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    Chemistry

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    Also known as: 58-33-3, Promethazine hcl, Phenergan, N,n-dimethyl-1-(10h-phenothiazin-10-yl)propan-2-amine hydrochloride, Fenergan, Remsed
    Molecular Formula
    C17H21ClN2S
    Molecular Weight
    320.9  g/mol
    InChI Key
    XXPDBLUZJRXNNZ-UHFFFAOYSA-N
    FDA UNII
    R61ZEH7I1I
    Promethazine Hydrochloride
    A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
    1 2D Structure

    Promethazine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
    2.1.3 InChI Key
    XXPDBLUZJRXNNZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    R61ZEH7I1I
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Atosil

    2. Diphergan

    3. Diprazin

    4. Hydrochloride, Promethazine

    5. Isopromethazine

    6. Phenargan

    7. Phenergan

    8. Phensedyl

    9. Pipolfen

    10. Pipolphen

    11. Proazamine

    12. Promet

    13. Prometazin

    14. Promethazine

    15. Prothazin

    16. Pyrethia

    17. Remsed

    18. Rumergan

    2.3.2 Depositor-Supplied Synonyms

    1. 58-33-3

    2. Promethazine Hcl

    3. Phenergan

    4. N,n-dimethyl-1-(10h-phenothiazin-10-yl)propan-2-amine Hydrochloride

    5. Fenergan

    6. Remsed

    7. Promethazine (hydrochloride)

    8. Diprasine

    9. Diprazin

    10. Fellozine

    11. Pipolfen

    12. Pipolphen

    13. Ganphen

    14. Plletia

    15. Prometh Fortis

    16. Prometh Plain

    17. Promethazine.hcl

    18. Mymethazine Fortis

    19. Anergan 25

    20. Promethacon

    21. Promethegan

    22. Romergan

    23. Promethazine Chloride

    24. Promethiazin

    25. Zipan-25

    26. V Gan

    27. Lergigan

    28. Pyrethia

    29. Zipan-50

    30. Promethazine Monohydrochloride

    31. Hl 8700

    32. N-(2-dimethylaminopropyl-1)phenothiazine Hydrochloride

    33. 10-[2-(dimethylamino)propyl]phenothiazine Hydrochloride

    34. N,n-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride

    35. N-(2'-dimethylamino-2'-methyl)ethylphenothiazine Hydrochloride

    36. R61zeh7i1i

    37. 10-(3-dimethylaminoisopropyl)phenothiazine Hydrochloride

    38. 3277 R.p.

    39. Mls000069398

    40. 10-(2-dimethylamino-1-propyl)phenothiazine Hydrochloride

    41. Chebi:8462

    42. Farganesse

    43. Avomine

    44. Nsc-231688

    45. 58-33-3 (hcl)

    46. Allerfen

    47. Duplamin

    48. Frinova

    49. Goodnight

    50. Hibechin

    51. Histantil

    52. Kinetosin

    53. Phenadoz

    54. Phencen

    55. Primine

    56. Promantine

    57. Promine

    58. Proneurin

    59. Smr000058379

    60. Soporil

    61. Bonnox

    62. Closin

    63. Dorme

    64. Prome

    65. (+-)-10-(2-(dimethylamino)propyl)phenothiazine Monohydrochloride

    66. Eusedon Mono

    67. Phenergan Fortis

    68. Dsstox_cid_1192

    69. Pms Promethazine

    70. Promethazine Plain

    71. Dsstox_rid_76002

    72. Dsstox_gsid_21192

    73. 1435933-86-0

    74. Anergan 50

    75. Promethazine Hydrochloride 100 Microg/ml In Acetonitrile

    76. Phenergan Plain

    77. Promethiazin [german]

    78. Ccris 5873

    79. Phenergan Hydrochloride

    80. Promethazine Hydrochloride [jan]

    81. Promethazinehydrochloride

    82. Einecs 200-375-2

    83. Mfcd00012652

    84. Unii-r61zeh7i1i

    85. Nsc 231688

    86. Genphen

    87. Sr-01000002993

    88. Phanergan D

    89. Phenergan (tn)

    90. Promethegan (tn)

    91. 10-(2-dimethylaminopropyl)phenothiazine Hydrochloride

    92. Component Of Mepergan

    93. Promethazine Hydrochloride [usp:jan]

    94. Promethazine-d3 Hcl

    95. 10-(2-(dimethylamino)propyl)phenothiazine Monohydrochloride

    96. Cpd000058379

    97. Phenothiazine, 10-(2-(dimethylamino)-propyl)-, Hydrochloride

    98. Pronase [jan]

    99. Promethazine Hydrochlorine

    100. Cas-58-33-3

    101. Opera_id_1745

    102. 10h-phenothiazine-10-ethanamine, N,n,alpha-trimethyl-, Monohydrochloride

    103. Diprazinum [who-ip]

    104. Schembl41904

    105. Mls001074184

    106. Mls002548850

    107. Spectrum1500510

    108. Chembl1200750

    109. Dtxsid3021192

    110. Promethazine Hydrochloride Solution

    111. Hms1570b18

    112. Hms1920l16

    113. Pharmakon1600-01500510

    114. Hy-b0781

    115. N,n-dimethyl-1-phenothiazin-10-yl-propan-2-amine Hydrochloride

    116. Phenothiazine, 10-(2-(dimethylamino)propyl)-, Monohydrochloride

    117. Promethazine For Peak Identification

    118. Tox21_202264

    119. Tox21_302878

    120. Tox21_500899

    121. Nsc231688

    122. Nsc757301

    123. S4293

    124. 10h-phenothiazine-10-ethanamine, N,n,.alpha.-trimethyl-, Monohydrochloride

    125. Akos016339657

    126. Ccg-207895

    127. Cs-3543

    128. Ks-1385

    129. Lp00899

    130. Nc00471

    131. Nsc-757301

    132. Promethazine Hydrochloride (jp17/usp)

    133. Promethazine Hydrochloride [mi]

    134. Rp-3389

    135. 10h-phenothiazine-10-ethanamine, N,n,alpha-trimethyl-, Monohydrochloride, (+-)-

    136. Ncgc00089735-04

    137. Ncgc00094215-01

    138. Ncgc00094215-02

    139. Ncgc00094215-03

    140. Ncgc00094215-04

    141. Ncgc00094215-05

    142. Ncgc00256588-01

    143. Ncgc00259813-01

    144. Ncgc00261584-01

    145. Ac-12482

    146. Bp166198

    147. Promethazine Hydrochloride [mart.]

    148. Promethazine Hydrochloride [vandf]

    149. Promethazine Hydrochloride [usp-rs]

    150. Promethazine Hydrochloride [who-dd]

    151. Promethazine Hydrochloride [who-ip]

    152. Db-053186

    153. Eu-0100899

    154. P2029

    155. Sw197234-3

    156. D00480

    157. D92182

    158. P 4651

    159. Promethazine Hydrochloride [orange Book]

    160. Promethazine Hydrochloride [ep Monograph]

    161. Promethazine Hydrochloride [usp Impurity]

    162. Wln: T C666 Bn Isj B1y1&n1&1 &gh

    163. A831833

    164. Promethazine Hydrochloride [usp Monograph]

    165. Promethazini Hydrochloridum [who-ip Latin]

    166. Mepergan Component Promethazine Hydrochloride

    167. Sr-01000002993-2

    168. Sr-01000002993-7

    169. W-105399

    170. Promethazine Hydrochloride Component Of Mepergan

    171. Q27108086

    172. F0138-3355

    173. Phenergan Vc Component Promethazine Hydrochloride

    174. Pherazine Dm Component Promethazine Hydrochloride

    175. Pherazine Vc Component Promethazine Hydrochloride

    176. Z1259273234

    177. ((c)i)-promethazine-d4 Hcl (phenothiazine-1,3,7,9-d4)

    178. Promethazine Dm Component Promethazine Hydrochloride

    179. Promethazine Hydrochloride Component Of Phenergan Vc

    180. Promethazine Hydrochloride Component Of Pherazine Dm

    181. Promethazine Hydrochloride Component Of Pherazine Vc

    182. Promethazine Vc Component Promethazine Hydrochloride

    183. N,n-dimethyl-1-(10-phenothiazinyl)-2-propanamine Hydrochloride

    184. N-(2'-dimethylamino-2'-methylaethyl)-phenothiazin Hydrochlorid

    185. N-(2'-dimethylamino-2-methylethyl)phenothiazine Hydrochloride

    186. Promethazine Hydrochloride Component Of Promethazine Dm

    187. Promethazine Hydrochloride Component Of Promethazine Vc

    188. Promethazine Hydrochloride, Vetranal(tm), Analytical Standard

    189. N,n-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydron;chloride

    190. (+/-)-10-(2-(dimethylamino)propyl)phenothiazine Monohydrochloride

    191. 10h-phenothiazine-10-ethanamine,n,.alpha.-trimethyl-, Monohydrochloride

    192. Dimethyl[1-(10h-phenothiazin-10-yl)propan-2-yl]amine Hydrochloride

    193. N,n-dimethyl-1-(10h-phenothiazin-10-yl)-2-propanamine Hydrochloride

    194. Promethazine Hydrochloride 1.0 Mg/ml In Dimethyl Sulfoxide (as Free Base)

    195. Promethazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    196. Promethazine Hydrochloride, Vial Of 25 Mg, Certified Reference Material

    197. 10h-phenothiazine-10-ethanamine, N,n,.alpha.-trimethyl-, Monohydrochloride, (+/-)-

    198. 10h-phenothiazine-10-ethanamine, N,n,alpha-trimethyl-, Hydrochloride (1:1)

    199. Promethazine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    200. Promethazine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    201. Promethazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 320.9 g/mol
    Molecular Formula C17H21ClN2S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass320.1113975 g/mol
    Monoisotopic Mass320.1113975 g/mol
    Topological Polar Surface Area31.8 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity298
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NamePromethazine hydrochloride
    Drug LabelDESCRIPTIONPromethazine hydrochloride is a racemic compound.Promethazine hydrochloride, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N,-trimethyl-, monohydrochloride, ()-with the following structural...
    Active IngredientPromethazine hydrochloride
    Dosage FormTablet; Syrup; Suppository; Injectable
    RouteRectal; Injection; Oral
    Strength25mg; 50mg/ml; 25mg/ml; 6.25mg/5ml; 50mg; 12.5mg
    Market StatusPrescription
    CompanyVintage Pharms; Amneal Pharms; Wockhardt; Hospira; Sun Pharm Inds; Teva Pharms Usa; Taro; Sandoz; Watson Labs; Amneal Pharms Ny; Hi Tech Pharma; Caraco; Hikma Maple; Kvk Tech; X-gen Pharms; Vintage; Emcure Pharms Usa; Perrigo New York; Luitpold; Zydus Pha

    2 of 4  
    Drug NamePromethazine plain
    Active IngredientPromethazine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength6.25mg/5ml
    Market StatusPrescription
    CompanyWockhardt

    3 of 4  
    Drug NamePromethazine hydrochloride
    Drug LabelDESCRIPTIONPromethazine hydrochloride is a racemic compound.Promethazine hydrochloride, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N,-trimethyl-, monohydrochloride, ()-with the following structural...
    Active IngredientPromethazine hydrochloride
    Dosage FormTablet; Syrup; Suppository; Injectable
    RouteRectal; Injection; Oral
    Strength25mg; 50mg/ml; 25mg/ml; 6.25mg/5ml; 50mg; 12.5mg
    Market StatusPrescription
    CompanyVintage Pharms; Amneal Pharms; Wockhardt; Hospira; Sun Pharm Inds; Teva Pharms Usa; Taro; Sandoz; Watson Labs; Amneal Pharms Ny; Hi Tech Pharma; Caraco; Hikma Maple; Kvk Tech; X-gen Pharms; Vintage; Emcure Pharms Usa; Perrigo New York; Luitpold; Zydus Pha

    4 of 4  
    Drug NamePromethazine plain
    Active IngredientPromethazine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength6.25mg/5ml
    Market StatusPrescription
    CompanyWockhardt

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phenothiazines [CS]; Phenothiazine [EPC]

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Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698690600,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"183","totalValueFC":"78583.1","currency":"EURO","unitRateINR":"16351.1","date":"31-Oct-2023","totalValueINR":"6540420","totalValueInUsd":"78583.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8554161","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 KERESZTURI, HungarySDNF Hungary","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702060200,"product":"PROMETHAZINE HYDROCHLORIDE","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"MEDREICH LIMITED","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"227","totalValueFC":"18683","currency":"EURO","unitRateINR":"20736.5","date":"09-Dec-2023","totalValueINR":"1555233.75","totalValueInUsd":"18683","indian_port":"Bangalore Air","hs_no":"29359090","bill_no":"9151659","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1160 BUDAPEST KERESZTURI UT 30-38SDNFSDNF HUNGARY","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API 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NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"N\/A","customer":"AMNEAL PHARMACEUTICALS PVT LTD","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"300","unit":"GMS","unitRateFc":"0","totalValueFC":"5.6","currency":"USD","unitRateINR":"1.5","date":"22-Dec-2023","totalValueINR":"462","totalValueInUsd":"5.6","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29343000","bill_no":"1005162","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 HUNGARY Hungary Hungary","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706639400,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"11.72","actualQuantity":"11.72","unit":"KGS","unitRateFc":"183","totalValueFC":"2381.9","currency":"EURO","unitRateINR":"16890.9","date":"31-Jan-2024","totalValueINR":"197961.35","totalValueInUsd":"2381.9","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9911675","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 KERESZTURI, , HungarySDNF Hungary","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706639400,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"188.28","actualQuantity":"188.28","unit":"KGS","unitRateFc":"183","totalValueFC":"38264.4","currency":"EURO","unitRateINR":"16890.9","date":"31-Jan-2024","totalValueINR":"3180218.65","totalValueInUsd":"38264.4","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9911675","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 KERESZTURI, , HungarySDNF Hungary","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707417000,"product":"PROMETHAZINE HYDROCHLORIDE","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"MEDREICH LIMITED","customerCountry":"INDIA","quantity":"35.00","actualQuantity":"35","unit":"KGS","unitRateFc":"227","totalValueFC":"8756.6","currency":"EURO","unitRateINR":"20759.2","date":"09-Feb-2024","totalValueINR":"726570.25","totalValueInUsd":"8756.6","indian_port":"Bangalore Air","hs_no":"29359090","bill_no":"2067367","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38SDNFSDNF HUNGARY","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713897000,"product":"PROMETHAZINE HCL U.S.P.","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUKA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"183","totalValueFC":"49718","currency":"EURO","unitRateINR":"16607.3","date":"24-Apr-2024","totalValueINR":"4151812.5","totalValueInUsd":"49718","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3174888","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUKA","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 KERESZTURI, HungarySDNF Hungary","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714501800,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ZYDUS LIFESCIENCES 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A30,A.I.E"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721413800,"product":"PROMETHAZINE HYDROCHLORIDE","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"MEDREICH LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"227","totalValueFC":"12586.8","currency":"EURO","unitRateINR":"21042.9","date":"20-Jul-2024","totalValueINR":"1052145","totalValueInUsd":"12586.8","indian_port":"Bangalore Air","hs_no":"29359090","bill_no":"4623767","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1160 BUDAPEST KERESZTURI UT 30-38SDNFSDNF HUNGARY","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721586600,"product":"PROMETHAZINE HYDROCHLORIDE","address":"206, DEVAVRATA,","city":"NAVI MUMBAI, MAHARASHTRA.","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"STRIDES PHARMA SCIENCE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"355","totalValueFC":"19684.2","currency":"EURO","unitRateINR":"32908.5","date":"22-Jul-2024","totalValueINR":"1645425","totalValueInUsd":"19684.2","indian_port":"Bangalore Air","hs_no":"29343000","bill_no":"4647621","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTRIT 30-38.SDNF HUNGARY","customerAddress":"206, DEVAVRATA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722450600,"product":"PROMETHAZINE HYDROCHLORIDE","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"HETERO LABS LIMITED","customerCountry":"INDIA","quantity":"85.00","actualQuantity":"85","unit":"KGS","unitRateFc":"355","totalValueFC":"33348.5","currency":"EURO","unitRateINR":"32908.5","date":"01-Aug-2024","totalValueINR":"2797222.5","totalValueInUsd":"33348.5","indian_port":"Madras Air","hs_no":"29349990","bill_no":"4821815","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"H-1106 BUDAPESTKERESZTURIUT 30-38 HUNGARY","customerAddress":"HETERO CORPORATE, NO. 7-2-A2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724265000,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"SHANKAR TOWERS PLOT NO. A30,A.I.E","city":"HYDERABAD,TELANGANA","supplier":"SANOFI WINTHROP INDUSTRIE","supplierCountry":"FRANCE","foreign_port":"MARSEILLE","customer":"ANTHEA PHARMA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"450","totalValueFC":"91042.4","currency":"USD","unitRateINR":"38182.5","date":"22-Aug-2024","totalValueINR":"7636500","totalValueInUsd":"91042.4","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"5186489","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"MARSEILLE","supplierAddress":"45 CHEMIN DE METELINE04200 SISTERONSDNF FR","customerAddress":"SHANKAR TOWERS PLOT NO. A30,A.I.E"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726425000,"product":"PROMETHAZINE HYDROCHLORIDE -E-159953271026397681\/E-159953271026397667","address":"7\/1,CORPORATE PARK,SION-TROMBAY","city":"MUMBAI","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"FLAMINGO PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"377","totalValueFC":"21312.8","currency":"EURO","unitRateINR":"35720.8","date":"16-Sep-2024","totalValueINR":"1786037.5","totalValueInUsd":"21312.8","indian_port":"Bombay Air","hs_no":"29349990","bill_no":"5631861","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38.H UNGRY SDNF HUNGARY","customerAddress":"7\/1,CORPORATE PARK,SION-TROMBAY"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"PROMETHAZINE HCL (RAW MATERIAL)","address":"PLOT NO.A-177,ROAD NO.16-Z,WAGLE","city":"THANE, MAHARASHTRA","supplier":"PT VITABIOTICS HEA1THCARE","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"MEYER ORGANICS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.97","actualQuantity":"0.972","unit":"KGS","unitRateFc":"75.6","totalValueFC":"75.3","currency":"USD","unitRateINR":"6491.8","date":"21-Sep-2024","totalValueINR":"6309.99","totalValueInUsd":"75.3","indian_port":"JNPT","hs_no":"29420090","bill_no":"5729603","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JAKARTA","supplierAddress":"JL RAYA CARINGIN NO. 363, KEL. KER TAJAYA, KEC. PADALARANG KAB. BANDUN G BARAT, PROV. JAWA BARAT, INDONESI Indonesia","customerAddress":"PLOT NO.A-177,ROAD NO.16-Z,WAGLE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727116200,"product":"PROMETHAZINE HYDROCHLORIDE","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"WATSON PHARMA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"226","totalValueFC":"153235.5","currency":"EURO","unitRateINR":"21402.2","date":"24-Sep-2024","totalValueINR":"12841320","totalValueInUsd":"153235.5","indian_port":"Bombay Air","hs_no":"29343000","bill_no":"5774042","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 . , , Hungary SDNF Hungary","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732732200,"product":"PROMETHAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"183","totalValueFC":"78761.7","currency":"EURO","unitRateINR":"16616.4","date":"28-Nov-2024","totalValueINR":"6646560","totalValueInUsd":"78761.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"6928981","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 K ERESZTURI, Hungary SDNF Hungary","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745778600,"product":"PROMETHAZINE HYDROCHLORIDE USP PROMETHAZINE HYDROCHLORIDE USP","address":"7-2-A2, GROUND FLOOR, HETERO,CORPO","city":"SANATHNAGAR,TELANGANA","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"ANNORA PHARMA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"26.00","actualQuantity":"26","unit":"KGS","unitRateFc":"407","totalValueFC":"10680.1","currency":"EURO","unitRateINR":"35162.8","date":"28-Apr-2025","totalValueINR":"914231.5","totalValueInUsd":"10680.1","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"9759480","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"1106 BUDAPEST KERESZTURI UT 30-38 B udapest, , Hungary SDNF Hungary","customerAddress":"7-2-A2, GROUND FLOOR, HETERO,CORPO"}]
    22-Jan-2022
    28-Apr-2025
    KGS
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    API Imports and Exports

    Importing Country Total Quantity
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    (USD/KGS)    		 Number of Transactions

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    South Africa

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    01

    Pharmacare Limited, Woodmead

    South Africa
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    Digital Content Digital Content

    Regulatory Info : Generic

    Registration Country : South Africa

    promethazine HCl

    Brand Name : Histodor

    Dosage Form : TAB

    Dosage Strength : 5mg

    Packaging : 1000X1mg

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    02

    Pharmacare Limited, Woodmead

    South Africa
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    Digital Content Digital Content

    Regulatory Info : Generic

    Registration Country : South Africa

    Promethazine HCl

    Brand Name : Stilpane

    Dosage Form : SYR

    Dosage Strength : 6.5mg/5ml

    Packaging : 100X1mg/5ml

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    03

    Adcock Ingram Limited

    South Africa
    Pharma Summit
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    Adcock Ingram Limited

    South Africa
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    Regulatory Info : Generic

    Registration Country : South Africa

    Promethazine Hydrochloride

    Brand Name : Lentogesic Syrup

    Dosage Form : SYR

    Dosage Strength : 120mg/5ml

    Packaging : 100X1mg/5ml

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    Promethazine Hydrochloride

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    Promethazine Hydrochloride

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    Promethazine Hcl

    Brand Name : Promethazine Hcl Fresenius 50Mg/2Ml

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    Promethazine HCl

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 25MG/ML

    USFDA APPLICATION NUMBER - 83312

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    DOSAGE - INJECTABLE;INJECTION - 50MG/ML

    USFDA APPLICATION NUMBER - 83312

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    DOSAGE - SYRUP;ORAL - 6.25MG/5ML

    USFDA APPLICATION NUMBER - 87953

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    DOSAGE - SYRUP;ORAL - 5MG/5ML;6.25MG/5ML

    USFDA APPLICATION NUMBER - 88761

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    DOSAGE - SYRUP;ORAL - 10MG/5ML;6.25MG/5ML

    USFDA APPLICATION NUMBER - 88763

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    ABOUT THIS PAGE

    Looking for 58-33-3 / Promethazine Hydrochloride API manufacturers, exporters & distributors?

    Promethazine Hydrochloride manufacturers, exporters & distributors 1

    94

    PharmaCompass offers a list of Promethazine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Promethazine Hydrochloride manufacturer or Promethazine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Promethazine Hydrochloride manufacturer or Promethazine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Promethazine Hydrochloride API Price utilized in the formulation of products. Promethazine Hydrochloride API Price is not always fixed or binding as the Promethazine Hydrochloride Price is obtained through a variety of data sources. The Promethazine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Promethazine Hydrochloride

    Synonyms

    58-33-3, Promethazine hcl, Phenergan, N,n-dimethyl-1-(10h-phenothiazin-10-yl)propan-2-amine hydrochloride, Fenergan, Remsed

    Cas Number

    58-33-3

    Unique Ingredient Identifier (UNII)

    R61ZEH7I1I

    About Promethazine Hydrochloride

    A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

    Phenergan Manufacturers

    A Phenergan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Phenergan, including repackagers and relabelers. The FDA regulates Phenergan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Phenergan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Phenergan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Phenergan Suppliers

    A Phenergan supplier is an individual or a company that provides Phenergan active pharmaceutical ingredient (API) or Phenergan finished formulations upon request. The Phenergan suppliers may include Phenergan API manufacturers, exporters, distributors and traders.

    click here to find a list of Phenergan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Phenergan USDMF

    A Phenergan DMF (Drug Master File) is a document detailing the whole manufacturing process of Phenergan active pharmaceutical ingredient (API) in detail. Different forms of Phenergan DMFs exist exist since differing nations have different regulations, such as Phenergan USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Phenergan DMF submitted to regulatory agencies in the US is known as a USDMF. Phenergan USDMF includes data on Phenergan's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Phenergan USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Phenergan suppliers with USDMF on PharmaCompass.

    Phenergan JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Phenergan Drug Master File in Japan (Phenergan JDMF) empowers Phenergan API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Phenergan JDMF during the approval evaluation for pharmaceutical products. At the time of Phenergan JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Phenergan suppliers with JDMF on PharmaCompass.

    Phenergan CEP

    A Phenergan CEP of the European Pharmacopoeia monograph is often referred to as a Phenergan Certificate of Suitability (COS). The purpose of a Phenergan CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Phenergan EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Phenergan to their clients by showing that a Phenergan CEP has been issued for it. The manufacturer submits a Phenergan CEP (COS) as part of the market authorization procedure, and it takes on the role of a Phenergan CEP holder for the record. Additionally, the data presented in the Phenergan CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Phenergan DMF.

    A Phenergan CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Phenergan CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Phenergan suppliers with CEP (COS) on PharmaCompass.

    Phenergan WC

    A Phenergan written confirmation (Phenergan WC) is an official document issued by a regulatory agency to a Phenergan manufacturer, verifying that the manufacturing facility of a Phenergan active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Phenergan APIs or Phenergan finished pharmaceutical products to another nation, regulatory agencies frequently require a Phenergan WC (written confirmation) as part of the regulatory process.

    click here to find a list of Phenergan suppliers with Written Confirmation (WC) on PharmaCompass.

    Phenergan NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Phenergan as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Phenergan API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Phenergan as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Phenergan and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Phenergan NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Phenergan suppliers with NDC on PharmaCompass.

    Phenergan GMP

    Phenergan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Phenergan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Phenergan GMP manufacturer or Phenergan GMP API supplier for your needs.

    Phenergan CoA

    A Phenergan CoA (Certificate of Analysis) is a formal document that attests to Phenergan's compliance with Phenergan specifications and serves as a tool for batch-level quality control.

    Phenergan CoA mostly includes findings from lab analyses of a specific batch. For each Phenergan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Phenergan may be tested according to a variety of international standards, such as European Pharmacopoeia (Phenergan EP), Phenergan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Phenergan USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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