API SUPPLIERS

API Suppliers

0

US DMFs Filed

0

CEP/COS Certifications

0

JDMFs Filed

0

Other Certificates

0

Other Suppliers

0

API REF. PRICE (USD / KG)

0

API Market Place

0

INTERMEDIATES

0

DOSSIERS // FDF

USA (Orange Book)

1

Europe

0

Canada

0

Australia

0

South Africa

0

Uploaded Dossiers

0

GLOBAL SALES (USD Million)

U.S. Medicaid

0

Annual Reports

0

FDF Market Place

0

EXCIPIENTS

0

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

0

USFDA Exclusivities

0

DIGITAL CONTENT

Blog #PharmaFlow

0

News

0

REF STANDARD

EDQM

0

USP

0

JP

0

Other Listed Suppliers

0

SERVICES

0

Also known as: Largon, Propiomazine hcl, 1240-15-9, Chebi:8492, 70bo17yr03, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-1-propanone monohydrochloride

Molecular Formula

C₂₀H₂₅ClN₂OS

Molecular Weight

376.9 g/mol

InChI Key

UGVNGSMLNPWNNA-UHFFFAOYSA-N

FDA UNII

70BO17YR03

Propiomazine Hydrochloride is the hydrochloride salt form of propiomazine, a phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine H1 receptors; Its antipsychotic effect is attributed to antagonistic activities at dopamine and 5-HT2 receptors.

1 2D Structure

Propiomazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C20H24N2OS.ClH/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;/h6-12,14H,5,13H2,1-4H3;1H

2.1.3 InChI Key

UGVNGSMLNPWNNA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

70BO17YR03

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Largon

2. Propiomazine

2.3.2 Depositor-Supplied Synonyms

1. Largon

2. Propiomazine Hcl

3. 1240-15-9

4. Chebi:8492

5. 70bo17yr03

6. 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-1-propanone Monohydrochloride

7. 1-propanone, 1-(10-(2-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-, Monohydrochloride

8. 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride

9. Unii-70bo17yr03

10. Propiomazine Hydrochloride [usp]

11. Propiomazinhydrochlorid

12. Surecn720224

13. Schembl141677

14. Chembl1201068

15. Dtxsid80872383

16. Propiomazine Hydrochloride [mi]

17. (+/-)-propiomazine Hydrochloride

18. Propiomazine Hydrochloride [mart.]

19. Propiomazine Hydrochloride [vandf]

20. Propiomazine Hydrochloride [who-dd]

21. Propiomazine Hydrochloride, (+/-)-

22. C07384

23. Propiomazine Hydrochloride [orange Book]

24. Q27108092

25. 1-propanone, 1-(10-(2-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₅ClN₂OS
Molecular Weight	376.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	376.1376123 g/mol
Monoisotopic Mass	376.1376123 g/mol
Topological Polar Surface Area	48.8 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	441
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2