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Previcox
Also known as: 189954-96-9, Equioxx, Previcox, Librens, Ml 1785713, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one
Molecular Formula
C17H20O5S
Molecular Weight
336.4  g/mol
InChI Key
FULAPETWGIGNMT-UHFFFAOYSA-N
FDA UNII
Y6V2W4S4WT

Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.
1 2D Structure

Previcox

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
2.1.2 InChI
InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
2.1.3 InChI Key
FULAPETWGIGNMT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C
2.2 Other Identifiers
2.2.1 UNII
Y6V2W4S4WT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

2. Equioxx

3. Ml 1,785,713

4. Ml 1785713

5. Ml-1,785,713

6. Ml-1785713

7. Ml1,785,713

8. Ml1785713

2.3.2 Depositor-Supplied Synonyms

1. 189954-96-9

2. Equioxx

3. Previcox

4. Librens

5. Ml 1785713

6. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

7. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one

8. Ml-1,785,713

9. Nsc-758895

10. Y6v2w4s4wt

11. Chembl69998

12. Chebi:76136

13. Firocoxib (ema Epar: Veterinary)

14. Equixx

15. Ml-1785713

16. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

17. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-

18. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-

19. 3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one

20. Firocoxib [usan:inn]

21. Unii-y6v2w4s4wt

22. Firocoxibum

23. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5h)-furanone

24. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5h)-one

25. Firocoxib [inn]

26. Firocoxib [mi]

27. Firocoxib (usan/inn)

28. Firocoxib [usan]

29. Firocoxib [mart.]

30. Equioxx (tn) [veterinary]

31. Firocoxib [green Book]

32. Amy378

33. Schembl1383179

34. Dtxsid40870188

35. Hms3264g15

36. Pharmakon1600-01504526

37. Bcp07253

38. Zinc3623447

39. Bdbm50080082

40. Nsc758895

41. Ccg-213396

42. Cs-3419

43. Db09217

44. Nsc 758895

45. Ncgc00389572-01

46. Ncgc00389572-02

47. Ac-33540

48. As-73802

49. Hy-14670

50. Sbi-0206717.p001

51. Ft-0668544

52. Firocoxib, Vetranal(tm), Analytical Standard

53. C18363

54. C73637

55. D03712

56. Ab01563063_01

57. 954f969

58. A918990

59. Sr-01000872758

60. J-012265

61. Q2034390

62. Sr-01000872758-1

63. 3-(cyclopropylmethoxy)-4-(4-methylsulfonyl)phenyl)-5,5-dimethylfuranone

64. 3-(cyclopropylmethoxy)-4-[4-(methanesulfonyl)phenyl]-5,5-dimethylfuran-2(5h)-one

65. 3-cyclopropylmethoxy-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5h-furan-2-one

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 336.4 g/mol
Molecular Formula C17H20O5S
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass336.10314491 g/mol
Monoisotopic Mass336.10314491 g/mol
Topological Polar Surface Area78 Ų
Heavy Atom Count23
Formal Charge0
Complexity614
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used for the treatment of pain inflammation and fever in horses and dogs.


* Tablets:

For the relief of pain and inflammation associated with osteoarthritis in dogs.

For the relief of postoperative pain and inflammation associated with soft-tissue, orthopaedic and dental surgery in dogs.

* Oral paste:

Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.


Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.


5 Pharmacology and Biochemistry
5.1 ATC Code

QM01AH90


QM01AH90


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