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Phenazepam

Phenazepam

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Also known as: 51753-57-2, Fenazepam, Phenazapam, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Bd 98, C15h10brcln2o

Molecular Formula

C₁₅H₁₀BrClN₂O

Molecular Weight

349.61 g/mol

InChI Key

CGMJQQJSWIRRRL-UHFFFAOYSA-N

FDA UNII

3DSB43090Z

1 2D Structure

Phenazepam

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

2.1.2 InChI

InChI=1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

2.1.3 InChI Key

CGMJQQJSWIRRRL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=C3Cl

2.2 Other Identifiers

2.2.1 UNII

3DSB43090Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 7-bromo-5-(2-chlorophenyl) 1,3-dihydro-2h-1,4-benzodiazepin-2-one

2. 7-bromo-5-(2-chlorphenyl)-1,2-dihydro-3h-1,4-benzodiazepin-2-one

3. Fenazepam

4. Phenazepam, 2-(14)c-labeled Cpd

2.3.2 Depositor-Supplied Synonyms

1. 51753-57-2

2. Fenazepam

3. Phenazapam

4. 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one

5. Bd 98

6. C15h10brcln2o

7. 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

8. 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3h-1,4-benzodiazepin-2-one

9. 3dsb43090z

10. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-chlorophenyl)-

11. 2h-1,4-benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-

12. Brn 0889456

13. Unii-3dsb43090z

14. Phenzitat

15. Phenazepam-d4 Solution

16. Chemdivam_001103

17. 7-bromo-5-(2-chlorophenyl)-2,3-dihydro-1h-1,4-benzodiazepin-2-one

18. Chemdiv1_028228

19. Phenazepam, Beta-polymorph

20. Phenazepam [mart.]

21. Mixcom6_000420

22. N05ba

23. Phenazepam [who-dd]

24. Oprea1_009938

25. Oprea1_527397

26. 5-24-04-00341 (beilstein Handbook Reference)

27. Mls001143339

28. Schembl416137

29. Zinc1919

30. Chembl1709464

31. Hms667d02

32. Dtxsid00199685

33. 5-(2-chlorophenyl)-7-bromo-1,4-benzodiazepin-2-one

34. Bd-98

35. Hms2780h09

36. Phenazepam 0.1 Mg/ml In Methanol

37. Phenazepam 1.0 Mg/ml In Methanol

38. Bcp22944

39. Stk183542

40. Akos000668996

41. Ncgc00390271-01

42. Smr000473174

43. Bcp0726000150

44. 753p572

45. Q421138

46. 7-bromo-5-(2-chlorophenyl)-1h-1,4-benzodiazepin-2(3h)-one

47. 7-bromo-5-(2-chlorophenyl)-1h-benzo[e][1,4]diazepin-2(3h)-one

48. 7-bromo-5-(2'-chloro-phenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one

49. 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one #

50. 7-bromo-5-(2-chlorophenyl)-1,3-dihydrobenzo[e]-1,4-diazepin-2-one 2h-1,4-benzodiazepin-2-one

51. Phenazepam Solution, 1.0 Mg/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-03-28

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₀BrClN₂O
Molecular Weight	349.61 g/mol
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	347.96650 g/mol
Monoisotopic Mass	347.96650 g/mol
Topological Polar Surface Area	41.5 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	415
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

GABA Agents

Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as GABA Agents.)

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)