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Quadramet

Quadramet

Synopsis, Chemistry

DOSSIERs // Finished Dosage Formulations

2 Dossiers, 1 FDA Orange Book, 1 Europe

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Also known as: Quadramet, Cyt-424, 160369-78-8, Samarium sm 153 lexidronam pentasodium, Quadramet (tn), Samarium sm 153 lexidronam pentasodium [usan]

Molecular Formula

C₆H₁₂N₂Na₅O₁₂P₄Sm

Molecular Weight

695.93 g/mol

InChI Key

SZZACTGRBZTAKY-NKNBZPHVSA-F

FDA UNII

7389YR3OOV

Samarium Sm-153 Lexidronam Pentasodium is the pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases.

Samarium sm-153 lexidronam pentasodium is a Radioactive Therapeutic Agent. The mechanism of action of samarium sm-153 lexidronam pentasodium is as a Radiopharmaceutical Activity.

1 2D Structure

Quadramet

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

pentasodium;samarium-153(3+);N,N,N',N'-tetrakis(phosphonatomethyl)ethane-1,2-diamine

2.1.2 InChI

InChI=1S/C6H20N2O12P4.5Na.Sm/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20;;;;;;/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;;;/q;5*+1;+3/p-8/i;;;;;;1+3

2.1.3 InChI Key

SZZACTGRBZTAKY-NKNBZPHVSA-F

2.1.4 Canonical SMILES

C(CN(CP(=O)([O-])[O-])CP(=O)([O-])[O-])N(CP(=O)([O-])[O-])CP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Sm+3]

2.1.5 Isomeric SMILES

C(CN(CP(=O)([O-])[O-])CP(=O)([O-])[O-])N(CP(=O)([O-])[O-])CP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[153Sm+3]

2.2 Other Identifiers

2.2.1 UNII

7389YR3OOV

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 153sm-edtmp

2. Quadramet

3. Samarate(5-)-153sm, (((1,2-ethanediylbis((nitrilo-kappa-n)bis(methylene)))tetrakis(phosphonato-kappa-o))(8-))-, Pentahydrogen, (oc-6-21)

4. Samarium (153sm) Lexidronam

5. Samarium Ethylenediaminetetramethylenephosphonate

6. Samarium Sm-153 Lexidronam

7. Samarium-153 Lexidronam

8. Samarium-153-edtmp

9. Sm-edtmp

2.3.2 Depositor-Supplied Synonyms

1. Quadramet

2. Cyt-424

3. 160369-78-8

4. Samarium Sm 153 Lexidronam Pentasodium

5. Quadramet (tn)

6. Samarium Sm 153 Lexidronam Pentasodium [usan]

7. Sm-153 Edtmp Pentasodium

8. 7389yr3oov

9. Samarium (153sm) Lexidronam Sodium (jan)

10. Samarium Sm 153 Lexidronam Pentasodium (usan)

11. Samarium Sm153 Lexidronam Pentasodium

12. Samarium (153sm) Lexidronam Sodium [jan]

13. Samarium Sm 153 Lexidronam Pentasodium Salt [mi]

14. Samarium (153sm) Lexidronam Pentasodium [ema Epar]

15. Samarium Sm-153 Lexidronam Pentasodium [orange Book]

16. Samarium (153sm) Lexidronam Sodium

17. Db09509

18. Samarium (153sm) Lexidronam Pentasodium

19. Samarium (153 Sm) Lexidronam Pentasodium

20. Samarium Sm 153 Lexidronam Pentasodium Salt

21. D05795

22. Q3470652

23. Samarium (153 Sm) Lexidronam Pentasodium [who-dd]

24. Pentasodium;samarium-153(3+);n,n,n',n'-tetrakis(phosphonatomethyl)ethane-1,2-diamine

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₂N₂Na₅O₁₂P₄Sm
Molecular Weight	695.93 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	7
Exact Mass	695.80502 g/mol
Monoisotopic Mass	695.80502 g/mol
Topological Polar Surface Area	259 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	440
Isotope Atom Count	1
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	7

4 Drug and Medication Information

4.1 Drug Indication

Quadramet is indicated for the relief of bone pain in patients with multiple painful osteoblastic skeletal metastases which take up technetium [99mTc]-labelled biphosphonates on bone scan.

The presence of osteoblastic metastases which take up technetium [99mTc]-labelled biphosphonates should be confirmed prior to therapy.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

5.2.2 FDA UNII

7389YR3OOV

5.2.3 Pharmacological Classes

Mechanisms of Action [MoA] - Radiopharmaceutical Activity

5.3 ATC Code

V10BX02