Pemetrexed

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

21 API Suppliers, 4 USDMF, 7 NDC API, 17 Listed Suppliers

DEVELOPMENTS

79 Drug(s) in Development

79 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

INTERMEDIATES

16 Suppliers

16 Suppliers

DOSSIERs // Finished Dosage Formulations

120 Dossiers, 12 FDA Orange Book, 27 Europe, 10 Canada, 20 Australia, 13 South Africa, 38 Listed Dossiers

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions, 21 Finished Drug Prices

MARKET PLACE

6 APIs, 14 DOSSIERS // FDF, 1 Intermediates

PATENTS

2 US Patents, 8 Health Canada Patents

ANALYTICAL SOLUTION(s)

1 USP Standards, 5 Other Ref. Standards

DIGITAL CONTENT

5 Data Compilations & Company Tracker #PharmaFlow, 112 News

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US DMFs Filed

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JDMFs Filed

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API REF. PRICE (USD / KG)

18,582

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INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

67.00

Annual Reports

2,133.00

FDF Market Place

EXCIPIENTS

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USFDA Orange Book Patents

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DIGITAL CONTENT

Blog #PharmaFlow

News

112

REF STANDARD

EDQM

USP

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SERVICES

Also known as:

Molecular Formula

C₂₀H₂₁N₅O₆

Molecular Weight

427.4 g/mol

InChI Key

WBXPDJSOTKVWSJ-CYBMUJFWSA-N

1 2D Structure

Pemetrexed

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

2.1.2 InChI

InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m1/s1

2.1.3 InChI Key

WBXPDJSOTKVWSJ-CYBMUJFWSA-N

2.1.4 Canonical SMILES

C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@H](CCC(=O)O)C(=O)O

2.2 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₁N₅O₆
Molecular Weight	427.4 g/mol
XLogP3	0.2
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	427.14918341 g/mol
Monoisotopic Mass	427.14918341 g/mol
Topological Polar Surface Area	187 A^2
Heavy Atom Count	31
Formal Charge	0
Complexity	748
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Alimta
PubMed Health	Pemetrexed (Injection)
Drug Classes	Antineoplastic Agent
Drug Label	Pemetrexed disodium heptahydrate has the chemical name L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate. It is a white to almost-white solid with a molecular formula of C...
Active Ingredient	Pemetrexed; Pemetrexed disodium
Dosage Form	Injectable
Route	injection; Iv (infusion)
Strength	eq 500mg base/vial; 500mg; eq 100mg base/vial
Market Status	Prescription
Company	Lilly

2 of 2
Drug Name	Alimta
PubMed Health	Pemetrexed (Injection)
Drug Classes	Antineoplastic Agent
Drug Label	Pemetrexed disodium heptahydrate has the chemical name L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate. It is a white to almost-white solid with a molecular formula of C...
Active Ingredient	Pemetrexed; Pemetrexed disodium
Dosage Form	Injectable
Route	injection; Iv (infusion)
Strength	eq 500mg base/vial; 500mg; eq 100mg base/vial
Market Status	Prescription
Company	Lilly