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Protriptyline Hydrochloride

Protriptyline Hydrochloride

Synopsis, Chemistry

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Also known as: 1225-55-4, Protriptyline hcl, Concordin, Maximed, Protriptyline (hydrochloride), Triptyl

Molecular Formula

C₁₉H₂₂ClN

Molecular Weight

299.8 g/mol

InChI Key

OGQDIIKRQRZXJH-UHFFFAOYSA-N

FDA UNII

44665V00O8

Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

1 2D Structure

Protriptyline Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride

2.1.2 InChI

InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

2.1.3 InChI Key

OGQDIIKRQRZXJH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl

2.2 Other Identifiers

2.2.1 UNII

44665V00O8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrochloride, Protriptyline

2. Protriptyline

3. Vivactil

2.3.2 Depositor-Supplied Synonyms

1. 1225-55-4

2. Protriptyline Hcl

3. Concordin

4. Maximed

5. Protriptyline (hydrochloride)

6. Triptyl

7. Triptil Hydrochloride

8. Normethyl Ex4442

9. Mk-240

10. Nsc-169912

11. Mls000069697

12. Triptil

13. Vivactyl

14. 5h-dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-, Hydrochloride (1:1)

15. N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride

16. Smr000058503

17. 44665v00o8

18. Dsstox_cid_26951

19. Dsstox_rid_82027

20. Dsstox_gsid_46951

21. N-methyl-5h-dibenzo(a,d)cycloheptene-5-propylamine Hydrochloride

22. Chebi:8598

23. Triptil (van)

24. 5h-dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, Hydrochloride

25. Nsc169912

26. Sr-01000000208

27. Ncgc00015851-02

28. Cas-1225-55-4

29. N-methyl-5h-dibenzo[a,d]cycloheptene-5-propylamine Hydrochloride

30. 3-(11h-dibenzo[2,1-b:1',2'-e][7]annulen-11-yl)-n-methylpropan-1-amine;hydrochloride

31. Mk-240 (van)

32. Unii-44665v00o8

33. Protriptyline Hydrochloride [usan]

34. Vivactil (tn)

35. Einecs 214-956-3

36. Nsc 169912

37. Protriptyline Hydrochloride [usan:usp]

38. Opera_id_812

39. Mls001074210

40. Mls002222305

41. Schembl119341

42. Chembl1200332

43. Dtxsid8046951

44. Protriptyline Hydrochloride (usp)

45. Regid_for_cid_6603149

46. Hms1570j22

47. Pharmakon1600-01505984

48. 5-(3-methylaminopropyl)-5h-dibenzo(a,d)cycloheptene Hydrochloride

49. Hy-b0949

50. Tox21_110244

51. Tox21_500974

52. Nsc759297

53. S9510

54. Akos024374984

55. Tox21_110244_1

56. Ccg-213590

57. Lp00974

58. Nsc-759297

59. Protriptyline Hydrochloride [mi]

60. Wln: L C676 Bhj B3m1 &gh

61. 5h-dibenzo[a, N-methyl-, Hydrochloride

62. Ncgc00015851-10

63. Ncgc00094274-01

64. Ncgc00094274-02

65. Ncgc00261659-01

66. Ls-14717

67. Protriptyline Hydrochloride [mart.]

68. Protriptyline Hydrochloride [vandf]

69. Protriptyline Hydrochloride [usp-rs]

70. Protriptyline Hydrochloride [who-dd]

71. Eu-0100974

72. D00484

73. P 8813

74. Protriptyline Hydrochloride [orange Book]

75. 225p554

76. Protriptyline Hydrochloride [usp Monograph]

77. J-004824

78. Protriptyline Hydrochloride, >=99% (tlc), Powder

79. Sr-01000000208-2

80. Sr-01000000208-7

81. 4,4-bis(2-sulfonatostyryl)biphenyldisodiumsalt

82. Q27108105

83. 5-[3-(methylamino)propyl]-5h-dibenzo[a,d]cycloheptene Hydrochloride

84. 5h-dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, Hydrochloride

85. N-methyl-5h-dibenzo[a,d]cycloheptene-5-propanamine Hydrochloride

86. Protriptyline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

87. Protriptyline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

88. N-methyl-3-(2-tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride

89. Protriptyline Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2006-05-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₂ClN
Molecular Weight	299.8 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	4
Exact Mass	299.1440774 g/mol
Monoisotopic Mass	299.1440774 g/mol
Topological Polar Surface Area	12 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	296
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Protriptyline hydrochloride
PubMed Health	Protriptyline Hydrochloride (By mouth)
Drug Classes	Antidepressant
Drug Label	Protriptyline hydrochloride, USP is N-methyl-5H dibenzo[a,d]-cycloheptene-5-propanamine hydrochloride. Its structural formula is: C19H21NHCl M.W. 299.84Protriptyline hydrochloride, USP, a dibenzocycloheptene derivative, is a white to yello...
Active Ingredient	Protriptyline hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Epic Pharma; Roxane; Sigmapharm Labs

2 of 2
Drug Name	Protriptyline hydrochloride
PubMed Health	Protriptyline Hydrochloride (By mouth)
Drug Classes	Antidepressant
Drug Label	Protriptyline hydrochloride, USP is N-methyl-5H dibenzo[a,d]-cycloheptene-5-propanamine hydrochloride. Its structural formula is: C19H21NHCl M.W. 299.84Protriptyline hydrochloride, USP, a dibenzocycloheptene derivative, is a white to yello...
Active Ingredient	Protriptyline hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Epic Pharma; Roxane; Sigmapharm Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Adrenergic Uptake Inhibitors

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Tricyclic Antidepressant [EPC]