Structure

Ramosetron

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1-methylindol-3-yl)-[(5R)-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methanone
2.1.2 InChI
InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1
2.1.3 InChI Key
NTHPAPBPFQJABD-LLVKDONJSA-N
2.1.4 Canonical SMILES
CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4
2.1.5 Isomeric SMILES
CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4
2.2 Other Identifiers
2.2.1 UNII
7ZRO0SC54Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazol

2. Methanone, (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-, Monohydrochloride, (r)-

3. Nasea

4. Ramosetron Hydrochloride

5. Ym 060

6. Ym-060

7. Ym060

2.3.2 Depositor-Supplied Synonyms

1. 132036-88-5

2. Ramosetron [inn]

3. (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone

4. 7zro0sc54y

5. Chembl1643895

6. Ramosetron (inn)

7. (r)-(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzo[d]imidazol-6-yl)methanone

8. Unii-7zro0sc54y

9. Nor-ym 060

10. Ramosetron [mi]

11. Ramosetron [who-dd]

12. Schembl16701

13. Gtpl2301

14. Dtxsid0043842

15. Chebi:135156

16. Zinc5116719

17. Bdbm50334454

18. (-)-(r)-1-methylindol-3-yl 4,5,6,7-tetrahydro-5-benzimidazolylketone

19. Akos015896003

20. Db09290

21. R-146

22. D08466

23. A806353

24. Ar-270/43507766

25. Q2979523

26. (-)-(r)-1-methylindol-3-yl-4,5,6,7-tetrahydro-5-benzimidazolyl Ketone

27. (-)-(r)-1-methylindol-3-yl-4,5,6,7-tetrahydro-5-benzimidazolyl Ketone.

28. (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-6-yl)methanone

29. (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone.

30. (r)-(-)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole

31. (r)-5-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1h-bezimidazole

32. Methanone, (1-methyl-1h-indol-3-yl)[(6r)-4,5,6,7-tetrahydro-1h-benzimidazol-6-yl]-

33. Methanone,(1-methyl-1h-indol-3-yl)[(6r)-4,5,6,7-tetrahydro-1h-benzimidazol-6-yl]-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 279.34 g/mol
Molecular Formula C17H17N3O
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass279.137162174 g/mol
Monoisotopic Mass279.137162174 g/mol
Topological Polar Surface Area50.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


API SUPPLIERS

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Hana Pharm

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ESCRS
Not Confirmed
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Hana Pharm

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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ESCRS
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Polaris AI Pharma

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ESCRS
Not Confirmed
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Polaris AI Pharma

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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ESCRS
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Refarmed Chemicals

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ESCRS
Not Confirmed
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Refarmed Chemicals

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Laboratori Alchemia Srl

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ESCRS
Not Confirmed
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Laboratori Alchemia Srl

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
USDMF CEP/COS JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
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Laboratori Alchemia Srl

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ESCRS
Not Confirmed
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Laboratori Alchemia Srl

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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ESCRS
Not Confirmed
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JDMF

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Ramosetron Hydrochloride

Registration Number : 221MF10177

Registrant's Address : Via San Faustino, 68 20134 Milano-Italy

Initial Date of Registration : 2009-08-07

Latest Date of Registration : 2009-08-07

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Ramosetron Hydrochloride

Registration Number : 226MF10230

Registrant's Address : Via San Faustino, 68 20134 Milano-Italy

Initial Date of Registration : 2014-12-08

Latest Date of Registration : 2014-12-08

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Listed Suppliers

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Hana Pharm

South Korea
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Hana Pharm

South Korea
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ramosetron

About the Company : We, Hana Pharmaceutical Co., Ltd. was founded the name of Woo-Chun Pharmaceutical Company in 1958. We also changed our company name to Hana in 1996. Our aim to support people can ...

We, Hana Pharmaceutical Co., Ltd. was founded the name of Woo-Chun Pharmaceutical Company in 1958. We also changed our company name to Hana in 1996. Our aim to support people can be summarized by the following sentence: " For people's better life, by the better medicine." Located in Hyangnam Pharmaceutical Complex Area, our Sangsin plant was certified on August, 1994 as the KGMP qualified plant and prepared the complete manufacturing system based on Korean Good Manufacturing Practice (KGMP) standard.
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ramosetron

About the Company : Alchemia is dedicated to the production of high-quality active ingredients and intermediates for the pharmaceutical industry. Our goal is to offer products manufactured to the hig...

Alchemia is dedicated to the production of high-quality active ingredients and intermediates for the pharmaceutical industry. Our goal is to offer products manufactured to the highest standards of excellence in accordance with the following business philosophy: • State-of-the-art manufacturing facilities • Process optimization and continued improvement • Ongoing education and training of personnel • Long-term partnerships with suppliers and customers built on transparency • A constant exchange of ideas with the academic community.
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Polaris AI Pharma

South Korea
Coatings Trends
Not Confirmed
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Polaris AI Pharma

South Korea
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Coatings Trends
Not Confirmed

ramosetron

About the Company : Polaris AI Pharma is a dynamic company specializing in innovative pharmaceutical solutions. Leveraging cutting-edge AI technology, it focuses on drug discovery, development, and op...

Polaris AI Pharma is a dynamic company specializing in innovative pharmaceutical solutions. Leveraging cutting-edge AI technology, it focuses on drug discovery, development, and optimization to address unmet medical needs. Committed to advancing healthcare, Polaris AI Pharma combines scientific expertise with digital innovation to deliver impactful treatments.
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Refarmed Chemicals

Switzerland
Coatings Trends
Not Confirmed
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Refarmed Chemicals

Switzerland
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Ramosetron

About the Company : Refarmed Chemicals is a fully integrated Swiss-based marketing company with extensive experience in the generics industry. Our global market activity and strategic offices located ...

Refarmed Chemicals is a fully integrated Swiss-based marketing company with extensive experience in the generics industry. Our global market activity and strategic offices located in India and China give customers the benefit of our expertise in API sourcing, finished formulation and new product development, technical and regulatory support, supply chain logistics, out-licensing and other business development activities. Our presence in over 60 countries gives us a vast network to monitor the latest market developments.
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Drugs in Development

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  • Development Update

Details:

Undisclosed


Lead Product(s): Ramosetron,Aprepitant,Dexamethasone

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Other Small Molecule

Sponsor: Catholic University of Korea | Astellas Pharma

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 26, 2015

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Kangdong Sacred Heart Hospital

Country
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ESCRS
Not Confirmed

Kangdong Sacred Heart Hospital

Country
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ESCRS
Not Confirmed

Lead Product(s) : Ramosetron,Aprepitant,Dexamethasone

Therapeutic Area : Oncology

Highest Development Status : Phase IV

Partner/Sponsor/Collaborator : Catholic University of Korea | Astellas Pharma

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

August 26, 2015

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 06, 2013

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Details:

Undisclosed


Lead Product(s): Ramosetron,Inapplicable

Therapeutic Area: Gastroenterology Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 29, 2012

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 29, 2012

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  • Development Update

Details:

Undisclosed


Lead Product(s): Ramosetron,Inapplicable

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Korean Cancer Study Group | Astellas Pharma

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 22, 2012

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Hallym University Medical Center

Country
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ESCRS
Not Confirmed

Hallym University Medical Center

Country
arrow
ESCRS
Not Confirmed

Lead Product(s) : Ramosetron,Inapplicable

Therapeutic Area : Oncology

Highest Development Status : Phase III

Partner/Sponsor/Collaborator : Korean Cancer Study Group | Astellas Pharma

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

February 22, 2012

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 14, 2011

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 13, 2011

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 11, 2011

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ESCRS
Not Confirmed
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

October 20, 2010

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  • Development Update

Details:

Undisclosed


Lead Product(s): Ramosetron,Aprepitant,Dexamethasone

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: Phase IIProduct Type: Other Small Molecule

Sponsor: Merck & Co

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 12, 2010

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Hallym University Medical Center

Country
arrow
ESCRS
Not Confirmed

Hallym University Medical Center

Country
arrow
ESCRS
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 12, 2010

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INTERMEDIATE SUPPLIERS

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01

ESCRS
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CAS Number : 131020-57-0

End Use API : Ramosetron

About The Company : Polaris AI Pharma is a dynamic company specializing in innovative pharmaceutical solutions. Leveraging cutting-edge AI technology, it focuses on drug discovery,...

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Suraj Labs

India
ESCRS
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Suraj Labs

India
ESCRS
Not Confirmed
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CAS Number : 131020-57-0

End Use API : Ramosetron

About The Company : Suraj Laboratories Private Limited, established in 2021, is a pharmaceutical firm providing Contract Research and Manufacturing Services (CRAMS), Custom Synthes...

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FDF Dossiers

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ramosetron

Brand Name :

Dosage Form : Tablet

Dosage Strength : 0.1MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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Market Place

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Ramosetron manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ramosetron API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ramosetron manufacturer or Ramosetron supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ramosetron manufacturer or Ramosetron supplier.

PharmaCompass also assists you with knowing the Ramosetron API Price utilized in the formulation of products. Ramosetron API Price is not always fixed or binding as the Ramosetron Price is obtained through a variety of data sources. The Ramosetron Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ramosetron

Synonyms

132036-88-5, Ramosetron [inn], (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone, 7zro0sc54y, Chembl1643895, Ramosetron (inn)

Cas Number

132036-88-5

Unique Ingredient Identifier (UNII)

7ZRO0SC54Y

About Ramosetron

Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.

Ramosetron Manufacturers

A Ramosetron manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ramosetron, including repackagers and relabelers. The FDA regulates Ramosetron manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ramosetron API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ramosetron manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ramosetron Suppliers

A Ramosetron supplier is an individual or a company that provides Ramosetron active pharmaceutical ingredient (API) or Ramosetron finished formulations upon request. The Ramosetron suppliers may include Ramosetron API manufacturers, exporters, distributors and traders.

click here to find a list of Ramosetron suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ramosetron JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Ramosetron Drug Master File in Japan (Ramosetron JDMF) empowers Ramosetron API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Ramosetron JDMF during the approval evaluation for pharmaceutical products. At the time of Ramosetron JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Ramosetron suppliers with JDMF on PharmaCompass.

Ramosetron GMP

Ramosetron Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ramosetron GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ramosetron GMP manufacturer or Ramosetron GMP API supplier for your needs.

Ramosetron CoA

A Ramosetron CoA (Certificate of Analysis) is a formal document that attests to Ramosetron's compliance with Ramosetron specifications and serves as a tool for batch-level quality control.

Ramosetron CoA mostly includes findings from lab analyses of a specific batch. For each Ramosetron CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ramosetron may be tested according to a variety of international standards, such as European Pharmacopoeia (Ramosetron EP), Ramosetron JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ramosetron USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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